Changes in aggressive behavior, thermoregulation, and endocrine responses in BALB/cLac and C57Bl/6J mice under cold exposure

Мошкин, М. П.; Потапов, М. А.; Frolova, O.F.; Evsikov, V. I.

doi:10.1016/0031-9384(93)90150-e

Cited by 13 publications

(3 citation statements)

References 10 publications

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“…This higher sMV suggests that C57BL/6 may have a higher basal metabolism than BALB/c, at least at an ambient temperature of 22°C. There are a number of arguments to back up this explanation: with the same age and sex, C57BL/6 is smaller and lighter, the rectal temperature of C57BL/6 is higher than that of BALB/c (44), the level of activity of C57BL/6 is higher than that of BALB/c (8,38), the thyroid secretion rate is higher in C57BL/6 (3), and the basal oxygen consumption is higher in C57BL/6 (33). Also, a higher sMV in C57BL/6 like this could be due to differences in the oxygen transport chain.…”

Section: Discussionmentioning

confidence: 99%

Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice

Flandre¹,

Leroy

Desmecht³

2003

Journal of Applied Physiology

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Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically, however, this technique combines the advantages of single-chamber plethysmography with a quantitative assessment of flow and/or volume and a calculated resistance, the interpretation of which in terms of bronchoconstriction is not disputed. Here we show that, when appropriately preconditioned, mice are able to gradually grow accustomed to the apparatus and display extremely stable nasal and thoracoabdominal flow tracings. Overall, strain, sex, and somatic growth had a significant effect on pulmonary function values. The changes in specific airway resistance (sRaw) and enhanced pause (Penh) values were never in the same direction, indicating that they measure different things. The respiratory frequency was far higher in C57BL/6 compared with BALB/c mice. Peak flows, minute volume, specific tidal and minute volumes, and sRaw were also higher, but Penh was smaller. Males breathed at a higher frequency than females, leading to a higher minute volume. Nevertheless, the specific volumes were considerably higher among females. Penh was lower in males, whereas sRaw was identical in both sexes. Changes associated with somatic growth were rapid and important between 5 and 9 wk, then slowed down between 9 and 12-13 wk and became almost imperceptible after.

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Section: Discussionmentioning

confidence: 99%

Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice

Flandre¹,

Leroy

Desmecht³

2003

Journal of Applied Physiology

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“…Huddling may function in thermoregulation [3,28]. However, the thermoregulatory capacities of C57BL/6J are in line with those of other strains such as A/Js and BALB/cLac [18,48,60], suggesting that it may be difficult to ascribe their high tendency to huddle only to thermoregulatory needs. In addition, we noted that huddling mice, particularly males in the mixed-sex groups, spent considerable time (between 10 and 20% of huddle time during the active period) in allogrooming.…”

Section: Specific Social Behaviorsmentioning

confidence: 96%

Colony formation of C57BL/6J mice in visible burrow system: Identification of eusocial behaviors in a background strain for genetic animal models of autism

Arakawa

Blanchard

2007

Behavioural Brain Research

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Deficits in social interaction are primary characteristics of autism, which has strong genetic components. Genetically-manipulated mouse models may provide a useful research tool to advance the investigation of genes associated with autism. To identify these genes using mouse models, behavioral assays for social relationships in the background strains must be developed. The present study examined colony formation in groups of one male and three female mice (Experiment 1) and, groups of three male mice (Experiment 2) of the C57BL/6J strain in a seminatural visible burrow system. For adult mixed-sex colonies, four-hour observations during both the dark and light cycles for 15 days demonstrated day-dependent increases in huddling together in the chamber accompanied by decreased frequencies of active social behaviors. Sequential analyses of social interactions indicated that approaches to the back of the approached animal typically elicited flight, while approaches to the front of the approached animal failed to do so. This was seen for female to female, and for female to male approaches, as well as male to female approaches, strongly counter indicating a view that rear approach/flight specifically reflects female responsivirity to unwanted male sexual approach. For adult male colonies, similar protocols found that these social behaviors were similar to those of adult mixed-sex colonies. These findings suggest two potentially useful measures of eusocial behavior in mice, of possible value for genetic mouse models of autism; that is, huddling together and approaches to the front but not the back, of conspecifics.

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“…In animal models, testosterone has been shown to also seasonally affect thermoregulation, within interspecies competition, under stress related conditions, and in terms of overall activity [ 21 , 22 ]. In the Afrotropical pouched mouse ( Saccostomus campestris; rodentia ), testosterone inhibited torpor in males, increasing their overall basal temperature 4°C higher than females [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of castration on physiological responses to exertional heat stroke in mice

Garcia

Robinson²,

Gambino³

et al. 2022

PLoS ONE

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Introduction The capability of male mice to exercise in hot environments without succumbing to exertional heat stroke (EHS) is markedly blunted compared to females. Epidemiological evidence in humans and other mammals also suggests some degree of greater vulnerability to heat stroke in males compared to females. The origins of these differences are unknown, but testosterone has previously been shown to induce faster elevations in core temperature during acute, passive heat exposure. In this study, we tested the hypothesis that loss of testosterone and related sex hormones through castration would improve the performance and heat tolerance of male mice during EHS exposure. Methods Twenty-four male mice were randomly divided into 3 groups, untreated EHS mice (SHAM-EHS), castrated EHS mice (CAS+EHS) and naïve exercise controls (NAIVE). Exercise performance and physiological responses in the heat were monitored during EHS and early recovery. Two weeks later, blood and tissues were collected and analyzed for biomarkers of cardiac damage and testosterone. Results Core temperature in CAS+EHS rose faster to 39.5°C in the early stages of the EHS trial (P<0.0001). However, both EHS groups ran similar distances, exhibited similar peak core temperatures and achieved similar exercise times in the heat, prior to symptom limitation (unconsciousness). CAS+EHS mice had ~10.5% lower body mass at the time of EHS, but this provided no apparent advantage in performance. There was no evidence of myocardial damage in any group, and testosterone levels were undetectable in CAS+EHS after gonadectomy. Conclusions The results of these experiments exclude the hypothesis that reduced performance of male mice during EHS trials is due to the effects of male sex hormones or intact gonads. However, the results are consistent with a role of male sex hormones or intact gonads in suppressing the early and rapid rise in core temperature during the early stages of exercise in the heat.

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Changes in aggressive behavior, thermoregulation, and endocrine responses in BALB/cLac and C57Bl/6J mice under cold exposure

Cited by 13 publications

References 10 publications

Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice

Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice

Colony formation of C57BL/6J mice in visible burrow system: Identification of eusocial behaviors in a background strain for genetic animal models of autism

The impact of castration on physiological responses to exertional heat stroke in mice

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