Changes in activities of zinc-dependent enzymes in zinc-deficient tissues of rats

As, Prasad; Oberleas, Donald

doi:10.1152/jappl.1971.31.6.842

Cited by 79 publications

(19 citation statements)

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“…The atrophy of thymuses in the ZD rats was conspicuous compared with the ZA rats in both experiments I and II. Rat thymic atrophy by zinc deficiency has been also found in the previous studies [13,17]. Thymic atrophy inhibits maturation of the T cell and/or B cell in acquired immunity and macrophages in innate immunity are considered to be reduced in zinc-deficient animals [20].…”

supporting

confidence: 59%

Influence of Zinc Deficiency to the Rats Infected with Babesia rodhaini

Hamaguchi

Ike

Yamamoto

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Zinc deficiency induces a wide range of disorders including immunodeficiency. It is known that microbial infections occur with a high frequency in the zinc-deficient hosts, but the study on the correlation between parasitic infection and zinc status in hosts is scarcely performed. We observed that the influence of zinc deficiency to the rats infected with Babesia rodhaini. Experiments of B. rodhaini infection were conducted using zinc-deficient (ZD; eat ad libitum or 10 g/day on the ZD diet), zinc-adequate (ZA; eat ad libitum on the ZA diet), and diet-restricted (DR; eat 7 g/day on the ZA diet) rats. The findings in this study suggested that the zinc deficiency had deleterious effects on the hemodynamics and mortality of the rats infected with B. rodhaini.

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supporting

confidence: 59%

Influence of Zinc Deficiency to the Rats Infected with Babesia rodhaini

Hamaguchi

Ike

Yamamoto

et al. 2009

The Journal of Veterinary Medical Science

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“…Zinc deficiency may also cause or contribute to a number of relatively non-specific conditions commonly observed in hemodialysis patients, including anorexia, dysgeusia, and impaired cognitive function (18,19). The biochemical changes, particularly increased plasma ammonia and ribonuclease activity, which have been reported in experimentally induced zinc deficiency in human beings and animals (20,21) have been reported in patients on hemodialysis with low serum zinc concentrations (22). Copper deficiency may be associated with anemia which may be megaloblastic or sideroblastic and leucopoenia (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Hemodialysis on Serum Copper and Zinc Levels in Renal Failure Patients

2013

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“…It has been known for many years that zinc deficiency in experimental animals results in atrophy of thymic and lymphoid tissue (30)(31)(32)(33). These changes are associated with a variety of functional abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Serum thymulin in human zinc deficiency.

Prasad¹,

Meftah²,

Abdallah³

et al. 1988

J. Clin. Invest.

307

209

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The activity of thymulin (a thymic hormone) is dependent on the presence of zinc in the molecule. We assayed serum thymulin activity in three models of mildly zinc-deficient (ZD) human subjects before and after zinc supplementation: (a) two human volunteers in whom a specific and mild zinc deficiency was induced by dietary means; (b) six mildly ZD adult sickle cell anemia (SCA) subjects; and (c) six mildly ZD adult non-SCA subjects. Their plasma zinc levels were normal and they showed no overt clinical manifestations of zinc deficiency. The diagnosis of mild zinc deficiency was based on the assay of zinc in lymphocytes, granulocytes, and platelets. Serum thymulin activity was decreased as a result of mild zinc deficiency and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter was a sensitive indicator of zinc deficiency in humans. An increase in T101-, sIg-cells, decrease in T4+/T8+ ratio, and decreased IL 2 activity were observed in the experimental human model during the zinc depletion phase, all of which were corrected after repletion with zinc. Similar changes in lymphocyte subpopulation, correctable with zinc supplementation, were also observed in mildly ZD SCA subjects. Inasmuch as thymulin is known to induce intra-and extrathymic T cell differentiation, our studies provide a possible mechanism for the role of zinc on T cell functions.

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Changes in activities of zinc-dependent enzymes in zinc-deficient tissues of rats

Cited by 79 publications

References 0 publications

Influence of Zinc Deficiency to the Rats Infected with Babesia rodhaini

Influence of Zinc Deficiency to the Rats Infected with Babesia rodhaini

Effect of Hemodialysis on Serum Copper and Zinc Levels in Renal Failure Patients

Serum thymulin in human zinc deficiency.

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