“…Different chemotherapy regimens have been tested in ARL patients (Gisselbrecht et al , 1993; Kaplan et al , 1997; Little et al , 2003; Costello et al , 2004; Sparano et al , 2004) but there is still disagreement regarding the optimal treatment, even in the post‐HAART era. Overall improvement was observed by some investigators (Besson et al , 2001; Gerard et al , 2002) but not others (Matthews et al , 2000; Noy, 2004). The four‐drug CHOP regimen (cyclophosphamide, adriamycin, vincristine and prednisone) seems to confer some benefit with regard to the duration of remission, and to improve the results of the standard treatments for HIV‐negative patients with high‐grade NHL (Fisher et al , 1993).…”