Changes in abdominal aortic aneurysm epidemiology

Lilja, Fredrik; Wanhainen, Anders; Mani, Kevin

doi:10.23736/s0021-9509.17.10064-9

Cited by 35 publications

(13 citation statements)

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“…Regarding age, our findings are compatible with other studies that also observed a predominance of surgical treatments in elderly men. 16 - 18 We noticed a decrease in the number of procedures over the years. The European literature has shown a decrease in the frequency of emergency aneurysm repairs, with an increase in elective repairs, 17 in addition to a lower prevalence of aortic aneurysms over the decades.…”

Section: Discussionmentioning

confidence: 92%

Surgical repair of abdominal aortic aneurysms on the public health system in the largest city in Brazil: a descriptive analysis of in-hospital data on 2693 procedures over 10 years

et al. 2022

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Background From 1990 to 2015, mortality from aortic aneurysms increased 16.8% in Brazil. São Paulo is the largest city in Brazil and about 5 million people depend on the public health system there. Objectives To conduct an epidemiological analysis of abdominal aortic aneurysm surgeries in the city of São Paulo. Methods Infra-renal aortic aneurysm procedures performed over a decade (from 2008 to 2017) were studied using publicly-available platforms from the Unified Health System and DATASUS. Results 2693 procedures were analyzed; 66.73% were endovascular; 78.7% of patients were male; 70.7% were aged 65 years or more; 64.02% were elective hospital admissions. There were 288 in-hospital deaths (mortality: 10.69%). In-hospital mortality was lower for endovascular surgery than for open surgery; both for elective (4.13% versus 14.42%) and urgent (9.73% versus 27.94%) (p = 0.019) admissions. The highest volume hospital (n = 635) had the lowest in-hospital mortality (3.31%). USD 24,835,604.84 was paid; an average of $ 2,318.63 for elective open, $ 3,420.10 for emergency open, $ 12,157.35 for elective endovascular and $ 12,969.12 for urgent endovascular procedures. Endovascular procedure costs were statistically higher than the values paid for open surgeries (p <0.001). Conclusions Endovascular surgeries were performed twice as often as open surgeries; they had shorter hospital stays and lower mortality.

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Section: Discussionmentioning

confidence: 92%

Surgical repair of abdominal aortic aneurysms on the public health system in the largest city in Brazil: a descriptive analysis of in-hospital data on 2693 procedures over 10 years

et al. 2022

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“…During the past two decades a drop in newly discovered cases of AAA per year has been noticed, from the previous incidence of 30,1 -40 per 100.000 inhabitants to the currently estimated incidence of 13,2 -16 per 100.000 inhabitants. 2,3,4,5,6 From the moment the diagnosis of AAA is made, life expectancy is 11 years. 7 Aneurysm diameter above 5,5 cm is a threshold above which the operative treatment is recomended.…”

Section: Introductionmentioning

confidence: 99%

Assessment of timely detection of abdominal aortic aneurysm in Serbian population based on the data from Serbvasc registry of operated patients

Pešić¹,

Tanasković²,

Stepanovic³

et al. 2023

Medicinska istraživanja

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Introduction Screening of males over 65 years of age for abdominal aortic aneurysm (AAA) has been proved effective in some countries. The incidence of AAA in Serbian population has not been evaluated yet. The aim of the study was to assess the ratio between elective and urgently operated patients with AAA and to estimate hospital incidence of treated AAA based on the population of 100 000 inhabitants. Methods Data were obtained from Vascular surgery registry - Serbvasc which has been created by 17 institutions. Data containing demographic characteristics were obtained from the publication of the Statistical office of the Republic of Serbia. For statistical analysis, the methods of descriptive statistics were used and the values were expressed per 100 000 inhabitants. Results During the year 2021, 422 operations were performed in 7 hospitals due to asymptomatic, symptomatic and ruptured AAA in 323 (76,54%), 37(8,76%) and 62 (14,69%) patients, respectively. Hospital incidence of electively operated AAA is 8,06 cases per 100 000 inhabitants, whereas the incidence of operated ruptured AAA is 1,55 cases per 100 000 inhabitants. Overall hospital incidence of all operatively treated AAA is 10,53 cases per 100 000 inhabitants. Out of the total number of operated patients with AAA, 134 (31,75%) were younger than 65 years, while 22 (35%) out of 62 patients treated for rAAA, where younger than 65 years. Conclusion The incidence of operatively treated elective AAA is lower than the values reported in literature, while the rate of ruptured AAA is more than twice as high as the rate reported by recent papers. One third of treated patients were younger than 65 years. The most efficient strategy for reducing the number of urgently treated AAA is the implementation of screening for AAA in groups with higher risk.

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“…AAA is usually asymptomatic until rupture occurs. To evaluate the risk of AAA rupture early, ultrasound screening is recommended for people over 65 years of age in several countries [ 4 , 5 ]. However, no biomarker that can serve as a screening and surveillance tool for AAA in clinical practice has been made available to date.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis

Wang

Xie

et al. 2022

Biomolecules

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Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Additionally, “AAA without diabetes” (AAN) patients and “AAA complicated with type 2 diabetes mellitus” (AAM) patients had different cytokine expression patterns in their plasma, and nine plasma proteins were differentially expressed among the AAN, AAM, and HC subjects. Delta-like protein 1 (DLL1), receptor tyrosine-protein kinase erbB-3 (ERBB3), and dipeptidyl peptidase 4 (DPPIV) were significantly higher in AAM than in AAN. This study identified several promising plasma biomarkers of AAA. Their role as therapeutic targets for AAA warrants further investigation.

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Changes in abdominal aortic aneurysm epidemiology

Cited by 35 publications

References 0 publications

Surgical repair of abdominal aortic aneurysms on the public health system in the largest city in Brazil: a descriptive analysis of in-hospital data on 2693 procedures over 10 years

Surgical repair of abdominal aortic aneurysms on the public health system in the largest city in Brazil: a descriptive analysis of in-hospital data on 2693 procedures over 10 years

Assessment of timely detection of abdominal aortic aneurysm in Serbian population based on the data from Serbvasc registry of operated patients

Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis

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