Changes in brain volume in response to estradiol levels, amphetamine sensitization and haloperidol treatment in awake female rats

KB220Z™ a Pro-Dopamine Regulator Associated with the Protracted, Alleviation of Terrifying Lucid Dreams. Can We Infer Neuroplasticity-induced Changes in the Reward Circuit?

“…Moreover, the haloperidol-induced focal changes in functional connectivity were found to be the most strongly associated with ascending dopamine projections. Furthermore, in support of dopamine D2 receptor involvement of enhanced connectivity volume found in the present study with KB220Z, Madularu et al [ 27 ] reported that chronic administration of haloperidol reduced connectivity volume in awake, female rats.…”

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z

“…Moreover, the Haloperidol-induced focal changes in functional connectivity were found to be the most strongly associated with ascending dopamine projections. Further, in support of dopamine D2 receptor involvement in enhanced connectivity volume, in the present study with KB220Z, Madularu et al reported that chronic administration of haloperidol reduced connectivity volume in awake female rats [76]. …”

System‐specific activity in response to Δ9‐tetrahydrocannabinol: a functional magnetic resonance imaging study in awake male rats

“…Although statistical analyses were performed on 130 ROIs (Tables S1 and S2), we focused primarily on areas involved in pain and memory, based on the findings linking cannabis/THC to these processes. As such, BOLD activation maps were shown within the putative pain (Yee et al, 2015) and hippocampal neural circuits (Madularu et al, 2015a). Furthermore, we assessed BOLD activity in a putative CB 1 receptor circuit, coalescing ROIs shown to be rich in CB 1 receptors (Herkenham et al, 1991;Tsou et al, 1998Tsou et al, , 1999Pickel et al, 2004).…”

“…Detailed description of the acclimation and imaging protocols can be found elsewhere (Madularu et al ., ,b, , ; Kenkel et al ., ). Briefly, prior to the first imaging session, all rats were acclimated to the imaging system environment before being placed into the scanner itself, over five consecutive days.…”