Changes in afferent impulse activity of small intestine mesenteric nerves in response to antigen challenge

Nozdrachev, A. D.; Akoev, G. N.; Филиппова, Л В; Sherman, N. O.; Lioudyno, Maria; Makarov, F. N.

doi:10.1016/s0306-4522(99)00377-2

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…In addition to increased concentration of these cells, mucosal mast cells in patients with both diarrhea-predominant and constipation-predominant IBS are in close vicinity to nerve varicosities supplying the mucosa [ 18 , 31 ]. Based on previous experimental data, mast-cell activation has been reported to increase enteric neuron excitability [ 32 , 33 ] and enhance potential fi ring of extrinsic sensory neurons [ 34 ], accounting for gut sensorimotor dysfunction [ 35 ]. Recently, we showed ultrastructural features of increased mast-cell activation in the colonic mucosa of IBS patients and demonstrated that the activated mast cells released signifi cant amounts of various mediators, including tryptase and histamine [ 18 ].…”

Section: Morpho-functional Correlates Of Infl Ammation In Ibsmentioning

confidence: 95%

“…It is known that mast-cell tryptase, acting through protease-activated receptors (PARs) [ 36 ], induces activation of PAR-2 expressed by enteric nerves and visceral afferents, thereby eliciting neuronal hyperexcitability [ 32 , 33 , 37 ]. In addition to tryptase, histamine also can activate visceral sensory nerves [ 34 ] and enteric neurons [ 38 ] binding to different subtypes of histamine receptors, mainly histamine-1 and histamine-2 [ 38 ]. These data indicate that tryptase and histamine are candidate mediators for gut sensorimotor dysfunction in IBS and their pharmacologic targeting may open new perspectives in the treatment of this disease.…”

Section: Morpho-functional Correlates Of Infl Ammation In Ibsmentioning

confidence: 99%

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Is irritable bowel syndrome an inflammatory disorder?

Giorgio

Barbara²

2008

Curr Gastroenterol Rep

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Histopathologic data demonstrate low-grade mucosal inflammation in a subset of patients with irritable bowel syndrome (IBS). This inflammatory infiltrate is mainly represented by increased numbers of T lymphocytes and mast cells lying in the lamina propria. The close apposition of immunocytes to gut nerves supplying the mucosa provides a basis for neuroimmune cross-talk, which may explain gut sensorimotor dysfunction and related symptoms in patients with IBS. A previous gastroenteritis (due to Campylobacter jejuni, Salmonella, Shigella, Escherichia coli, and, likely, viruses) is now an established etiologic factor for IBS (hence, postinfectious IBS). Other putative causes, such as undiagnosed food allergies, genetic abnormalities, stress, or bile acid malabsorption, may also promote and maintain a low-grade mucosal inflammation in IBS. The identification of mucosal inflammation in IBS has pathophysiologic implications and paves the way for novel therapeutic options.

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Section: Morpho-functional Correlates Of Infl Ammation In Ibsmentioning

confidence: 95%

Section: Morpho-functional Correlates Of Infl Ammation In Ibsmentioning

confidence: 99%

Is irritable bowel syndrome an inflammatory disorder?

Giorgio

Barbara²

2008

Curr Gastroenterol Rep

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“…Increased mast cells have been detected in the colonic and ileal mucosa of IBS patients. 1,8,9 This increase is most marked in the diarrhea-predominant subgroup. 2,10 Rectal sensitivity is enhanced in diarrhea-predominant IBS patients with moderately increased mucosal mast cells.…”

Section: Introductionmentioning

confidence: 93%

“…Mucosal mast cells have also been implicated in the pathogenesis of inflammation. Increased mast cells have been detected in the colonic and ileal mucosa of IBS patients 1,8,9 . This increase is most marked in the diarrhea‐predominant subgroup 2,10 .…”

Section: Introductionmentioning

confidence: 97%

The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors

Lee¹,

Kim

et al. 2008

J of Gastro and Hepatol

146

113

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Background/Aims: Psychological factors and subtle histopathological changes have been implicated in irritable bowel syndrome (IBS). The aims of the present study were to investigate whether the numbers of enterochromaffin (EC) cells, mast cells, and lamina propria T lymphocytes are altered in IBS, and evaluate the relationship of such alterations with psychological factors. Methods: Forty-two consecutive IBS patients (M : F = 17:25, mean age 48 years) fulfilling the Rome III criteria and twelve asymptomatic healthy controls underwent rectal biopsy. Immunostaining was performed for EC cells, mast cells, and lamina propria T lymphocytes. Results: The IBS group included five post-infectious (PI) IBS and 37 non-PI IBS patients. Significantly more EC cells, mast cells and lamina propria T lymphocytes were observed in PI IBS patients. Mast cells significantly increased in non-PI IBS-D (diarrhea) patients, but not in non-PI IBS-C (constipation) and non-PI IBS-M (mixed) patients. Enterochromaffin cell numbers were not significantly altered in non-PI IBS patients. Anxiety and depression scores did not differ between IBS patients with and without abnormal increase in EC cell or mast cell counts, defined as more than the mean of controls + 2 standard deviations. Enterochromaffin cell, mast cell, or lamina propria T lymphocyte numbers were poorly correlated with anxiety and depression scores in the IBS group. Conclusions: Enterochromaffin cells, mast cells, and lamina propria T lymphocytes significantly increase in PI IBS, whereas only mast cells significantly increase in non-PI IBS-D. Such histopathological changes do not seem to be directly associated with psychological factors.

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“…Intensive studies of integrative activity of neuroendocrineimmune network showed that sensory terminals of afferent fi bers of the small intestine are involved in modulation of the responses to invasion of foreign antigens, being activated by mediators released from immune cells [1,2,5,7,8,11]. Normally, proper (intrinsic) neurons in the wall of the gastrointestinal tract do not directly contact to gut contents.…”

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confidence: 99%

Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons

et al. 2015

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Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level.

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Changes in afferent impulse activity of small intestine mesenteric nerves in response to antigen challenge

Cited by 17 publications

References 17 publications

Is irritable bowel syndrome an inflammatory disorder?

Is irritable bowel syndrome an inflammatory disorder?

The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors

Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons

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