Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants: II

Clark, William G.; Lipton, J. M.

doi:10.1016/0149-7634(86)90025-4

Cited by 90 publications

(18 citation statements)

References 473 publications

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“…It has been well indicated that NA, and DA play important roles in regulation of the temperature in hypothalamus areas. For example, local injection of NA into PO/AH in rats cause to the increase of the body temperature (Clark & Lipton, 1986) and NA inhibits the activity of heat sensitive neurons in PO/ Ah (Watanabe, Morimoto, & Murakami, 1986). These findings show that NA is involved in the heat production mechanism.…”

Section: Temperature and Central Fatiguementioning

confidence: 65%

Role of Central Fatigue in Resistance and Endurance Exercises: An Emphasis on Mechanisms and Potential Sites

Sadri¹,

Khani²,

Sadri³

2014

sgia

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SUMMARYAn exercise-induced reduction in maximal force production, or the inability to continue an activity with enough force, is defined as fatigue. Although the etiology of fatigue is complex, it can be divided into two distinct components: central and peripheral. Central fatigue is the progressive exerciseinduced loss of the voluntary activation, or decrease in the neural stimulation, of the muscle, thereby reducing maximal force production. Considering the different mechanisms of strength and endurance activities as well as previous research, the authors suggest that there is peripheral fatigue in both kinds of activities. However, the mechanisms of fatigue and the rate of perceived exertion are distinct (mentally, endurance exercise is more difficult). An analysis of fatigue kinetics shows that peripheral fatigue occurs initially, and the central nervous system tries to prevent the disorder via output force through the perceptions of the metabolic condition of the muscle and the activation of additional motor units. Once peripheral fatigue surpasses a certain amount, the central nervous system reduces the number of activated motor units to prevent serious disorders in homeostasis and muscle damage, and protects the central governor. Still, in important and critical situations such as the final stages of running a marathon (when the last flight of runners is observed) and fight-or-flight situations in which someone faces a worse outcome if a task is abandoned, humans can choose one of worse or the worst alternatives to write their final destiny.

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Section: Temperature and Central Fatiguementioning

confidence: 65%

Role of Central Fatigue in Resistance and Endurance Exercises: An Emphasis on Mechanisms and Potential Sites

Sadri¹,

Khani²,

Sadri³

2014

sgia

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“…Loprinzi et al [48] reported a 50% reduction in hot flashes after 4 weeks of venlafaxine treatment in cancer survivors. These clinical reports investigating the role of SSRIs and SNRIs, our current findings and an extensive body of literature [1,49,50,51,52] suggest that temperature homeostasis is maintained by a delicate interplay between serotonergic and noradrenergic signaling.…”

Section: Discussionmentioning

confidence: 99%

The Role of the Selective Serotonin Reuptake Inhibitor Fluoxetine in Temperature Regulation in Ovariectomized Rat Models

et al. 2006

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Thermoregulation is an integrated network of neuroendocrine, autonomic and somatosensory responses. Thermoregulatory dysfunction occurs during fluctuations or decline of gonadal hormone levels and results in vasomotor symptoms such as hot flushes and/or night-time sweating. The neurotransmitter serotonin (5-HT), has been reported to play a role in thermoregulation via changes in extracellular 5-HT levels and/or activation of various 5-HT receptors. The purpose of this study was to evaluate the role of the selective 5-HT reuptake inhibitor (SSRI), fluoxetine (FLX), on temperature regulation using ovariectomized (OVX) rodent models of thermoregulation. Single, subcutaneous (s.c.) administration of FLX (3, 10, 30 and 60 mg/kg) dose-dependently reduced core body temperature (CBT). FLX at 3 and 10 mg/kg s.c. showed no statistically significant decrease on tail-skin temperature (TST), whereas at higher doses (30 and 60 mg/kg) a significant decrease in TST was noted in the telemetry model. To mimic chronic SSRI treatment, a 5-HT_1A antagonist (WAY-100635; 0.3 mg/kg) was administered 20 min prior to FLX (10 mg/kg). This combination showed no significant improvement on temperature dysfunction compared to FLX alone. Similarly, in a morphine-dependent model of temperature dysfunction FLX, was inactive at 10 mg/kg whereas the 30 and 60 mg/kg s.c. dose abated the naloxone-induced increase in TST by 55 and 81%, respectively. In summary, FLX affected CBT at all doses, but alleviated thermoregulatory dysfunction only at higher doses that are non-selective for the 5-HT system.

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“…It has been speculated that, compared to amphetamine, the most pronounced serotonergic action of 4-MA could diminish the psychoactive effects of amphetamine leading to the consumption of repeated and higher doses of contaminated amphetamine [2]. Serotonin (5-HT) in the hypothalamus is involved in the regulation of body temperature [6]. Stimulation of 5-HT 2 receptors in hypothalamic neurons mediates hyperthermic effects, whereas stimulation of the 5-HT 1A receptors in these neurons inhibit the endogenous release of hypothalamic 5-HT and leads to hypothermic effects [7,8].…”

Section: Introductionmentioning

confidence: 99%

Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats

Rubio

López-Arnau

Piccoli

et al. 2015

Neuroscience Letters

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Abstract4-methylamphetamine (4-MA) has recently emerged as a designer drug of abuse in Europe and it is consumed always with amphetamine. There have been reported some deaths and non-fatal intoxications related to 4-MA. We investigated the changes in locomotor activity and body temperature after 4-MA administration to male SpragueDawley rats. Our experiments were carried out at a normal or high ambient temperature. 4-MA (2.5 -10 mg/Kg, given subcutaneously) increased, in a dosedependent manner, the horizontal locomotor activity that was significantly reduced by ketanserin, p-cholorophenylalanine (pCPA) or haloperidol. In addition, we have studied the effect of 4-MA on core body temperature by means of an implanted electronic thermograph, enabling continuous measurement of body temperature. We observed a dose-dependent hypothermic response to 4-MA that reached a maximum 45 min after a single injection. We also evidenced slight tachyphylaxis to the hypothermic effect when 4-MA was administered four times in a 2 h interval. The pre-treatment of animals with pCPA or pindolol, but not with ketanserin, fully abolished the hypothermic effect of 4-MA. With all that, we conclude that hypothermia induced by 4-MA is due to the release of 5-HT which activates postsynaptic 5-HT 1A receptors.

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Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants: II

Cited by 90 publications

References 473 publications

Role of Central Fatigue in Resistance and Endurance Exercises: An Emphasis on Mechanisms and Potential Sites

Role of Central Fatigue in Resistance and Endurance Exercises: An Emphasis on Mechanisms and Potential Sites

The Role of the Selective Serotonin Reuptake Inhibitor Fluoxetine in Temperature Regulation in Ovariectomized Rat Models

Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats

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