Changes in Cardiac Membranes as a Function of Age with Particular Emphasis on Reactivity to Drugs

Roberts, Jay; Goldberg, Paula B.

doi:10.1007/978-1-4615-9032-3_7

Cited by 13 publications

(1 citation statement)

References 19 publications

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“…However, other authors [10][11][12] found an age-dependent decrease of tissue catecholamine levels and other markers of the catecholaminergic innervation. Some variations of the norepinephrine metabolism were found in the heart of aged rats [13] and/or in cardiac membranes of old rats [14]. Finally, the amount of catecholamines shows age-related changes in some peripheral organs of male and female rats [15].…”

Section: Introductionmentioning

confidence: 90%

Age-Related Changes in Catecholaminergic Nerve Fibers of Rat Heart and Coronary Vessels

et al. 2003

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Background: Age-related changes of catecholaminergic nerve fibers supplying the myocardium and the coronary vessels were studied in adult and in old rats. Objective: The purpose of this study was to investigate whether there are quantitative changes in myocardial and/or coronary catecholaminergic nerve fibers and related neurotransmitters. Methods: Samples of myocardium and/or coronary vessels were studied by means of glyoxylic acid induced fluorescence, aldehyde-induced fluorescence, and neuropeptide Y immunoreactivity. All morphological results were submitted to quantitative analysis of images. Biochemical dosage of proteins and of norepinephrine was also performed, and morphological data were compared with biochemical ones. Finally, all data were subjected to statistical analysis. Results: Our findings are indicative of an age-related decrease of all types of fluorescent sympathetic nerve fibers in rat heart and coronary arteries. Moreover, our data show that aging induces a strong decrease of norepinephrine levels in tissue homogenates of rat heart and coronary vessels. The majority of the catecholaminergic nerve fibers that show strong age-related changes are not contiguous with contractile cells of myocardium and/or of vascular wall. In fact, these fibers are located in adventitial (or epicardial) and in endothelial (or endocardial) layers. Conclusion: The decrease of the catecholaminergic innervation of heart and coronary vessels of old rats can be in close relationships to the poor cardiac and/or coronary functions observed in old animals.

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