“…Compression of the median nerve can result from mechanical impingement or increased hydrostatic pressure, both of which have been shown to occur with deviation from a neutral wrist posture (Smith et al, 1977;Gelberman et al, 1981;Rojviroj et al, 1990;Weiss et al, 1995;Keir et al, 1997;Werner et al, 1997;Luchetti et al, 1998). It has also been demonstrated that the cross-sectional area (CSA) of the carpal tunnel changes with deviation from a neutral wrist posture (Skie et al, 1990;Yoshioka et al, 1993;Allmann et al, 1997;Bower et al, 2006). Changes in carpal tunnel pressure are a function of tunnel volume as well as the volume of its contents.…”