Changes Associated with Long-Term Oral Administration of the Penem Antibiotic FCE 22891 to Rats and Monkeys with Particular Emphasis on the Urinary Tract and the Urine
Abstract:FCE 22891, a synthetic β-lactam antibiotic of the penem class, was administered by gavage to SpragueDawley rats and cynomolgus monkeys for 26 wk (with and without a 6-wk recovery). Rats received the test material at doses of 0, 200, 500, and 1,250 mg/kg/day, and monkeys were given doses of 0, 100, 200, 400, and 600 mg/kg/day. At the end of the 26-wk treatment period, approximately two-thirds of the animals (both species) were sacrificed, and the remaining animals were held without treatment for a further … Show more
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