Changes in cardiac performance and sympathetic stimulation during and after fractionated radiotherapy in a rat model

Wondergem, J.; Franken, Nicolaas A.P.; Laarse, A. van der; Persons, C.C.M.; Ravels, F.J.M. Van; Reijnart, I.C.W.; Strootman, Erwin G

doi:10.1016/0167-8140(95)01161-7

Cited by 9 publications

(7 citation statements)

References 27 publications

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“…Lauk (1987) showed a decrease of capillary density and alkaline phosphatase activity in rat hearts within 1 month after irradiation before myocardial degeneration or clinical symptoms of heart disease became manifest. Several other irradiation-induced biochemical changes in myocardial energy metabolism and sympathetic regulation of the heart have been documented in our laboratory (Franken et al 1992;Wondergem et al 1996). It is striking that the biochemical changes we observed precede the myocardial degeneration and clinical symptoms of heart disease by several months.…”

Section: Discussionmentioning

confidence: 56%

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

Franken

Strootman

Hollaar

et al. 2000

J Cancer Res Clin Oncol

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Plasma levels of myocardial enzymes present after local heart irradiation were studied in a rat model. The purpose was to investigate whether, within days after irradiation, these enzyme levels change to such an extent that they may be helpful in assessing the severity of cardiac damage after radiotherapy. Therefore, activities of creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) were determined in the plasma and left ventricular myocardium of rats following local heart irradiation with a single dose of 20 Gy. A dose of 20 Gy is known to cause irreversible cardiac damage and to reduce survival times of the animals. Cardiac enzyme assays were performed directly after and twice daily for up to 2 weeks after radiation. Plasma CK, LDH, AST and alpha-HBDH levels were increased between 2 h and 24 h after irradiation. Plasma ALT levels remained unchanged. Myocardial enzyme levels, measured between 24 h and 16 days after radiation, did not differ between irradiated and control animals, although acute (first 12 h) reductions were observed in the irradiated group. The elevated enzyme levels in plasma appeared to correlate with the acutely reduced myocardial enzyme levels. Although irradiation with a dose of 20 Gy induced acute rises of cardiac enzyme levels in plasma, it is doubtful that fractionated radiation, as applied clinically for treatment of solid tumors, will induce plasma enzyme elevations that are large enough to indicate the extent of cardiac damage occurring acutely or chronically.

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Section: Discussionmentioning

confidence: 56%

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

Franken

Strootman

Hollaar

et al. 2000

J Cancer Res Clin Oncol

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“…Cardiac output (CF + AF) was measured by timed collection at increasing left atrial filling pressure (LAFP: 0-2.5 kPa). As a measure of cardiac performance, the integral of the whole Frank-Starling curve between LAFP of 0.5-2.5 kPa was used (21). The aortic pressure was kept at a fixed level of 9.0 kPa.…”

Section: E6aluation Of Coronary and Aortic Flow Using The Isolated Womentioning

confidence: 99%

Effects of Amifostine on Radiation-induced Cardiac Damage

2003

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“…Interestingly, the expression of NR4A1/2 in the heart is also induced by β-adrenergic stimulation (31,32). Local heart irradiation alters β-adrenergic signaling in the rat (33,34). Moreover, in the heart there is cross-talk between cardiac sensory and adrenergic nerves (35).…”

Section: Discussionmentioning

confidence: 99%

Roles of Sensory Nerves in the Regulation of Radiation-Induced Structural and Functional Changes in the Heart

Sridharan

Tripathi

Sharma

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

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Purpose Radiation-induced heart disease (RIHD) is a chronic severe side effect of radiotherapy of intrathoracic and chest wall tumors. The heart contains a dense network of sensory neurons that are not only involved in monitoring of cardiac events such as ischemia/reperfusion, but also play a role in cardiac tissue homeostasis, preconditioning, and repair. The purpose of this study was to examine the role of sensory nerves in RIHD. Methods and Materials Male Sprague-Dawley rats were administered capsaicin to permanently ablate sensory nerves, two weeks before local image-guided heart X-ray irradiation with a single dose of 21 Gy. During the 6-months follow up time, heart function was assessed with high resolution echocardiography. At 6 months after irradiation, cardiac structural and molecular changes were examined with histology, immunohistochemistry, and Western-Blots. Results Capsaicin-pretreatment blunted the effects of radiation on myocardial fibrosis and mast cell infiltration and activity. On the other hand, capsaicin-pretreatment caused a small but significant reduction in cardiac output at 6 months after irradiation. Capsaicin did not alter the effects of radiation on cardiac macrophage number or indicators of autophagy and apoptosis. Conclusions These results suggest that sensory nerves, while playing a predominantly protective role in radiation-induced cardiac function changes, may eventually enhance radiation-induced myocardial fibrosis and mast cell activity.

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Changes in cardiac performance and sympathetic stimulation during and after fractionated radiotherapy in a rat model

Cited by 9 publications

References 27 publications

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

Effects of Amifostine on Radiation-induced Cardiac Damage

Roles of Sensory Nerves in the Regulation of Radiation-Induced Structural and Functional Changes in the Heart

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