Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss

Martos, Rosario; Valle, Miguel; Morales, Rosario; Cañete, Ramón; Gascón, Félix; Urbano, Maria M.

doi:10.1016/j.metabol.2009.03.017

Cited by 31 publications

(30 citation statements)

References 52 publications

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“…21 Positive short-term effects of a reduction in BMI in obese prepubertal children have been shown to reduce insulin resistance. 3 We also found in this cohort, at the end of the intervention program, a clear correlation between a decrease in BF% and an increase in insulin sensitivity. 22 Moreover, sustained beneficial effects of obesity treatment programs on lipid profile and markers for insulin sensitivity have been demonstrated in obese 8-year-old to 16-yearold children.…”

Section: Discussionsupporting

confidence: 68%

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Three-year follow-up of 3-year-old to 5-year-old children after participation in a multidisciplinary or a usual-care obesity treatment program

et al. 2014

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Section: Discussionsupporting

confidence: 68%

“…2 In obese children, a decreased insulin sensitivity and dyslipidemia have been described at a young age. 3,4 Childhood obesity may persist into adulthood, 5 potentially leading to the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). 6,7 Prevention of childhood obesity should have a high priority.…”

Section: Introductionmentioning

confidence: 99%

Three-year follow-up of 3-year-old to 5-year-old children after participation in a multidisciplinary or a usual-care obesity treatment program

et al. 2014

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“…50 BMI-SDS reduction is correlated with changes in sICAM-1 levels both in children and adults. 55 In adults, BMI and obesity are correlated with sICAM-1 levels, while at the same time BMI and obesity reduction result in lowering both ICAM-1 and VCAM-1.…”

mentioning

confidence: 88%

“…Although uncertain, it is plausible that higher visceral adipose tissue in Caucasians compared to African Americans may in part explain this racial differential in endothelial biomarkers. 49 In recent studies, obese children displayed significantly elevated sICAM-1, IR 50 and C-reactive protein (CRP) values. 22,43,51 A correlation between the adhesion molecules 52 and 8-iso-PGF2 factor (index of oxidative stress, endothelial and platelet activation) was also observed, revealing that early endothelial and platelet activation occurs in obese children.…”

mentioning

confidence: 99%

Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children. Do they play a role in the progression of atherosclerosis?

Fotis¹,

Giannakopoulos²,

Stamogiannou³

et al. 2012

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“…Recent studies demonstrated that weight loss in obese children aged 6-11 y also reduced low-grade inflammation and IR (4,8). In obese children, 9-13 y old, weight loss over a 1-y period led to a significant decrease in triglyceride (TG) concentrations and an improvement of an indicator of insulin sensitivity, the homeostasis model assessment of IR (HOMA-IR) (7).…”

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confidence: 99%

Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children

et al. 2013

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Background: Childhood obesity can cause the development of cardiovascular risk factors. We assessed the effect of a multidisciplinary intervention program on cardiovascular risk factors and compared this effect with a usual-care program in 3-to 5-y-old overweight or obese children. Methods: Seventy-five children were randomly assigned to a multidisciplinary intervention or a usual-care program. Anthropometry, body composition, and abdominal adipose tissue were assessed at the start and end of a 16-wk program. Concurrently, fasting concentrations of serum lipids, glucose, insulin, HbA1c, leptin, adiponectin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were determined. results: In both groups, insulin sensitivity improved, demonstrated by decreased insulin concentrations and a decreased HOMA2-IR. In the multidisciplinary intervention group, there was also a decrease of HbA1c and TNF-α. In the usual-care group, an increase in glucose concentrations was found. Comparing both groups, changes over time were not different, besides trends in the decrease in total cholesterol and TNF-α, in favor of the multidisciplinary intervention group. Combining the results of both groups, a correlation was found between the decrease in body fat percentage (BF%), and both HOMA2-IR and triglyceride (TG) concentrations. conclusion: In 3-to 5-y-old children, both obesity intervention programs improved insulin sensitivity, in parallel with a reduced BF%. r ecent data have shown that the prevalence of childhood overweight and obesity in the Netherlands is still increasing (1). Childhood obesity is a risk factor for the development of insulin resistance (IR), dyslipidemia, and hypertension at a later age, together described as metabolic syndrome (MS) (2). MS cannot be diagnosed in children under the age of 10 y (3). However, increased concentrations of the separate components of MS have already been demonstrated in children aged 6-9 y (4).Systemic low-grade inflammation may be an underlying cause of MS, induced by the release of inflammatory cytokines from adipose tissue, and even more so from visceral adipose tissue (5,6). Increased concentrations of tumor necrosis factor (TNF)-α, high-sensitive C-reactive protein (hsCRP), and interleukin (IL)-6 have been found in obese children aged 9-13 y (7,8). The adipose tissue hormone adiponectin has anti-inflammatory properties, demonstrated by the significant inverse correlation with markers of inflammation in obese children (8). Whether these deleterious processes related to obesity are already present in overweight and obesity at a very young age is unknown, and no data on systemic low-grade inflammation are available in very young obese children.Multidisciplinary lifestyle intervention programs for obese children have proven to be successful in reducing weight (9). Recent studies demonstrated that weight loss in obese children aged 6-11 y also reduced low-grade inflammation and IR (4,8). In obese children, 9-13 y old, weight loss over a 1-y p...

show abstract

Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss

Cited by 31 publications

References 52 publications

Three-year follow-up of 3-year-old to 5-year-old children after participation in a multidisciplinary or a usual-care obesity treatment program

Three-year follow-up of 3-year-old to 5-year-old children after participation in a multidisciplinary or a usual-care obesity treatment program

Intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in children. Do they play a role in the progression of atherosclerosis?

Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children

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