Changes in Central Corneal Thickness, Intraocular Pressure, and Oxidation/Antioxidation Parameters at High Altitude

Karaküçük, Sarper; Müjdeci̇, M.; Başkol, Gülden; Arda, Hatice; Gümüş, Koray; Öner, Ayşe

doi:10.3357/asem.3357.2012

Cited by 18 publications

(20 citation statements)

References 18 publications

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“…16 Acute hypoxia can cause increase to central corneal thickness with swelling, while corneal swelling diminishes over time. 17 The fact that a tissue using up excessive oxygen such as cornea is quite probable to be consistently hypoxic in OSAS cases, though our study found no significant difference in corneal thickness between the groups. 6 , 18 , 19 However, in a study conducted by Koseoglu et al with 195 participants, corneal thickness decreased in OSAS group compared to the control group.…”

Section: Discussioncontrasting

confidence: 66%

Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Teberik¹,

Eski²,

Balbay³

et al. 2018

Pak J Med Sci

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Objective:To evaluate the intraocular pressure (IOP), central corneal thickness (CCT), and peripapillary retinal nerve fiber layer (RNFL) thickness in Patients with Obstructive Sleep Apnea Syndrome.Methods:In this prospective study, 103 patients with OSAS (study group) and 37 healthy subjects were enrolled. All participants underwent comprehensive ophthalmic examinations. Mean outcome measures were intraocular pressure by Goldmann applanation tonometry, CCT measurement using ultrasound pachymeter and peripapillary RNFL thickness measured by spectral-domain optical coherence tomography.Results:The differences between the mean values of RNFL thickness in all quadrants were similar in both groups and were not statistically significant (p=0.274). The IOP and CCT measurement averages of all patients with OSAS were lower than the control group. However, this difference was not statistically significant. There was no correlation between the apnea-hypopnea index, lowest oxygen saturation (LAST) or Body Mass Index (BMI) and the peripapillary RNFL thickness, IOP or CCT when OSAS group was divided by severity.Conclusions:The study results suggest that peripapillary RNFL thickness, IOP or CCT did not differ significantly between OSAS and control groups. We also found no correlation between apnea severity (AHI), lowest oxygen saturation (LAST) and BMI and RNFL, CCT and IOP.

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Section: Discussioncontrasting

confidence: 66%

Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Teberik¹,

Eski²,

Balbay³

et al. 2018

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…Second, the change in CCT may also affect IOP measures. Some research has shown that the CCT increased after exposure to high altitudes [7][19] [20]. It is known that IOP can be overestimated when the CCT is increased and underestimated when it is decreased.…”

Section: Discussionmentioning

confidence: 99%

“…A high altitude has diverse systemic and ophthalmic effects on individuals. Ophthalmic effects include changes in IOP [5] [7], the tear film [8], cornea [7], choroid [9] and retina [10] [11] [12]. Government staff members that were sent to the highlands from the lowlands, have complained about blurred vision in Lhasa.…”

Section: Introductionmentioning

confidence: 99%

Intraocular pressure and axial length changes during altitude acclimatization from Beijing to Lhasa

Liu

et al. 2020

PLoS ONE

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To investigate changes in intraocular pressure (IOP) and axial length (AL) on the ascent to high altitude from Beijing to Lhasa. Patients and methods Twenty volunteers (17 men, 3 women) who had been sent to work in Lhasa, Tibet for more than 6 months were enrolled. One of their journeys from Beijing to Lhasa was chosen as the time for the examination. IOP, AL, corneal curvature (K), and blood pressure (BP) were measured in Beijing (altitude 43 m) and Lhasa (altitude 3658 m). Their first examination was conducted at least 1 day before arriving in Lhasa and the second examination after they had stayed in Lhasa for 7 days. The data from the highland and lowland examinations were analyzed with a paired-sample T test and Pearson's correlation coefficient was calculated for the association between IOP and average BP. Results The mean IOP was 12.65±2.34 mmHg in Beijing and 14.85±3.1 mmHg in Lhasa. The mean AL was 24.61±1.50mm in Beijing, and 24.98±1.45 mm in Lhasa. The IOP and AL showed a significant elevation in highland compared with lowland (P<0.05). The mean K was 43.58 ±2.25 D in Beijing and 43.56±2.21 D in Lhasa and no significant difference was found in this study (P>0.05). A positive correlation between variance of IOP and ACD was found (r = 0.475, P<0.05) and no correlation between IOP and average BP was noted. Conclusions High altitude may lead to a small but significant change in IOP and axial length. However, the shape of the corneal surface was not influenced by the hypobaric and hypoxic conditions.

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“…Till date, many lesions in the eyes have been detected in relation with high altitude such ascorneal edema, tear film alterations, pupil defects, changes in the IOP [5,6] but there's no clear relation between them and the severe forms of mountain sickness [7]. The purpose of this article is to present a case of spontaneous resolution of this disease.…”

Section: Purposementioning

confidence: 99%

High Altitude Retinal Hemorrhage

Borrone¹,

Torres²

2017

J Clin Exp Ophthalmol

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Objective: sudden atmospheric pressure changes can generate vascular modifications in the retina. We present a clinical case of retinal hemorrhage related to high altitude and propose to revise its pathophysiology. Methods:A case presentation with review of literature.Results: 36 year old Male patient came to our institute with sudden diminished vision in the right eye associated with loss of consciousness while climbing a mountain. In the ophthalmological examination, we could appreciate in the right eye a macular hemorrhage and in both eyes few diffuse hemorrhages in mild periphery. The patient lost follow-up and return after 1 year for a check-up. He had spontaneous resolution of all hemorrhages.Conclusion: the acute mountain sickness affects mostly not climatized people. Changes in atmospheric pressure generate reduction of the partial pressure of oxygen in the blood. This can lead to vascular changes in the retina. This change may not appear if there is a proper climatization while climbing a mountain. The presence of high altitude retinopathy alerts about cerebral oedema related to high altitude.

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Changes in Central Corneal Thickness, Intraocular Pressure, and Oxidation/Antioxidation Parameters at High Altitude

Cited by 18 publications

References 18 publications

Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Intraocular pressure and axial length changes during altitude acclimatization from Beijing to Lhasa

High Altitude Retinal Hemorrhage

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