Changes in brain levels of NE and 5-HT are not responsible for attenuation of audiogenic seizures by spinal cordotomy

Willott, James F.; Lints, Carlton E.; Nenja, Leonard H.

doi:10.1016/0091-3057(79)90076-5

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Neurochemical Correlates Of Audiogenic Seizure Susceptibility and Fit Development1

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2011

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“…The failure to replicate previously reported significant differences between the susceptible (DBA/2J) and nonsusceptible (C57BL/6J) mice in the brain monoamine levels at the age of peak seizure susceptibility (in DBAs) demonstrated the difficulties of the whole issue, which was probably due to different techniques used (Lints et al, 1980). The cordotomy and brain monoamine levels approach proved, as authors claimed (Willott et al, 1979), that NE and 5-HT are not responsible for attenuation of audiogenic seizures. These data demonstrate that inter species differences (mouse genotypes compared) could be responsible for differences in neurochemical changes during AE fit.…”

Section: Neurochemical Correlates Of Audiogenic Seizure Susceptibility and Fit Developmentmentioning

confidence: 92%