Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)

Smucny, Darlene; Allison, David B.; Ingram, Donald K.; Roth, George S.; Kemnitz, Joseph W.; Kohama, Steven G.; Lane, Mark A.

doi:10.1111/j.1600-0684.2001.tb00005.x

Cited by 51 publications

(69 citation statements)

References 4 publications

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“…Therefore, all Macaca RBC levels are thought to be lower than that in humans [15]. MCH has been reported to show significantly lower values in cynomolgus monkeys than in humans, and a low value compared with rhesus monkeys [9, 18, 24, 25]. RBCs in cynomolgus monkeys thus appear to be less pigmented (Table 5).…”

Section: Discussionmentioning

confidence: 99%

Establishment of reference values for complete blood count and blood gases in cynomolgus monkeys (Macaca fascicularis)

Nakayama

Kanayama

Katakai

et al. 2017

The Journal of Veterinary Medical Science

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Cynomolgus monkeys are closely related to humans phylogenetically, and this has resulted in their widespread use as a preclinical model. Hematological data with regard to these monkeys are thus important. Although reference values for blood components and sex hormones have been established for cynomolgus monkeys, those for arterial blood gases have not. The arterial blood gases quickly reflect respiratory and circulatory dynamics, and are thus useful for animal management and safe general anesthesia and surgical operations. Furthermore, since O2 is transported by RBC, CBC and blood gases are closely related. The present study aimed to establish reference values for arterial blood gases and CBC in cynomolgus monkeys over a wide age range. Blood gases and CBC of arterial blood, collected from 41 female and 21 male anesthetized monkeys, were measured. Age correlated with RBC, HGB and HCT in the CBC. Values differed significantly between males and females in pCO2, CO2 concentration, MCV and MCH. The pH of blood was equivalent to that of humans and pCO2 was more stable, whereas MCV and MCH were lower than those in humans. Erythrocytes were smaller and less pigmented than in other Macaca species. Several relationships between gender and age, and blood gases and CBC were identified in cynomolgus monkeys. In conclusion, these reference values will be useful as markers for veterinary applications and in the care and maintenance of these animals.

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Section: Discussionmentioning

confidence: 99%

Establishment of reference values for complete blood count and blood gases in cynomolgus monkeys (Macaca fascicularis)

Nakayama

Kanayama

Katakai

et al. 2017

The Journal of Veterinary Medical Science

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“…Most of them are confined to rhesus monkeys (Macaca mulatta) [Buchl & Howard, 1997;Goodrich et al, 1995;Gotoh et al, 2001;Hassimoto et al, 2004;Herndon & Tigges, 2001;Mythili et al, 2005;Rogers et al, 2005;Smucny et al, , 2004. Only few reports are available on other species of monkeys; in particular, studies on the hematology of New-World species are scarce and always involve single or very few samples per animal [Boere et al, 2005;Malaga et al, 1995;Poleschuk et al, 1998;Riviello & Wirz, 2001;Rosner et al, 1986;Wirz et al, 2000;Yarbrough et al, 1984].…”

Section: Introductionmentioning

confidence: 99%

Hematological and plasma biochemical values for captive tufted capuchin monkeys (Cebus apella)

Wirz¹,

Truppa²,

Riviello³

2008

American J Primatol

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Hematological and blood biochemical parameters are of great importance in medical and veterinary practice. Unfortunately, normal reference range intervals for hematological and serum biochemical values in the tufted capuchin monkey (Cebus apella) have seldom been reported. The study reported here is based on data from blood samples collected from 44 monkeys over an 8-year period. Male and female data are displayed separately within two age categories: juveniles and adults, and effects for sex and age are examined. Significant differences between males and females are found for erythrocytes, hemoglobin, hematocrit, and α(1) globulin. Significant differences between juveniles and adults are found for neutrophils, calcium, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, inorganic phosphorus, glucose, total protein, serum iron, and some serum protein parameters and albumin/globulin ratio. These values are compared with values we previously reported, and their importance in care and well-being of captive tufted capuchin monkeys is discussed.

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“…A great deal is known about their general husbandry, nutritional requirements, breeding practices and veterinary care. As healthy rhesus macaques age, values for routine hematological and blood chemistry variables exhibit notable, biologically relevant changes that reflect normal patterns of the aging process (Smucny et al 2001). The rhesus macaque shares 97.5% genetic homology to humans (Gibbs et al 2007) and a maximum lifespan of 40 years (Ingram et al 1990;Roth et al 2004).…”

Section: Nonhuman Primate Modelsmentioning

confidence: 99%

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

Sitzmann

Urbanski

Ottinger

2008

AGE

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Although less dramatic than in females, male mammals experience decreasing reproductive function during aging. In primates, multiple facets of the hypothalamic-pituitary-gonadal axis show evidence of gradual age-related decline, including behavioral, neuroendocrine and endocrine alterations such as decreased testosterone levels, reduced circulating dehydroepiandrosterone sulfate (DHEAS) levels, increased numbers of sperm abnormalities, and a general decline in physiological responses. In this review we consider a range of age-related changes in males. These measures, including more subtle aging characteristics, are interesting additional indices for detecting the timing of age-related changes in behavioral, neuroendocrine, and endocrine responses. Evidence of potential effects of calorie restriction as an intervention in reproductive aging is also discussed. A discernable decline occurs in both metabolic and reproductive endocrine processes during male aging. This cascade of events includes neuroendocrine and behavioral changes; biomarkers such as circulating DHEAS also show clear age-related decline. The varied changes that occur during male aging are considered in the context of primate aging in general.

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Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta)

Cited by 51 publications

References 4 publications

Establishment of reference values for complete blood count and blood gases in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Establishment of reference values for complete blood count and blood gases in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Hematological and plasma biochemical values for captive tufted capuchin monkeys (Cebus apella)

Aging in male primates: reproductive decline, effects of calorie restriction and future research potential

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