Changes in Blood Factors and Ultrasound Findings in Mild Cognitive Impairment and Dementia

Cho, Kyoungjoo; Kim, Jihye; Kim, Gyung Whan

doi:10.3389/fnagi.2017.00427

Cited by 5 publications

(10 citation statements)

References 42 publications

(59 reference statements)

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“…Mean Difference of CIMT in Patients with and without CI Of the 12 included studies [26][27][28][29][30][31][32][33][34][35][36][37], 9 [26-30, 32-34, 37], provided data for the main analysis of CIMT in pa- tients with CI and NCI involving 6,312 subjects, 1,089 with CI, and 5,223 with NCI. Included studies had sample sizes ranging from 53 [37] to 3,386 [32].…”

Section: Meta-analysis Of Resultsmentioning

confidence: 99%

The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis

Fresnais

Humble

Bejerot

et al. 2021

Dement Geriatr Cogn Disord

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Background: Emerging evidence suggests that cognitive impairment (CI) and different etiologies of dementia, including Alzheimer’s disease (AD), are associated with vascular risk factors and atherosclerosis. In clinical practice, carotid intima-media thickness (CIMT) measured by ultrasonography may be a marker of atherosclerosis. Many studies report increased CIMT in patients with dementia and CI although a firm association has not yet been established. Aim: This systematic review and meta-analysis were conducted to study the relationship between CIMT, dementia, and CI. Methods: The literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and included the following databases: Medline, Embase, Cochrane Library, and Epistemonikos. The search spanned from 2000 to 2020 and was limited to English and Scandinavian languages. Results: The main analysis of CIMT in subjects with CI compared to subjects with no cognitive impairment (NCI) included 12 studies; 1,089 subjects with CI and 5,223 with NCI. There was no significant difference in CIMT between the CI and NCI groups. However, subgroup analyses revealed significantly higher CIMT in the mild cognitive impairment (MCI) and dementia groups than the NCI group. In addition, patients with dementia had increased CIMT compared to patients with MCI, and patients with AD demonstrated higher CIMT than those with vascular cognitive impairment (VCI). Conclusion: CIMT may be higher in subjects with CI than in cognitively healthy subjects although no significant difference was observed in our main analysis. CIMT was higher in the dementia group than the MCI group and in the AD group compared to the VCI group.

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Section: Meta-analysis Of Resultsmentioning

confidence: 99%

The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis

Fresnais

Humble

Bejerot

et al. 2021

Dement Geriatr Cogn Disord

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“…We assessed ultrasonography-based morphological characteristics as mean values of IMT and plaque numbers versus circulating factor-based functional changes in the two groups. Our previous investigations showed that there were no significant differences among detailed categorized IMT or plaque size (diameter) or plaque numbers [2]. Therefore, in this study, we used simple categories such as mean IMT and plaque numbers.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, it could progress to a specific atheroma at carotid bifurcation, where atheroma is mostly detected after local resection [14]. However, our previous investigations showed that there were no significant differences among detailed categorized IMT or plaque size (diameter) and plaque numbers [2].…”

Section: Introductionmentioning

confidence: 94%

“…Carotid artery atherosclerosis is associated with subsequent risk of new or recurrent cerebrovascular diseases, such as transient ischemic attack, stroke, and post-stroke vascular dementia, particularly in the modern day society [1][2][3][4][5]. With this association, several noninvasive measures for subclinical atherosclerosis have been undertaken in the predictive diagnosis of carotid and cerebrovascular diseases (CVDs).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating Factors and Ultrasono-findings are Linked to Previous Atherosclerotic Burden and Recurrent Risk

Cho

Kim

Jeon

et al. 2019

CPD

Self Cite

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Background: In the progression of atherosclerosis, platelet activation and the interaction of platelets with leukocytes play a crucial role in arterial thrombus formation and are associated with the pathophysiology of carotid and cerebrovascular disease (CVD), including ischemic stroke. With aged participants, we evaluated and followed up the change in circulating factor and platelet-leukocyte aggregate levels in participants with or without CVD history. This study investigated whether circulating factor changes and ultrasonographic characteristics link to CVD risk and other relating long-term outcomes. Materials & Methods: Two hundred fifteen participants who enrolled in the study were divided into two groups with CVD and without CVD history. We evaluated and analyzed the correlation between ultrasonography-based morphological characteristics and circulating factor-based functional changes in both groups. Results: There was no difference in p-selectin level between both groups. However, activated monocyte and platelet-monocyte aggregate levels were higher in patients with previous CVD than without previous CVD. Circulating factor and ultrasonographical characteristics were correlated in the group with CVD, whereas these factors were not correlated in the group without CVD. Conclusion: We found that circulating blood factor levels showed a different tendency in participants with and without CVD history. The results depict that atherosclerotic severity might depend on the history of CVD and progression of atherosclerosis. We suggest that the circulating factor levels, atherosclerotic severity, and history of CVD are considered in the observation of pathologic progression to manage the development of CVD risks and CVD relating outcomes.

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“…A recent meta-analysis investigation showed that hearing impairment is associated with a higher risk of MCI and dementia in elderly people [33].…”

Section: Genetic Typesmentioning

confidence: 99%

Updated Information on Some Cognitive Disorders

Sibat¹,

Valdés²

2019

Cognitive Disorders

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Dementia is a neurodegenerative disorder characterized by a progressive decline in cognitive and daily living activities. The present review aimed to highlight the most relevant and updated information available in the medical literature on mild cognitive impairment, Parkinson's dementia, Alzheimer's disease, vascular dementia, normal pressure hydrocephalus, and Wernicke-Korsakoff and to deliver some personal observations about cognitive disorders and dementia.

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Changes in Blood Factors and Ultrasound Findings in Mild Cognitive Impairment and Dementia

Cited by 5 publications

References 42 publications

The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis

The Association between Carotid Intima-Media Thickness and Cognitive Impairment: A Systematic Review and Meta-Analysis

Circulating Factors and Ultrasono-findings are Linked to Previous Atherosclerotic Burden and Recurrent Risk

Updated Information on Some Cognitive Disorders

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