Changes in biochemical markers following spinal manipulation-a systematic review and meta-analysis

The immediate effects of cervical spine manipulation on pain and biochemical markers in females with acute non-specific mechanical neck pain: a randomized clinical trial

“…Two of the strategies included expanding research focused on pain management and advancing better practices for pain management [7]. Due to the adverse side effects associated with prescription opioid usage, drug-free pain management strategies such as SM should be more readily considered for individuals with spinal pain [9]. SM is used by physical therapists and other healthcare practitioners as an intervention to help relieve spinal pain and reduce disability [2,3].…”

“…SM is used by physical therapists and other healthcare practitioners as an intervention to help relieve spinal pain and reduce disability [2,3]. SM has been shown to be an effective intervention for patients with non-specific mechanical neck pain (NS-MNP) [10], either alone or in combination with exercises as part of a multimodal management strategy [9,11,12].…”

“…There are a variety of observed and proposed phenomena that may explain the mechanisms for the psychological, mechanical, or neurophysiological responses from a SM associated with alterations in pain processing or sympathetic and motor systems' excitation [15,16]. Of these three mechanisms, the neurophysiological mechanism which triggers a cascade of changes in the peripheral and autonomic nervous systems and endocrine system, is the most widely accepted [9]. However, a single session of spinal mobilization or manipulation produces significant yet shortlived neurophysiological effects, typically lasting 5 min or less [17,18].…”

“…However, a single session of spinal mobilization or manipulation produces significant yet shortlived neurophysiological effects, typically lasting 5 min or less [17,18]. More recently, there is moderate emerging evidence supporting a modulation of biochemical mechanisms as well, suggesting that a mechanical stimuli provided by SM can trigger changes in analgesic and anti-inflammatory serum markers in asymptomatic individuals [9,19].…”

Die Wirkungen von Wirbelsäulenmanipulation auf das Immun- und Hormonsystem

“…Kovanur-Sampath et al [1] Narrative Übersichtsarbeiten geben einen umfassenden Überblick zu einem bestimmten Bereich [9]. Diese Art von Übersichtsarbeit kommt zur Anwendung, wenn ein schneller Überblick über den aktuellen Forschungsstand in einem bestimmten Bereich notwendig ist.…”