Changes in body weight in patients with colorectal cancer treated with surgery and adjuvant chemotherapy: An observational study

Winkels, Renate M.; Snetselaar, Teunise; Adriaans, Anika; Warmerdam, Laurens J.C. van; Vreugdenhil, Art; Slooter, Gerrit D.; Straathof, Jan-Willem; Kampman, Ellen; Lieshout, Rianne van; Beijer, Sandra

doi:10.1016/j.ctarc.2016.09.002

Cited by 22 publications

(19 citation statements)

References 12 publications

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“…These finding is consistent with Renate study ( 23 ), in which, values are close to our population study. Our results confirm the association between CRC chemotherapy and weight loss, using patients BMI, the prevalence of underweight known an increase after CRC appearance.…”

Section: Discussionsupporting

confidence: 94%

Evaluation of Nutritional Status of Colorectal Cancer Patients from Algerian East Using Anthropometric Measurements and Laboratory Assessment

Negrichi¹,

Taleb²

2020

ijph

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Background: Chemotherapy may lead to cancer patient malnutrition, associated with reduced response, and increased complications to anticancer therapy. This study aimed to evaluate the nutritional status of Algerian colorectal cancer patients. Methods: This cross-sectional study was conducted during 2016-2017 at the Oncology departments from the Algerian East included 90 patients with colorectal cancer. For each patient, a questionnaire, anthropometric measurements and biochemical tests have been done. Results: The 50-59 yr and 60-69 age groups represented more than half of the population. Obesity and underweight were significantly higher in female patients according to their actual Body mass index (BMI). Prevalence of underweight increased after cancer diagnosis, while obesity prevalence has decreased significantly. The malnutrition classification based on Mid-upper-arm muscle circumference (MUAMC) and the triceps skinfold thickness (TST) has shown a significant higher prevalence of malnutrition among male patients than females. The classification of Nutrition risk index (NRI) has shown a significant high percentage of male patients having malnutrition. In our study, no significant differences were recorded for biochemical tests. Anemia recorded the higher prevalences for both sex compared to other deficiency. Hypoironemia prevalence’s was higher among male patients than females while hypokalemia and hypoproteinemia prevalence’s were higher in female patients. Conclusion: Malnutrition in CRC patients must be combated by early detection to decrease complications associated to cancer and chemotherapy.

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Section: Discussionsupporting

confidence: 94%

Evaluation of Nutritional Status of Colorectal Cancer Patients from Algerian East Using Anthropometric Measurements and Laboratory Assessment

Negrichi¹,

Taleb²

2020

ijph

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“…A large part of the present study population is overweight or obese at diagnosis, which is in line with other studies [5], who also show that weight gain during and after cancer treatment in specific cancer types (e.g. breast and colorectal cancer) is very common.…”

Section: Discussionsupporting

confidence: 92%

“…Before, during and after treatment, CRC survivors often suffer from nutrition-related symptoms such as changes in defecation, intestinal cramps, lack of appetite and unintended weight gain or weight loss [5,6], which have a negative impact on quality of life [7,8]. Dietary guidelines to alleviate these symptoms are available [6,7,9] and it is important that CRC survivors are able to access and follow this information in order to change their diet to improve their quality of life.…”

Section: Introductionmentioning

confidence: 99%

Colorectal cancer survivors’ beliefs on nutrition and cancer; correlates with nutritional information provision

Veen

Mols

Smeets

et al. 2019

Support Care Cancer

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Purpose To investigate CRC survivors' beliefs on nutrition and cancer and the association with nutritional information provision by (kind and number) of health professionals and to inquire about foods that CRC survivors believed either had a positive or negative influence on their cancer. Methods A total of 326 CRC survivors of an ongoing prospective cohort study filled out questionnaires 1 month after surgery on whether they had received nutritional information from health professionals. Also, their beliefs that nutrition influences (1) feelings of well-being, (2) complaints after treatment, (3) recovery and (4) cancer recurrence were investigated. Prevalence ratios were calculated (using Cox proportional hazard regression analysis) to study associations between information provision and the four beliefs adjusted for age, gender and cancer stage. Results Sixty-two percent of respondents received information about nutrition from one or more health professionals. Most respondents who received information strongly believe nutrition influences feelings of well-being (59%) and recovery after cancer (62%). Compared with those who did not receive information, respondents who received information from three professionals showed the strongest beliefs on the influence of nutrition on complaints after treatment (PR 3.4; 95% CI 1.6-7.4), recovery after treatment (PR 2.0; 95% CI 1.2-3.3) and recurrence (PR 2.8; 95% CI 1.3-6.2). Conclusion Nutritional information provision by health professionals positively influences the beliefs of CRC survivors on the influence of nutrition on cancer outcomes: stronger beliefs occur when respondents received information from three health professionals.

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“…Various cancer treatments impact weight changes over time. Weight fluctuates throughout the course of treatment and type of cancer . Some cancers induce more cachexia than others, and some GI cancers induce more digestive distress than others .…”

Section: Discussionmentioning

confidence: 99%

Predicting unintentional weight loss in patients with gastrointestinal cancer

Yoon

Kim

Kelly

et al. 2019

J cachexia sarcopenia muscle

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Background Unintentional weight loss is a major problem for patients with gastrointestinal (GI) cancers because it affects treatment, survival outcomes, and quality of life. To date, little is known about the trajectory of weight loss and the relationship between baseline body mass index (BMI), location of the cancer, and outcomes. The aims of this study were to investigate patterns of weight loss over time in patients with GI cancer according to BMI groups (low, normal, and high) and location of cancer. Methods We examined de‐identified electronic medical record data of 801 adults ( >2 1 years) with GI cancer using ICD‐9 codes (150–159). Descriptive statistics and linear mixed models were used to examine unintentional weight loss over time by BMI group (low, normal, and high) and to determine the effect of primary cancer site and patient characteristics on weight loss. Results The mean age of patients was 66.5 ± 11.9 years (21–95 years), with 58% male and 86% White. Mean weight loss over 3 years was 21.39 kg. At the first observation point, 7.8% were in the low BMI group, 30.1% were in the normal, and 62% were in the high group. At the end of observation, a majority of deaths (35.5%) occurred in the low BMI group (BMI < 20 kg/m 2 ). Significant weight loss was observed in patients with gastric ( t = −5.11, P < 0.001), oesophageal ( t = −4.18, P < 0.001), and pancreatic (35.8%, t = −3.58, P < 0.001) cancers. Predictors of weight change were gender ( F = 64.93, P < 0.001), cancer stage ( F = 7.28, P < 0.001), and site by days ( F = 8.24, P < 0.001). Weight loss rates were similar among the three BMI groups, but patterns were different based on primary cancer type as a function of days within each group. Conclusions Weight loss in patients with GI cancers has implications for survival. Patients with upper GI cancers experienced more weight loss and decreased survival rates compared with patients with lower GI cancers. Patients with a combination of upper GI cancer (oesophagogastric or pancreatic) and low baseline BMI had the fewest survival days and worst patient outcomes. Early intervention for weight management plays a critical role for improving the health outcomes and fatality rates of these patients.

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Changes in body weight in patients with colorectal cancer treated with surgery and adjuvant chemotherapy: An observational study

Cited by 22 publications

References 12 publications

Evaluation of Nutritional Status of Colorectal Cancer Patients from Algerian East Using Anthropometric Measurements and Laboratory Assessment

Evaluation of Nutritional Status of Colorectal Cancer Patients from Algerian East Using Anthropometric Measurements and Laboratory Assessment

Colorectal cancer survivors’ beliefs on nutrition and cancer; correlates with nutritional information provision

Predicting unintentional weight loss in patients with gastrointestinal cancer

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