Changes in blood glucose concentration are associated with relatively rapid changes in circulating fructosamine concentrations in cats

Link, Karl; Rand, J. S.

doi:10.1016/j.jfms.2008.08.005

Cited by 29 publications

(40 citation statements)

References 17 publications

(17 reference statements)

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“…In 1948, Dohan and Lukens administered large doses of glucose to normal cats and induced permanent hyperglycemia, hydropic degeneration of the islets of Langerhans, and ketonuria. It took nearly 50 years for those findings to be recognized in veterinary medicine when Link and Rand (1996) performed a similar experiment. They showed that insulin levels in healthy cats decreased within days when high blood glucose levels were maintained by glucose infusion.…”

Section: Remission Of Diabetes In Catsmentioning

confidence: 97%

“…They showed that insulin levels in healthy cats decreased within days when high blood glucose levels were maintained by glucose infusion. Several cats even became ketonuric and required 1 to 2 weeks of insulin therapy after cessation of the glucose infusion (Link and Rand, 1996;Link et al, 2013). The cellular mechanisms by which chronic hyperglycemia affects insulin secretion and insulin sensitivity are poorly understood.…”

Section: Remission Of Diabetes In Catsmentioning

confidence: 99%

See 1 more Smart Citation

Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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Section: Remission Of Diabetes In Catsmentioning

confidence: 97%

Section: Remission Of Diabetes In Catsmentioning

confidence: 99%

Feline Diabetes Mellitus

Reusch

2015

Canine and Feline Endocrinology

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“…O estresse crônico (superior a cinco dias) também demonstrou influência sobre os valores de frutosamina, entretanto estes animais, em média, também não apresentaram hiperglicemia, não devendo representar uma dificuldade na diferenciação de um possível DM. Este aumento da concentração sérica de frutosamina também se manteve dentro do intervalo de referência, como encontrado em estudos anteriores 4,10,12,16 .…”

Section: Discussão E Conclusõesunclassified

“…Na tentativa de se avaliar a média glicêmica para o controle do diabetes em gatos, as concentrações séricas seriadas de frutosamina trazem informações mais valiosas quando comparadas com uma única dosagem de frutosamina 4 . As frutosaminas são proteínas séricas glicadas continuamente formadas, resultantes da ligação não enzimática, irreversível e insulino-independente entre a glicose e proteínas circulantes.…”

Section: Introductionunclassified

Avaliação dos níveis de frutosamina em gatos sob estresse agudo e crônico

Moraes

Thomazini

Takahira

et al. 2011

Braz. J. Vet. Res. Anim. Sci.

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ResumoFrutosaminas são proteínas séricas glicadas formadas continuamente resultantes da ligação entre a glicose e proteínas circulantes, e correspondem à avaliação glicêmica de aproximadamente uma a duas semanas em gatos. A concentração de frutosamina tem sido utilizada para a diferenciação entre a hiperglicemia persistente e transitória induzida pelo estresse, sendo considerado o teste padrão ouro para o controle da glicemia em gatos diabéticos. O objetivo deste trabalho consistiu em avaliar a influência dos estados de estresse agudo e crônico em gatos sobre os níveis séricos de frutosamina. Foram selecionados 62 felinos provenientes do atendimento no Hospital Veterinário da FMVZ -UNESP Botucatu, distribuídos em três grupos: felinos com histórico de qualquer doença ou condições de estresse, excluindose o diabetes mellitus (DM), por um período máximo de 48 horas (Grupo A, n = 21) ou por um período superior a 120 horas (Grupo B, n = 27). O terceiro grupo (Grupo C = controle) foi formado por 14 felinos saudáveis. Os grupos foram avaliados quanto às dosagens séricas de frutosamina, glicose, proteína e albumina. Foi constatado um aumento significativo nos valores de frutosamina tanto nos animais submetidos ao estresse agudo quanto crônico, porém os níveis mantiveram-se dentro do intervalo de referência. Da mesma forma, os animais, em média, também se encontravam em normoglicemia, apesar da correlação positiva entre as concentrações de glicose e frutosamina. Conclui-se que a concentração de frutosamina sofre influência dos estados de estresse agudo e crônico em gatos, mantendo-se, porém, dentro dos limites de referência, sendo, portanto, útil no diagnóstico do DM. Palavras-chave:Frutosamina. Gato. Estresse. Glicemia. AbstractFructosamine are glycated serum proteins that are formed continuously due to the reaction between glucose and circulating proteins, and corresponding to the blood glucose control assessment over the last one to two weeks in cats. The fructosamine concentration has been used for differentiation between persistent and transient hyperglycemia. Therefore, the determination of fructosamine is considered the gold standard for monitoring glycemia into control in diabetic cats. The objective of this study was to evaluate the influence of acute and chronic stress of cats on serum fructosamine. 62 cats were selected from the Veterinary Hospital of FMVZ -UNESP, Botucatu campus. They were distributed into three groups: cats with a history of any illness or stress condition, excluding Diabetes Mellitus (DM), for a maximum of 48 hours (Group A, n = 21) or for a period exceeding 120 hours (Group B n = 27). The third group (Group C = control) was formed by 14 health cats. The groups were evaluated for serum fructosamine, glucose, protein and albumin. In this study, there was a significant increase in the values of fructosamine in animals subjected to acute and chronic stress, but these values remained within the reference range. The animals were, on average, normoglycemic, despite the positive correlation betwee...

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“…Additionally, the range of fructosamine concentrations associated with a given glucose concentration was wide, with the critical difference for fructosamine being 33 µmol/l 178 . Differences in serial measurements of less than 33 µmol/l may not be indicative of fluctuations in blood glucose measurements.…”

Section: Fructosaminementioning

confidence: 99%

Screening for prediabetes in senior cats and metabolomic characteristics of obesity and Burmese cats

Reeve-Johnson¹

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Type 2 diabetes is the most common form of diabetes in humans and cats, and senior age and obesity are major risk factors. Diabetes is typically diagnosed in cats once clinical signs are evident. In humans, prediabetes is a metabolic state between normal glucose homeostasis and diabetes, and is diagnosed by demonstrating impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG). However, prediabetes has not yet been defined in cats, and reference values for these variables have not been reported for senior cats.In this thesis, the first experiment investigated if the current practice of dosing glucose by bodyweight results in spurious effects on measures of glucose tolerance in obese cats.Glucose data from glucose tolerance and insulin sensitivity tests were analysed before and after 16 cats were fed ad libitum for 9 -12 months to promote weight gain. Bodyweight and body condition score (BCS) were positively correlated with 2-min, 2-h glucose concentrations and glucose half-life following a glucose tolerance test (GTT) when glucose dosing was by bodyweight. To avoid obese cats being incorrectly classified as having impaired glucose tolerance when glucose was dosed on a bodyweight basis, equations were developed to adjust either glucose dose or 2-h glucose to compensate for obesity. This has important implications for clinical studies assessing the effects of interventions on glucose tolerance when lean and obese cats are compared.The second experiment established methodology and cutpoints for fasting and 2-h glucose during a GTT in healthy, client-owned senior cats (> 8yrs, n=78), by using ear/ paw samples and a portable glucose meter calibrated for feline blood. Fasting blood glucose was measured from ear/paw samples and glucose (0.5 g/kg bodyweight) administered IV, followed by blood glucose measurements at 2 min and 2 h. Cutpoints for fasting and 2-h glucose concentrations iii were established as the upper limits of 95% reference intervals using cats with BCS 4 or 5 on a 9-point scale and were 6.5 mmol/L for fasting glucose and 9.8 mmol/L for 2-h glucose.The third experiment established a methodology and reference interval for screening blood glucose in senior cats. Blood glucose was measured at the beginning of the consultation in clinically healthy cats (≥8 years, n=120) from an ear/ paw sample using a portable glucose meter, and again after physical examination from a jugular sample. The cutpoint for screening blood glucose was 10.5 mmol/L. Mean screening blood glucose was greater than mean fasting glucose. Based on these results, it is recommended that cats with screening blood glucose from 6.5 mmol/L to 10.5 mmol/L be retested several hours later, and cats with screening values >10.5 mmol/L or a second test > 6.5 mmol/L should have fasting and 2-h blood glucose measured after overnight hospitalization.Metabolomic markers of obesity and prediabetes have been investigated in humans, but there is limited data available in cats. Additionally, there is limited research on metabolomics in ...

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Changes in blood glucose concentration are associated with relatively rapid changes in circulating fructosamine concentrations in cats

Cited by 29 publications

References 17 publications

Feline Diabetes Mellitus

Feline Diabetes Mellitus

Avaliação dos níveis de frutosamina em gatos sob estresse agudo e crônico

Screening for prediabetes in senior cats and metabolomic characteristics of obesity and Burmese cats

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