Changed gene expression for candidate ageing genes in long-lived Bicyclus anynana butterflies

Pijpe, Jeroen; Pul, Nicolien; Duijn, Sara van; Brakefield, Paul M.; Zwaan, Bas J.

doi:10.1016/j.exger.2010.11.033

Cited by 18 publications

(18 citation statements)

References 49 publications

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“…Two previous studies that evaluated reference genes for qPCR in B . anynana , showed that Ef1α was a stable reference, including for quantifying genes in brain tissue, with a threshold expression stability M value below 0.5 [39, 40]. EcR exists in several isoforms (distinct only in their N-terminal domains) that are produced by alternative splicing of the EcR gene.…”

Section: Methodsmentioning

confidence: 99%

Steroid hormone signaling during development has a latent effect on adult male sexual behavior in the butterfly Bicyclus anynana

2017

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It is well established that steroid hormones regulate sexual behavior in vertebrates via organizational and activational effects. However, whether the organizational/activational paradigm applies more broadly to the sexual behavior of other animals such as insects is not well established. Here we describe the hormonal regulation of a sexual behavior in the seasonally polyphenic butterfly Bicyclus anynana is consistent with the characteristics of an organizational effect. By measuring hormone titer levels, quantifying hormone receptor gene expression in the brain, and performing hormone manipulations, we demonstrate steroid hormone signaling early in pupal development has a latent effect on adult male sexual behavior in B. anynana. These findings suggest the organizational/activational paradigm may be more highly conserved across animal taxa than previously thought.

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Section: Methodsmentioning

confidence: 99%

Steroid hormone signaling during development has a latent effect on adult male sexual behavior in the butterfly Bicyclus anynana

2017

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“…On the one hand, some studies have failed to confirm the lifespan effects of natural variants of candidate longevity genes (Geiger-Thornsberry and Mackay, 2004). On the other hand, there is increasing evidence that genetic variation in candidate longevity genes might indeed contribute to variation in lifespan, as well as life history traits, in natural populations (Schmidt et al, 2000; Paaby and Schmidt, 2008; Suh et al, 2008; Paaby et al, 2010; Rose et al, 2010, 2011; Pijpe et al, 2011; Luisi et al, 2012). …”

Section: Evolutionary Implications Of Longevity-modulating Neuronal Mmentioning

confidence: 99%

Neuronal Inputs and Outputs of Aging and Longevity

Alcedo¹,

Flatt²,

Pasyukova³

2013

Front. Genet.

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An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system. Here we highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity. Accordingly, we discuss how sensory inputs influence homeostasis and lifespan through the modulation of different types of neuronal signals, which reflects the complexity of the environmental cues that affect physiology. We also describe feedback, compensatory, and feed-forward mechanisms in these longevity-modulating pathways that are necessary for homeostasis. Finally, we consider the temporal requirements for these neuronal processes and the potential role of natural genetic variation in shaping the neurobiology of aging.

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“…For example, Indy expression is reduced by caloric restriction in flies [55], whereas caloric restriction increases INDY expression in bicyclus anynana butterflies [59]. In mice, starvation over 36 hours reduces mINDY expression in the liver [3].…”

Section: Slc13a5 – Structure Expression and Functionmentioning

confidence: 99%

The Role of Indy in Metabolic Regulation

Willmes

Birkenfeld

2013

Computational and Structural Biotechnology Journal

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Reduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc13a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ß-oxidation. This review will provide an overview on different mammalian SLC1 3 family members with a focus on mINDY (SLCl3A5) in glucose and energy metabolism and will highlight the role of mINDY as a putative therapeutic target for the treatment of obesity, non-alcoholic fatty liver disease and type 2 diabetes.

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Changed gene expression for candidate ageing genes in long-lived Bicyclus anynana butterflies

Cited by 18 publications

References 49 publications

Steroid hormone signaling during development has a latent effect on adult male sexual behavior in the butterfly Bicyclus anynana

Steroid hormone signaling during development has a latent effect on adult male sexual behavior in the butterfly Bicyclus anynana

Neuronal Inputs and Outputs of Aging and Longevity

The Role of Indy in Metabolic Regulation

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