CHANGES IN APNEA AND AUTORESUSCITATION IN PIGLETS AFTER INTRAVENOUS AND INTRATECHAL INTERLEUKIN- 1ß INJECTION

Stoltenberg, Lauritz; Sundar, Tom; Almaas, Runar; Saugstad, Ola Didrik

doi:10.1203/00006450-199402000-00078

Cited by 2 publications

(2 citation statements)

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“…IL-1 [j injected intravenously or intratechaly in piglets has been shown to increase the reflex apnoea response (25). We have only, in accordance with ethical limitations, measured IL-lp and IL-6 in pharyngeal secretions.…”

Section: Rsv Interleukin Concentration and Apnoeamentioning

confidence: 99%

Reflex apnoea response and inflammatory mediators in infants with respiratory tract infection*

Lindgren

Grøgaard

1996

Acta Paediatrica

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The reflex apnoea response to water stimulation was evaluated in infants with respiratory syncytial virus (RSV) infection and compared to the response in non-infected infants who had sustained an apparent life-threatening event (ALTE) or were siblings of infants who had died of sudden infant death syndrome (SIDS). RSV-infected infants had a significantly (p < 0.05) reinforced reflex apnoea response compared with non-infected infants. There was a significant negative correlation between the concentration of interleukin 1 beta (IL-I beta) in pharyngeal secretions and the duration of apnoea (p < 0.01). Increased clinical severity was, however, associated with high (> 5.000 pg ml-1) concentrations of IL-1 beta. There was no correlation between apnoea and interleukin 6. These findings may be relevant for the understanding of why apnoea may be the presenting symptom of RSV infection, and offer an explanation of why a proportion of SIDS cases has a history of mild respiratory tract symptoms prior to death.

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Section: Rsv Interleukin Concentration and Apnoeamentioning

confidence: 99%

Reflex apnoea response and inflammatory mediators in infants with respiratory tract infection*

Lindgren

Grøgaard

1996

Acta Paediatrica

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“…These include bacterial toxaemia [2], hyperthermia [3] and synergistic interactions between bacterial toxins, viral infections and exposure to cigarette smoke [4]. Acute-phase response cytokines such as IL-1 and IL-6, which induce sleep, prolong apnoeas and impair autoresuscitation [5][6][7], have also been implicated in SIDS [8].…”

Section: Introductionmentioning

confidence: 99%

Endotoxin Effects on Markers of Autonomic Nervous System Function in the Piglet: Implications for SIDS

Voss¹,

Bolton²,

Galland³

et al. 2004

Neonatology

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The hypothesis was tested in 30 newborn piglets that the effects of a low dose of endotoxin (1 µg i.v. bolus; Salmonella abortus equi) would impair autonomic nervous system function. Two tests of autonomic function were performed following external warming (pre-endotoxin) and during endotoxin-generated thermogenesis: (1) analysis of heart rate variability in the time and frequency domains and (2) baroreflex sensitivity measured following intravenous injection of the vasoactive drugs nitroprusside and phenylephrine. Beat-to-beat heart rate variability (SDΔRR) fell by 2.2 ms from 7.0 ms before fever (p < 0.05). Low-frequency spectral power fell by 2.4 ms² from 4.1 ms² before fever (p < 0.05). The sensitivity of the baroreflex to changes in blood pressure induced by the vasoactive drugs decreased during fever by 0.72 ms/mm Hg for the nitroprusside test (p < 0.0005) and by 0.31 ms/mm Hg for the phenylephrine test (p < 0.005). These results indicate that in the piglet the balance of autonomic tone is altered and autonomic responsiveness reduced during the thermogenic phase of a fever. These findings are consistent with known risk factors for sudden infant death syndrome.

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CHANGES IN APNEA AND AUTORESUSCITATION IN PIGLETS AFTER INTRAVENOUS AND INTRATECHAL INTERLEUKIN- 1ß INJECTION

Cited by 2 publications

References 0 publications

Reflex apnoea response and inflammatory mediators in infants with respiratory tract infection*

Reflex apnoea response and inflammatory mediators in infants with respiratory tract infection*

Endotoxin Effects on Markers of Autonomic Nervous System Function in the Piglet: Implications for SIDS

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