Changes in Bacterial Resistance Patterns of Pediatric Urinary Tract Infections and Rationale for Empirical Antibiotic Therapy

Gökçe, İbrahim; Çiçek, Neslihan; Güven, Serçin; Altuntaş, Ülger; Bıyıklı, Neşe; Yıldız, Nurdan; Alpay, Harika

doi:10.4274/balkanmedj.2015.1809

Cited by 16 publications

(13 citation statements)

References 11 publications

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“…In the present study, the proportion of UTI was significantly higher in females (73%) than in males (27%). Our results were consistent with other studies that showed that UTI was more frequent in females [ 5 , 13 , 15 , 16 ]. High frequency of UTI in females can be due to anatomical differences such as shortness of urethra and close space between the anus and urethral orifice [ 17 , 18 ].…”

Section: Discussionsupporting

confidence: 94%

A decade of trends in the distribution and antimicrobial susceptibility of prevalent uropathogens among pediatric patients from Tehran, Iran during 2005–2016

Nateghian

Karaji

Zamani

2021

Asian Journal of Urology

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Objectives To determine changes in the distribution of uropathogens and their antimicrobial resistance in pediatric patients in a children's hospital from 2005 to 2016. Methods A cross-sectional analysis of uropathogens and their antimicrobial resistance within inpatient children was performed over the 11-year period, 2005 to 2016, in Ali Asghar children's hospital. The rate of antibiotic resistance among patients was evaluated according to demographic data including age, sex, urinary tract abnormities and history of antibiotic consumption. Results In total, 958 female and 349 male positive cultures were analyzed. Escherichia coli ( E. coli ) (77.6%) was the most common causative agent of urinary tract infection (UTI) in children and Klebsiella pneumoniae (10.4%), Pseudomonas aeruginosa (2.4%), and Enterococcus spp (2.4%) were less frequent isolated bacteria. The resistance rates of E. coli isolates were increased against amikacin, ceftriaxone, ceftazidime, ciprofloxacin, cotrimoxazole and imipenem from 2005 to 2010. However, we observed a decreasing trend for some of antibiotics including amikacin, gentamicin, imipenem, ceftazidime and cotrimoxazole during 2014–2016. The rate of antibiotic resistance was greater in boys than in girls against many antibiotics. The rate of resistance to amikacin, gentamicin, nitrofurantoin and cotrimoxazole in patients aged <1 year was higher than other age groups ( p <0.001). A higher antibiotic resistance rate was observed in patients with anatomical abnormality and those who have had a history of antibiotic consumption. Conclusion The study indicated the significant decrease in E. coli antibiotic resistance in the last 3 years. An effective empirical treatment regime should be based on local epidemiology and antimicrobial susceptibility testing.

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Section: Discussionsupporting

confidence: 94%

A decade of trends in the distribution and antimicrobial susceptibility of prevalent uropathogens among pediatric patients from Tehran, Iran during 2005–2016

Nateghian

Karaji

Zamani

2021

Asian Journal of Urology

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“…agalactiae was very sensitive to ceftriaxone. Our findings of high resistance rate to cephalosporines are significantly and agreeing with other studies in Iran (Ranjbar et al, 2009), and Turkey (Gökçe et al, 2017).…”

Section: Zanco Journal Of Pure and Applied Sciences 2019supporting

confidence: 93%

Antibiotic Resistance of Bacteria isolated in Urinary Tract Infections in Erbil City.

2019

ZJPAS

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Urinary tract infections (UTIs) are the most unnoticed diseases worldwide. The resistant bacteria in UTI against commonly prescribed antimicrobials is coming forward with a daily demand for the management of antimicrobial treatment in health services. To estimate the resistance evolution of bacteria causing urinary tract infections to commonly used antimicrobials and to evaluate the options for treatment of UTIs. A total of 43 uropathogens of Gram-negative and Gram-positive bacteria were identified by using highly automated VITEK®2 System in Rizgare hospital; Erbil, Iraq; From January 2016 to December 2017. Four hundred eighty-two Urine samples from patients were cultured on appropriate bacteriological media and antibiotic sensitivity was determined by using disc diffusion method. From 482 urine specimens 80 % had positive results for bacterial cultures further more Among the 482 uropathogens, 184 samples tested for Extended-spectrum beta-lactamase (ESBL) which 94% was found to produce ESBLs. E-coli was the most common agent of UTIs (41.3 %) followed by Staphylococcus spp. (19.9%); Klebsiella spp. (11.6 %); Streptococcus spp. (7.3%); Pseudomonas aeruginosa (5%), Sphingomonas paucimobilis (4.1%); Enterococcus spp. (3.1%); Proteus mirabilis (2.9 %); other (4.8%). The disk diffusion assay proved that high degree of resistance among pathogens was to ampicillin; aztreonam; cephalothin; clindamycin; tetracycline. The lowest resistance was to amikacin; ciprofloxacin; imipenem and nitrofurantoin. Supervision for using favorable antibiotics and reducing the infection are very important.

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“…Whereas in a research done in Istanbul, 61% of patients were female (1.5 girls: 1 boy) and the average age was 3 years and 9 months. (15) Women made up the majority of respondents in a research carried out in Kashmir. Our research found that 76.4% of participants responded well to Fosfomycin, whereas 54.5 % responded favourably to ciprofloxacin.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Acute, Uncomplicated Urinary Tract Infections in Children: A Comparison of a Single Oral Dosage of Fosfomycin Against a Seven-Day Course of Ciprofloxacin

Tariq¹,

Shaikh²,

Tariq³

et al. 2022

PJMHS

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Objective : Urinary tract infection is one of the commonest infections in the pediatric age group. The emergence of resistance to various antibiotics has posed many difficulties in treating such patients. This study has been done to compare the efficacy of fosfomycin & ciprofloxacin in pediatric Urinary tract infection (UTI). Study Design: Randomized Control study Place and Duration: Akhtar Saeed Medical College/ Farooq Hospital. July, 2021 to Dec, 2021 Methodology: This randomized controlled clinical trial is done at the Department of Pediatrics, Akhtar Saeed Medical College/ Farooq Hospital. One hundred and thirty individuals who met the criteria for UTI were recruited. The patients were split into two groups at random. Patients in Group A received 15–20mg/kg of oral Ciprofloxacin twice daily (BD) for 7 days, whereas those in Group B received 150–300mg/kg of oral fosfomycin all at once. Results: One-hundred and ten patients included in this trial. In group A mean age of the paties was 6.4±2.8 years and in group B patients had mean age 7.7±3.0 years. There were 35 males (63.6%) and 20 females (36.4%) in group A and in group B 33 males (60%) and 22 females (40%). As per effectiveness we found that fosfomycin was effective in 42 patients (76.4%) and ciprofloxacin was efficacious in 30 patients (54.5%) with p-value 0.016. Conclusion: When comparing the treatment of children with acute uncomplicated urinary tract infections, the results showed that a single oral dosage of fosfomycin was substantially more effective than ciprofloxacin. Keywords: Antibiotics, Resistance, uropathogens, paediatrics, UTI, gram-negative,

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Changes in Bacterial Resistance Patterns of Pediatric Urinary Tract Infections and Rationale for Empirical Antibiotic Therapy

Cited by 16 publications

References 11 publications

A decade of trends in the distribution and antimicrobial susceptibility of prevalent uropathogens among pediatric patients from Tehran, Iran during 2005–2016

A decade of trends in the distribution and antimicrobial susceptibility of prevalent uropathogens among pediatric patients from Tehran, Iran during 2005–2016

Antibiotic Resistance of Bacteria isolated in Urinary Tract Infections in Erbil City.

Treatment of Acute, Uncomplicated Urinary Tract Infections in Children: A Comparison of a Single Oral Dosage of Fosfomycin Against a Seven-Day Course of Ciprofloxacin

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