Changes in Bone Turnover Markers and Menstrual Function After Short-term Oral DHEA in Young Women with Anorexia Nervosa

Gordon, Catherine M.; Grace, Estherann; Emans, S. Jean; Goodman, Elizabeth; Crawford, Margaret H.; LeBoff, Meryl S.

doi:10.1359/jbmr.1999.14.1.136

Cited by 104 publications

(41 citation statements)

References 55 publications

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“…We found DHEAS concentrations to be positively correlated with weight, a finding which corroborates with results reported elsewhere, suggesting that this hormone is nutritiondependent [16,43]. There was also a positive correlation found between serum DHEAS and hip BMC, and bone area of both the hip and total body.…”

Section: Discussionsupporting

confidence: 92%

“…Within our gender groups, DHEAS levels were significantly below the threshold for age only in the female participants. DHEA replacement has been studied in young women with anorexia nervosa, a model illustrating the negative effects of malnutrition on bone [20,43], but to our knowledge, its role in skeletal health in CF has not been previously examined. Short-term DHEA replacement has been shown to decrease markers of bone resorption and increase bone formation in young women with anorexia nervosa [43].…”

Section: Discussionmentioning

confidence: 99%

“…DHEA replacement has been studied in young women with anorexia nervosa, a model illustrating the negative effects of malnutrition on bone [20,43], but to our knowledge, its role in skeletal health in CF has not been previously examined. Short-term DHEA replacement has been shown to decrease markers of bone resorption and increase bone formation in young women with anorexia nervosa [43]. In a 1-year study examining the effects of DHEA versus estrogen replacement therapy in these patients, the young women in the group receiving DHEA had significantly higher levels of BSAP, osteocalcin, and IGF-I than those in the group receiving standard therapy.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

et al. 2006

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Introduction-Patients with cystic fibrosis (CF) are known to be at risk for early osteoporosis, and the mechanisms that mediate bone loss are still being delineated. The aim of the present investigation was to investigate if a correlation exists in these patients between skeletal measurements by dual-energy x-ray absorptiometry (DXA) and two anabolic factors, dehydroepiandrosterone (DHEA) and insulin-like growth factor I (IGF-I), and proresorptive factors such as the cytokines interleukin-1β, tumor necrosis factor α, and interleukin-6.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

et al. 2006

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“…Indeed, DHEA stimulates human osteoblast cell proliferation through the androgen receptor and preliminary findings suggest that DHEA has both anabolic and anti-osteolytic properties. Longitudinal studies are needed to determine the long-term biological actions of this agent, including its effects on bone mass (30).…”

Section: Discussionmentioning

confidence: 99%

The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosa

M¹,

Morandé

Garcia-Centenera

et al. 2002

Eur J Endocrinol

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Objective: Profound osteopenia is a serious complication of anorexia nervosa (AN). The aim of this work was to study the effect of prolonged AN on lumbar spine bone mineral density (BMD) and to determine whether oral estrogen administration prevents bone loss in women with this disorder. Subjects and Methods: Thirty-eight amenorrheic women with AN (mean age: 17.3 years) were treated with estrogen (50 mg of ethinyl estradiol) and gestagen (0.5 mg of norgestrel) during 1 year. Clinical variations, biochemical indices and BMD were studied at three different time points, including after a period of amenorrhea of at least 12 months ðn ¼ 38Þ, after the administration of estrogens for 1 year ðn ¼ 22Þ, and after a 1-year follow-up period ðn ¼ 12Þ. Results: Initial mean BMD was significantly lower than normal (22:1^0:8 S.D.) and less than 22.5 S.D. below normal in 38% of the women with AN. The estrogen-treated group had no significant change in BMD even after the follow-up period and partial recovery of weight. Estradiol and total IGF-I levels were significantly lower throughout the study. All subjects had normal thyroxine (T 4 ) and TSH levels and calcium metabolism. However, total tri-iodothyronine (T 3 ) was decreased in all anorexic subjects in the first and second study points and were within normal limits after the follow-up period. Conclusions: (1) Estrogen replacement alone cannot prevent progressive osteopenia in young women with AN. (2) Other factors, such as the loss of weight, the duration of the amenorrhea and the low levels of total insulin-like growth factor-I (IGF-I) could contribute to the loss of bone mass in women with this disorder.

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“…DHEA has been shown to stimulate bone formation and decrease markers of bone resorption in adolescent females with AN. In a pilot study, Gordon et al 55 investigated the effect of short-term oral DHEA in young women with AN. Markers of bone resorption significantly decreased and markers of bone formation significantly increased.…”

Section: Osteoporosismentioning

confidence: 99%

Medical complications in adolescents with anorexia nervosa: A review of the literature

Katzman

2005

Int. J. Eat. Disord.

321

209

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Changes in Bone Turnover Markers and Menstrual Function After Short-term Oral DHEA in Young Women with Anorexia Nervosa

Abstract: Bone loss is a serious consequence of anorexia nervosa (AN).

Cited by 104 publications

References 55 publications

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosa

Medical complications in adolescents with anorexia nervosa: A review of the literature

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