Changes in adipose tissue gene expression and plasma levels of adipokines and acute-phase proteins in patients with critical illness

Jernås, Margareta; Olsson, Bob; Sjöholm, Kajsa; Sjögren, Anders; Rudemo, Mats; Nellgård, Bengt; Carlsson, Lena; Sjöström, C. David

doi:10.1016/j.metabol.2008.08.012

Cited by 45 publications

(38 citation statements)

References 36 publications

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“…In previous studies, the adiponectin secretion pattern during sepsis has not been thoroughly characterized. A similar pattern was also recently reported in a cohort of protracted critical illness of pulmonary origin [4] and in 8 patients recovering from subarachnoidal hemorrhage [27]. In contrast, in the study by Venkatesh et al [20], adiponectin levels did not change significantly in critically ill subjects; however, the study was limited to days 3 and 7 days of critical illness, so that the early and protracted phases were not assessed.…”

Section: Initial Levelssupporting

confidence: 74%

Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels

Vassiliadi

Tzanela

Κοτανίδου

et al. 2012

Journal of Critical Care

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Section: Initial Levelssupporting

confidence: 74%

Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels

Vassiliadi

Tzanela

Κοτανίδου

et al. 2012

Journal of Critical Care

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“…Because adipose tissue is considered to be the main source of circulating A-FABP, we believe that upregulation of A-FABP expression and/or increased secretion from the adipose tissue contributes to elevated levels in patients with critical illness. It is supported by Jernas' study, which demonstrates that adipose tissue gene expression changes in patients with critical illness [25]. Another study by Han also showed that intermittent hypoxia induced A-FABP expression in endothelial cells [26].…”

Section: Discussionmentioning

confidence: 84%

Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality

Huang

Hsieh

et al. 2013

Crit Care

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IntroductionHyperglycemia and insulin resistance are commonplace in critical illness, especially in patients with sepsis. Recently, several hormones secreted by adipose tissue have been determined to be involved in overall insulin sensitivity in metabolic syndrome-related conditions, including adipocyte fatty-acid binding protein (A-FABP). However, little is known about their roles in critical illness. On the other hand, there is evidence that several adipose tissue gene expressions change in critically ill patients.MethodsA total of 120 patients (72 with sepsis, 48 without sepsis) were studied prospectively on admission to a medical ICU and compared with 45 healthy volunteers as controls. Various laboratory parameters and metabolic and inflammatory profiles were assessed within 48 hours after admission. Clinical data were collected from medical records.ResultsCompared with healthy controls, serum A-FABP concentrations were higher in all critically ill patients, and there was a trend of higher A-FABP in patients with sepsis. In multivariate correlation analysis in all critically ill patients, the serum A-FABP concentrations were independently related to serum creatinine, fasting plasma glucose, total cholesterol, TNF-alpha, albumin, and the Acute Physiology and Chronic Health Evaluation II scores. In survival analysis, higher A-FABP levels (> 40 ng/ml) were associated with an unfavorable overall survival outcome, especially in sepsis patients.ConclusionsCritically ill patients have higher serum A-FABP concentrations. Moreover, A-FABP may potentially serve as a prognostic biomarker in critically ill patients with sepsis.

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“…Second, a separate analysis of mature adipocytes and stroma was not performed, and consequently, we cannot answer the question of whether the down-regulation of ZAG expression in adipose tissue is mainly due to mature adipocytes or to stroma-vascular fraction. Recently Jernås et al (31) suggested that ZAG could be included as a new acute-phase reactant released from adipose tissue. This finding is important when interpreting the results of studies in which samples obtained during a stressful surgical process have been used.…”

Section: Discussionmentioning

confidence: 99%

Lower Zinc-α2-Glycoprotein Production by Adipose Tissue and Liver in Obese Patients Unrelated to Insulin Resistance

Selva

Lecube

Hernández

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

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Changes in adipose tissue gene expression and plasma levels of adipokines and acute-phase proteins in patients with critical illness

Cited by 45 publications

References 36 publications

Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels

Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels

Serum adipocyte fatty acid-binding protein levels in patients with critical illness are associated with insulin resistance and predict mortality

Lower Zinc-α2-Glycoprotein Production by Adipose Tissue and Liver in Obese Patients Unrelated to Insulin Resistance

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