Changed ACC-DMN functional connectivity after acupuncture with deqi for functional dyspepsia treatment

Sun, Ruirui; Ma, Peihong; He, Zhaoxuan; Yin, Tao; Qu, Yuzhu; Yin, Shuai; Liu, Xiaoyan; Jin, Lu; Zhang, Tingting; Huang, Liuyang; Suo, Xueling; Lei, Du; Gong, Qiyong; Liang, Fanrong; Zeng, Fang

doi:10.1016/j.wjam.2020.10.009

Cited by 6 publications

(18 citation statements)

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“…This study ultimately included 10 RCTs, including 4 FD studies [ 21 , 23 – 26 ], 3 IBS studies [ 27 – 29 ], and 3 FC studies [ 30 – 32 ]. All studies used the Roman diagnostic criteria, published from 2012 to 2021, and included a total of 474 participants, 406 of whom completed fMRI.…”

Section: Resultsmentioning

confidence: 99%

“…The intervention measures in the treatment groups were acupuncture, including MA, EA and TEA. Six of the studies used sham acupuncture (SA) [ 21 , 23 , 24 , 26 , 28 ] or waiting for treatment [ 31 , 32 ] as controls, and three used moxibustion [ 25 , 27 , 29 ] or medication (polyethylene glycol) as controls [ 30 ]. All studies reported the results of brain fMRI, of which three IBS [ 27 – 29 ] studies used event-related fMRI, and the rest used resting state fMRI.…”

Section: Resultsmentioning

confidence: 99%

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Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies

Wang,

Luo,

Qing

et al. 2024

BMC Gastroenterol

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Background Functional gastrointestinal disorders (FGIDs) are closely related to disorders of brain-gut interaction. FGIDs are the dominant disease of acupuncture treatment, which can improve the symptoms and emotional state. Aim To evaluate the results and quality of the available clinical evidence and to summarize the central mechanism and effect of acupuncture on FGIDs. Methods PubMed, EMBASE, Web of science, Cochrane Library, China National Knowledge Infrastructure (CNKI) were searched by computer to collect the randomized controlled trials (RCTs), which contained central mechanisms via fMRI research of acupuncture in the treatment of FGIDs patients. The search time limit was from the establishment of the database to June 22, 2022. Two researchers independently screened the literature, extracted data, and evaluated the quality. Results Ten RCTs involving fMRI data were included in this study, including 4 Functional dyspepsia (FD) studies, 3 irritable bowel syndrome (IBS) studies, and 3 functional constipation (FC) studies. The score of improvements in both gastrointestinal symptoms and psychological symptoms showed that acupuncture could significantly improve the clinical symptoms of FGIDs patients, including abdominal pain, abdominal distension, frequency of defecation, and stool characteristics, and could relieve anxiety and depression symptoms of patients. Acupuncture could regulate brain functional connections and functional activity in FGIDs patients, mainly including insula, anterior cingulate cortex, prefrontal cortex, thalamus, hippocampus, amygdala and other brain regions. Conclusion Acupuncture can improve gastrointestinal symptoms and psychological status in FGIDs patients, and regulate functional connectivity and activity of brain regions such as insula, ACC, PFC, thalamus, HIPP, amygdala, etc. These changes in brain activity may related to visceral sensation, pain regulation, emotion, but further studies of high quality are still necessary.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies

Wang,

Luo,

Qing

et al. 2024

BMC Gastroenterol

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“…Our previous study also showed that DMN in FD patients may indeed undergo dysfunctional changes, with changes in DMN found to be related to FD symptom severity ( Liu et al, 2013 ). More importantly, a number of studies have reported that acupuncture can reverse the disrupted DMN to achieve therapeutic effects in gastrointestinal disease ( Bao et al, 2017 ; Sun et al, 2021a , b ; Zhao et al, 2021 ). In these studies, needling at ST36 regulated the rsFC between the left postcentral gyrus with DMN.…”

Section: Discussionmentioning

confidence: 99%

Neural Responses of Acupuncture for Treating Functional Dyspepsia: An fMRI Study

Dong

Yin

et al. 2022

Front. Neurosci.

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Different acupoints exhibiting similar therapeutic effects are a common phenomenon in acupuncture clinical practice. However, the mechanism underlying this phenomenon remains unclear. This study aimed to investigate the similarities and differences in cerebral activities elicited through stimulation of CV12 and ST36, the two most commonly used acupoints, in the treatment of gastrointestinal diseases, so as to partly explore the mechanism of the different acupoints with similar effects. Thirty-eight eligible functional dyspepsia (FD) patients were randomly assigned into either group A (CV12 group) or group B (ST36 group). Each patient received five acupuncture treatments per week for 4 weeks. The Symptom Index of Dyspepsia (SID), Nepean Dyspepsia Symptom Index (NDSI), and Nepean Dyspepsia Life Quality Index (NDLQI) were used to assess treatment efficacy. Functional MRI (fMRI) scans were performed to detect cerebral activity changes at baseline and at the end of the treatment. The results demonstrated that (1) improvements in NDSI, SID, and NDLQI were found in both group A and group B (p < 0.05). However, there were no significant differences in the improvements of the SID, NDSI, and NDLQI scores between group A and group B (p > 0.05); (2) all FD patients showed significantly increased amplitude of low-frequency fluctuation (ALFF) in the left postcentral gyrus after acupuncture treatment, and the changes of ALFF in the left postcentral gyrus were significantly related to the improvements of SID scores (r = 0.358, p = 0.041); and (3) needling at CV12 significantly decreased the resting-state functional connectivity (rsFC) between the left postcentral gyrus and angular gyrus, caudate, middle frontal gyrus (MFG), and cerebellum, while needling at ST36 significantly increased the rsFC between the left postcentral gyrus with the precuneus, superior frontal gyrus (SFG), and MFG. The results indicated that CV12 and ST36 shared similar therapeutic effects for dyspepsia, with common modulation on the activity of the postcentral gyrus in FD patients. However, the modulatory pattern on the functional connectivity of the postcentral gyrus was different. Namely, stimulation of CV12 primarily involved the postcentral gyrus–reward network, while stimulation of ST36 primarily involved the postcentral gyrus–default mode network circuitry.

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“…This effect suggests a strong involvement of segmental inhibition through A-fiber signaling ( 26 ). “Tolerance intensity” was verbally described as “high to tolerable but sub-noxious” and higher than “strong but comfortable,” and there were acupuncture sensations of fullness, heaviness, dull aching, or warmth ( 34 , 35 ). The acupuncture sensation also suggests that Aδ and, possibly, C afferent fibers are activated.…”

Section: Discussionmentioning

confidence: 99%

Caffeine Attenuates Electroacupuncture Effect on Pressure Pain Threshold and Tolerance in Healthy Individuals: A Randomized Controlled Trial

et al. 2022

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IntroductionThe effect of caffeine on acupuncture analgesia in humans is unclear. This study aimed to investigate whether caffeine-containing beverage intake influences the effect of electroacupuncture (EA) on static quantitative sensory testing (QST) and dynamic QST in healthy subjects.MethodsA total of 40 healthy subjects were enrolled and randomly assigned to receive coffee containing moderate doses of caffeine (coffee group) or non-caffeinated juice (juice group) for 4 weeks. The primary outcome measures were the pressure pain threshold (PPT), pressure pain tolerance (PPTo), and heat pain threshold (HPT) as static QST parameters. Numerical rating scales (NRS) of heat stimulus and nociceptive flexor reflex (RIII reflex), as parameters of dynamic QST, were also examined. EA stimulation with tolerance intensity was performed at ST36 (Zusanli)-GB34 (Yanglingquan) points at weeks 0, 2, and 4. PPT, PPTo, and HPT were detected pre- and post- EA. The NRS scores were examined pre-, during, and post-EA, and 1 min after EA was completed. The RIII reflex was examined pre- and 1–5 min post-EA.ResultsAt week 0, both groups showed increased PPT and PPTo and decreased NRS scores of heat stimuli and RIII reflex after EA, but HPT was not affected. After 4 weeks, the effects of EA on PPT and PPTo were attenuated in the coffee group compared to the juice group, whereas the effect of EA on the NRS scores and RIII reflex were not influenced. There was no significant difference found at week 2 for these indications. EA also did not affect the HPT in both groups at week 4.ConclusionModerate caffeine intake reduced the effects of EA on PPT and PPTo in healthy subjects.

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Changed ACC-DMN functional connectivity after acupuncture with deqi for functional dyspepsia treatment

Cited by 6 publications

References 58 publications

Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies

Symptom effects and central mechanism of acupuncture in patients with functional gastrointestinal disorders: a systematic review based on fMRI studies

Neural Responses of Acupuncture for Treating Functional Dyspepsia: An fMRI Study

Caffeine Attenuates Electroacupuncture Effect on Pressure Pain Threshold and Tolerance in Healthy Individuals: A Randomized Controlled Trial

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