Changes in bronchial responsiveness following nasal provocation with allergen

Corren, Jonathan; Adinoff, Allen; Irvin, Charles G.

doi:10.1016/0091-6749(92)90329-z

Cited by 252 publications

(160 citation statements)

References 30 publications

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“…Patients with SAR develop seasonal increases in nonspecific bronchial responsiveness (BR) but not necessarily asthma symptoms, and these patients often have normal BR during the winter months [177]. BR is also increased in viral rhinitis [178,179] and following nasal allergen challenge [180,181]. These observations suggest that bronchial inflammation is associated with nasal inflammation, and is supported by the fact that bronchial hyperreactivity is reversed by intranasal treatment with sodium cromoglycate [182] and corticosteroids [38,183].…”

Section: Co-morbid Associationmentioning

confidence: 49%

BSACI guidelines for the management of allergic and non‐allergic rhinitis

Scadding

Durham

Mirakian

et al. 2007

Clin Experimental Allergy

348

292

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SummaryThis guidance for the management of patients with allergic and non-allergic rhinitis has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is for use by both adult physicians and paediatricians practicing in allergy. The recommendations are evidence graded. During the development of these guidelines, all BSACI members were included in the consultation process using a web-based system. Their comments and suggestions were carefully considered by the SOCC. Where evidence was lacking, consensus was reached by the experts on the committee. Included in this guideline are clinical classification of rhinitis, aetiology, diagnosis, investigations and management including subcutaneous and sublingual immunotherapy. There are also special sections for children, co-morbid associations and pregnancy. Finally, we have made recommendations for potential areas of future research.

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Section: Co-morbid Associationmentioning

confidence: 49%

BSACI guidelines for the management of allergic and non‐allergic rhinitis

Scadding

Durham

Mirakian

et al. 2007

Clin Experimental Allergy

348

292

View full text Add to dashboard Cite

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“…air to the nasal mucosa of healthy subjects 24 and histamine 25 or antigenic material 26 to the nasal mucosa of subjects with allergic rhinitis and asthma provoked an immediate and substantial increase in airway resistance. A study of subjects with perennial asthma 27 demonstrated that mouth breathing during exercise led to a worsening of airway resistance that was abolished by exclusive nose breathing.…”

Section: Discussionmentioning

confidence: 99%

Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: A longitudinal study

Burgess

Walters

Byrnes

et al. 2007

Journal of Allergy and Clinical Immunology

203

131

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“…From a pathophysiological viewpoint, the bronchial mucosal inflammation does not differ between asthmatics and rhinitics, as confirmed by segmental bronchial challenge: in pure rhinitics and asthmatics there was no difference in eosinophil count, IL-5 and IL-10 generation in the bronchoalveolar lavage fluid [40]. Moreover, it is known that nasal challenge with allergen may result in increased BHR [41]. What is more surprising is that the segmental bronchial challenge also results in nasal inflammation [42].…”

Section: Allergic Asthma and Allergic Rhinitismentioning

confidence: 99%

Allergy and the lung

Passalacqua¹,

Ciprandi

2008

Clinical and Experimental Immunology

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SummaryAmong the 'allergic' conditions involving the lung, asthma is the more frequent and the most extensively investigated, although asthma itself may be caused by different disorders. The triggering event in allergic subjects is the reaction allergen-specific immunoglobulin E (IgE) that activates mast cells and initiates a complex and redundant inflammatory process, where cells, cytokines and adhesion molecules are involved at different stages. In fact, mucosal eosinophilic inflammation is one of the distinctive features of asthma and the particular T helper type 2 (Th2) phenotype of allergic patients favours it. In general, the clinical severity of asthma correlates well with the degree of inflammation. None the less, other phenomena such as non-specific bronchial hyperresponsiveness and remodelling intervene in the pathophysiology of allergic asthma. These phenomena are only partially inflammation-related. In particular, the remodelling of the bronchial wall seems to start very early in life and also seems to be a distinctive histological feature of the asthmatic bronchus. The recent introduction of biological treatments (monoclonal antibodies) has allowed elucidation of some of the pathogenic features of allergic asthma.

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Changes in bronchial responsiveness following nasal provocation with allergen

Cited by 252 publications

References 30 publications

BSACI guidelines for the management of allergic and non‐allergic rhinitis

BSACI guidelines for the management of allergic and non‐allergic rhinitis

Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: A longitudinal study

Allergy and the lung

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