Changes in arterial blood pressure after single oral administration of milk‐casein‐derived peptides in spontaneously hypertensive rats

Miguel, Marta; Ruiz, José Ángel Gómez; Recio, Isidra; Aleixandre, Amaya

doi:10.1002/mnfr.200900448

Cited by 67 publications

(41 citation statements)

References 35 publications

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“…On the contrary, peptides with ACE-inhibitor activity detected in Parmesan after 6 months of ripening were not detected after 15 months of ripening (Addeo et al, 1992). Similarly, Gomez-Ruiz et al (2007) detected five peptides (DKIHPF, VRYL, LPQNILP, VPSERYL, KKYNVPQL) with ACE-inhibitor activity in Manchego cheese, which was confirmed on experimental rats (Miguel et al, 2010). Their concentration varied depending on the production process and ripening duration.…”

Section: Antihypertensive Peptidesmentioning

confidence: 90%

White cheeses as a potential source of bioactive peptides

et al. 2017

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In addition to the nutritional value, cheese and other fermented milk-based products are a good source of biologically active proteins and peptides. Bioactive peptides in cheese are mainly formed during cheese production, especially during ripening, which is one of the most important stages in cheese production. Since the ripening process differ significantly depending on the cheese type, it can be assumed that their bioactivity is also substantially different. White brined cheeses are specific for the region of South-Eastern Europe. They are characterized by relatively intensive proteolysis and as such may be of interest as products with favorable functional characteristics. Yet, their functionality is still insufficiently characterized. This paper presents an overview of the current knowledge on white brined cheese's bioactive peptides.

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Section: Antihypertensive Peptidesmentioning

confidence: 90%

White cheeses as a potential source of bioactive peptides

et al. 2017

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“…Studies such as these suggest that such opioid peptides may lower blood pressure through receptors expressed in the GIT, implying that no absorption is required. Miguel et al (196) noted that mechanisms other than ACE inhibition have been reported to explain the antihypertensive effect of various peptide sequences, for example, vasodilation (197 -199) and antioxidant activity (200 -202) . Interestingly a local RAS has been reported to be present in the small intestine, with the key components being expressed at the gene and protein levels of the jejunal and ileal enterocytes (203) .…”

Section: Opioid-acting Peptidesmentioning

confidence: 98%

Are intact peptides absorbed from the healthy gut in the adult human?

2014

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For over 100 years it was believed that dietary protein must be completely hydrolysed before its constituent amino acids could be absorbed via specific amino acid transport systems. It is now known that the uptake of di- and tripeptides into the enterocyte is considerable, being transported across the intestinal endothelium by the PepT1 H+/peptide co-transporter. There is also evidence that some di- and tripeptides may survive cytosolic hydrolysis and be transported intact across the basolateral membrane. However, other than antigen sampling, the transport of larger intact macromolecules across the intestinal endothelium of the healthy adult human remains a controversial issue as there is little unequivocal in vivo evidence to support this postulation. The aim of the present review was to critically evaluate the scientific evidence that peptides/proteins are absorbed by healthy intestinal epithelia and pass intact into the hepatic portal system. The question of the absorption of oliogopeptides is paramount to the emerging science of food-derived bioactive peptides, their mode of action and physiological effects. Overall, we conclude that there is little unequivocal evidence that dietary bioactive peptides, other than di- and tripeptides, can cross the gut wall intact and enter the hepatic portal system in physiologically relevant concentrations.

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“…WPH and fractions and peptide sequences were orally administered in 1 ml of autoclaved water to SHR by gastric intubation. The doses administered were chosen based on previous experiments from our group and are in accordance with other similar studies [15,16].…”

Section: Experimental Groupsmentioning

confidence: 98%