Changes in aquaporins expression due to acute water restriction in naturally aging mice

Kim, So-Jeong; Baek, Kyung‐Wan; Jung, Youn‐Kwan; Kim, Ji‐Seok; Kim, Bo-Gyu; Yu, Hak Sun; Park, Jin Sung; Yoo, Jun‐Il

doi:10.1007/s13105-022-00921-5

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Fluid loss is a common occurrence in various tissues during the aging process, and it is closely associated with the function of aquaporins ( Kim et al, 2023 ). YunFeng Rui et al discovered that aquaporin expression decreased during tendon aging and interfering with its expression can alleviate age-related decline in cell function.…”

Section: Discussionmentioning

confidence: 99%

Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study

Zhang,

Shang,

et al. 2024

Front. Bioeng. Biotechnol.

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Purpose: This study was aimed to examine the global research status and current research hotspots in the field of tendon stem cells.Methods: Bibliometric methods were employed to retrieve relevant data from the Web of Science Core Collection (WOSCC) database. Additionally, Citespace, Vosviewer, SCImago, and Graphad Prism were utilized to analyze the publication status in this field, identify the current research hotspots, and present a mini-review.Results: The most active countries in this field were China and the United States. Notable authors contributing significantly to this research included Lui Pauline Po Yee, Tang Kanglai, Zhang Jianying, Yin Zi, and Chen Xiao, predominantly affiliated with institutions such as the Hong Kong Hospital Authority, Third Military Medical University, University of Pittsburgh, and Zhejiang University. The most commonly published journals in this field were Stem Cells International, Journal of Orthopedic Research, and Stem Cell Research and Therapy. Moreover, the current research hotspots primarily revolved around scaffolds, molecular mechanisms, and inflammation regulation.Conclusion: Tendon stem cells hold significant potential as seed cells for tendon tissue engineering and offer promising avenues for further research Scaffolds, molecular mechanisms and inflammation regulation are currently research hotspots in this field.

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Section: Discussionmentioning

confidence: 99%

Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study

Zhang,

Shang,

et al. 2024

Front. Bioeng. Biotechnol.

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Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina

Carrero,

Antequera,

Alcalde

et al. 2023

IJMS

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Alzheimer’s disease (AD), the most prevalent form of dementia, is a neurodegenerative disorder characterized by different pathological symptomatology, including disrupted circadian rhythm. The regulation of circadian rhythm depends on the light information that is projected from the retina to the suprachiasmatic nucleus in the hypothalamus. Studies of AD patients and AD transgenic mice have revealed AD retinal pathology, including amyloid-β (Aβ) accumulation that can directly interfere with the regulation of the circadian cycle. Although the cause of AD pathology is poorly understood, one of the main risk factors for AD is female gender. Here, we found that female APP/PS1 mice at 6- and 12-months old display severe circadian rhythm disturbances and retinal pathological hallmarks, including Aβ deposits in retinal layers. Since brain Aβ transport is facilitated by aquaporin (AQP)4, the expression of AQPs were also explored in APP/PS1 retina to investigate a potential correlation between retinal Aβ deposits and AQPs expression. Important reductions in AQP1, AQP4, and AQP5 were detected in the retinal tissue of these transgenic mice, mainly at 6-months of age. Taken together, our findings suggest that abnormal transport of Aβ, mediated by impaired AQPs expression, contributes to the retinal degeneration in the early stages of AD.

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Changes in aquaporins expression due to acute water restriction in naturally aging mice

Cited by 2 publications

References 30 publications

Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study

Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study

Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina

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