Changes in bacterial isolates from burn wounds and their antibiograms: A 20-year study (1986–2005)

Guggenheim, Merlin; Zbinden, Reinhard; Handschin, Alexander E.; Gohritz, Andreas; Altintas, M.A.; Giovanoli, Pietro

doi:10.1016/j.burns.2008.09.004

Cited by 121 publications

(62 citation statements)

References 18 publications

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“…The high level of clindamycin resistance may be associated with inconsistent use of this antibiotic in clinical practice and community and also constitutive and inducible resistance. The rate of resistance to rifampicin was higher in our study (31.2%) compared to those reported in other studies from Germany (2%) (29) and Iran (5%) (24). In contrast to the results of the present study, high level of resistance to rifampicin was reported from Iraqi Kurdistan (57%) (21).…”

Section: Discussioncontrasting

confidence: 95%

Distribution of SCCmec Types in Methicillin-Resistant Staphylococcus aureus Isolated from Burn Patients

Afshari

Sepahi

Goudarzi

et al. 2017

Arch Clin Infect Dis

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Background: Methicillin resistance Staphylococcus aureus (MRSA) isolates have been recognized as one of the most important causes of infection in burn patients that have recently shown a frequent and rapid development of antibiotic resistance. Objectives: The present study described the distribution of different SCCmec types and antibiotic resistance pattern among MRSA strains isolated from burn patients in a referral burn center in Tehran, Iran. Methods: During a 12-month study, 189 MRSA isolates were obtained from burn patients. Standard culture and biochemical tests were used for identification of MRSA isolates. The antibiotic susceptibility testing was performed using disc diffusion method and the presence of mecA, nucA, pvl, and tst encoding genes was determined using PCR method. In addition, the different SCCmec types were determined using multiplex PCR. Results: All the MRSA isolates were observed to be resistant to amoxicillin and penicillin and sensitive to linezolid, teicoplanin, and vancomycin. The rates of resistance to other antibiotics varied from 86.2% for amikacin to 17.5% for quinupristin-dalfopristin. MDR was observed in all the isolates. Six different antimicrobial resistance patterns were observed among our isolates. Based on the multiplex PCR assay, the two different SCCmec types were detected as 71.4% type III and 28.6% type IV. In total, 8.5% of isolates harbored pvl toxin encoding gene all of which belonging to SCCmec type IV. Furthermore, 33 isolates (17.5%) harbored tst encoding gene. Conclusions:The results showed low diversity of SCCmec type among circulating MRSA in the burn center with relatively high prevalence of SCCmec III. These findings support the need for more studies to elucidate distribution of different SCCmec types among MRSA isolated from burn patients.

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Section: Discussioncontrasting

confidence: 95%

Distribution of SCCmec Types in Methicillin-Resistant Staphylococcus aureus Isolated from Burn Patients

Afshari

Sepahi

Goudarzi

et al. 2017

Arch Clin Infect Dis

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“…In the present study, S. aureus was among the most common pathogens isolated from SSTIs infections. This result is consistent with the results of other studies [24][25][26]. The prevalence rate of MRSA is different in various regions within a burn center.…”

Section: Discussionsupporting

confidence: 93%

Biofilm formation and antimicrobial resistance in methicillin-resistant Staphylococcus aureus isolated from burn patients, Iran

Moghadam

Pourmand

Aminharati

2014

J Infect Dev Ctries

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Introduction: Burns are the most serious forms of trauma and a major cause of mortality worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common pathogens of burn wound infections; treatment has faced serious problems due to antibiotic resistance in these strains. Biofilm formation, which increases antibiotic resistance capabilities and is considered to be a virulence factor, also causes treatment failure and recurrent staphylococcal infections in burn patients. Methodology: A total of 135 pus/wound swabs were collected; S. aureus was identified by confirmatory tests. The icaA/D and mecA genes were detected in DNA extracts by polymerase chain reaction assay separately. To determine the prevalence of biofilm formation, a modified Congo red agar and the microtiter plate method were used. Investigation of antibiotic resistance was performed using the disk diffusion method. Results: S. aureus (48.87%) was identified in 65 (48.87%) samples, of which 40 (61.53%) were confirmed to be MRSA. Among MRSA and methicillin-sensitive S. aureus (MSSA) isolates, 97.5% and 60% produced biofilm, respectively. Resistance of MRSA isolates to amikacin, ceftriaxone, ciprofloxacin, erythromycin, gentamicin, mupirocin, rifampin, tetracycline, and tobramycin was 64.1%, 76.92%, 51.28%, 87.18%, 71.8%, 10.26%, 5.13%, 89.74%, and 61.54%, respectively. All MRSA and MSSA isolates were susceptible to fusidic acid, linezolid, teicoplanin, tigecycline, and vancomycin. Conclusions: The high prevalence of biofilm-producing, drug-resistant S. aureus isolates in our study suggests that epidemiological studies on the characteristics of common strains found in burn centers and a definition of their antibiotic resistance pattern would be helpful for therapeutic decisions.

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“…More recently, a 20-years review of the changes in bacterial isolates from burn wounds and their antibiograms in Europe showed that MRSA remain the most frequent gram-positive pathogen [20]. But this finding is disagree with the study conducted by Habibullah, S. which showed that the most common pathogens were Non MRSA (S. aureus) [16].…”

Section: Bacteriological Infectionsmentioning

confidence: 96%

Bacteriological Profile and Antibacterial Sensitivity Patterns of Isolates among Burn Patients in Sulaimani City

Rashid

Babakir‐Mina

Abdilkarim

et al. 2017

KJAR

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Changes in bacterial isolates from burn wounds and their antibiograms: A 20-year study (1986–2005)

Cited by 121 publications

References 18 publications

Distribution of SCCmec Types in Methicillin-Resistant Staphylococcus aureus Isolated from Burn Patients

Distribution of SCCmec Types in Methicillin-Resistant Staphylococcus aureus Isolated from Burn Patients

Biofilm formation and antimicrobial resistance in methicillin-resistant Staphylococcus aureus isolated from burn patients, Iran

Bacteriological Profile and Antibacterial Sensitivity Patterns of Isolates among Burn Patients in Sulaimani City

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