Changes in Bone Mineral Density Following Treatment of Osteomalacia

Six-year follow-up of a characteristic osteolytic lesion in a patient with tumor-induced osteomalacia

“…However, to the best of our knowledge, this is the first time that such a long longitudinal observation of BMD variation has been carried out in patients with oncogenic osteomalacia. Our BMD results mirror those obtained following treatment of nutritional osteomalacia (14), even though in this last condition the rate of increase in vertebral and hip BMD seems to be more rapid in the initial few months.…”

Global vitamin D status and determinants of hypovitaminosis D

“…This widespread prevalence of vitamin D deficiency/ insufficiency has a deleterious effect on bone mineral homeostasis and peak bone mass achieved and may subsequently reflect as low BMD [20,42,47,52]. Intervention studies with vitamin D supplements are underway in several of these populations.…”

“…Rickets is still common in neonates whose mothers have low levels of vitamin D and where the sole nutrition of the infant is breast milk. Osteomalacia is a crippling albeit reversible condition, which continues to be common in parts of Asia like the Indian subcontinent [52]. Furthermore, hypovitaminosis D affects all age groups, from the newborn to the elderly, and is dependent on several lifestyle and environmental conditions.…”

A case of hypophosphatemic osteomalacia secondary to deferasirox therapy

“…Although the ALP levels had not normalized 6 months following dose reduction of deferasirox, elevated levels of ALP have been reported to persist for 9 months despite treatment in individuals with osteomalacia. (19) The patient denied any current bone pain or muscle weakness but did report mild, transient right hip pain several months earlier, corresponding to the pubic rami fractures noted on bone scan. The patient denied any history of rib pain.…”