Change with age in muscular mechanical hyperalgesia after lengthening contraction in rats

Taguchi, Toru; Matsuda, Teru; Mizumura, Kazue

doi:10.1016/j.neures.2006.11.004

Cited by 10 publications

(8 citation statements)

References 40 publications

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“…In experimental animals effects of aging on deep nociceptive behaviors to mechanical stimulation are not uni‐directional as in human psychophysical studies. We have observed that the muscular mechanical withdrawal threshold in aged Sprague—Dawley rats (130‐week‐old) was not different from that in young (7‐week‐old) rats (Taguchi et al, 2007), whereas the threshold measured by the paw pressure test (mainly reflecting the deep nociceptive threshold) decreased in the aged Lou/C/Jall rats (Jourdan et al, 2000).…”

Section: Introductionmentioning

confidence: 79%

“…In spite of the augmented mechanical response of C‐afferents, the mechanical withdrawal threshold measured by the Randall—Selitto test was found to be unchanged between young and aged S—D rats (Taguchi et al, 2007). It has been reported that the number of unmyelinated afferents decreases with increasing age (Nakayama et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Impairment of the descending inhibitory pain control system has also been suggested (Iwata et al, 2002), and the changes described above are considered to be due to this impairment. We also reported that the spinal segment with nociceptive input from the tender muscle was expanded in aged animals after lengthening contraction (Taguchi et al, 2007).…”

Section: Introductionmentioning

confidence: 90%

“…Although potential effects of dietary restriction on muscular nociceptors in S-D rats is unknown, it is suitable for chronic studies because it makes them live longer (Duffy et al, 2002) and has relative protective effects on spontaneous cardiomyopathy (Kemi et al, 2000). We used such dietary restriction as in this study also to compare electrophysiological data with the behavioral outcomes obtained in our previous study (Taguchi et al, 2007). Filtered clean water was freely available.…”

Section: Animalsmentioning

confidence: 99%

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Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Taguchi

Mizumura

2011

European Journal of Pain

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Musculoskeletal pain deteriorates quality of life by disrupting daily activities and is a considerable economic burden to many countries because of the large number of patients. Little is known about the peripheral neural mechanisms of muscular nociception in the aged, although structural and functional changes in the muscle are apparent as a function of age. The aim of the present study was to investigate the activities of aged muscle nociceptors systematically to mechanical, chemical and thermal stimuli, and to compare with the data from young animals. Activities of single C-fibers were recorded from in vitro preparations of extensor digitorum longus muscle-nerve excised from hind legs of aged rats (125-133 weeks). Mechanical threshold measured by a ramp mechanical stimulus in the aged muscle (median; 45.2 mN (IQR; 38.1-59.1 mN), n=29) was significantly lower than that in the younger muscle (median; 65.4 mN (IQR; 46.6-122.0 mN), n=33, p<0.01, Mann-Whitney U-test) reported in our previous study (Taguchi et al., 2005). In addition, the magnitude of the mechanical response during the first 5s of the 10s stimulus was significantly greater in the aged muscle (11.0 spikes (IQR; 6.5-20.5 spikes)) than in the young (7.0 spikes (IQR; 4.0-11.5 spikes), p<0.05, Mann-Whitney U-test). In contrast, the numbers of discharges induced by chemical (pH 5.5, ATP and bradykinin) and thermal (cold and heat) stimuli were not different with the different ages. These results showed an augmented mechanical response in muscle C-afferents in the aged rats.

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Animalsmentioning

confidence: 99%

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Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Taguchi

Mizumura

2011

European Journal of Pain

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“…Delayed onset muscle soreness can be induced in animals/humans either by electrically contracting muscle while it is being stretched [i.e., LC; Figure 1] (2,5,6) or by downhill running (7). In humans, DOMS can be experimentally induced in different muscles by slowly and voluntarily moving weights (3) or foot (8) downwards.…”

Section: Findings Trigger Point-like Changes In Experimentally Inducementioning

confidence: 99%

Animal Models of Myofascial Trigger Points

Mizumura

Murase

Taguchi

2010

Journal of Musculoskeletal Pain

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Objective: One of the typical symptoms of myofascial pain syndrome is trigger points [TrPs] in a taut band. It has been reported that hyperalgesic muscle [delayed onset muscle soreness or DOMS] after lengthening contraction [LC] has similarities with clinical TrPs, such as mechanically sensitive spots in hardening of the muscle, and electromyographic activities. Using this model we studied the mechanism by which DOMS is generated and maintained.Findings: We found that bradykinin released during exercise triggers nerve growth factor [NGF] upregulation in the muscle through the activation of B2 bradykinin receptors. NGF upregulation started 12 hours after LC, and lasted for one to two days, a compatible time course for muscle mechanical hyperalgesia. Injection of anti-NGF antibody into the exercised muscle two days after LC reversed the mechanical hyperalgesia. NGF sensitized muscle thin-fiber receptors recorded in vitro to mechanical stimulation after a short latency of 10 to 20 minutes.Conclusions: The sensitization of muscle nociceptors to mechanical stimulation by NGF upregulated in the muscle after LC is considered to be a mechanism for mechanical hyperalgesia after exercise. Determining whether there is any difference in expression of NGF or sensitivity of muscle nociceptors in the TrP and in other areas will be an important key for clarifying the mechanism of TrPs. ferred pain to remote structures, and local twitch response (1). Its etiology is not known. To understand this etiology, animal experiments will be useful. Itoh et al. (2, 3) found TrP-like sensitive spots in the hardened part in the muscle/fascia after lengthening [eccentric] contraction [LC], both in an animal model [rabbits] and humans

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Muscular Pain Mechanisms: Brief Review with Special Consideration of Delayed-Onset Muscle Soreness

Mizumura

Novel Trends in Brain Science

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Change with age in muscular mechanical hyperalgesia after lengthening contraction in rats

Cited by 10 publications

References 40 publications

Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Animal Models of Myofascial Trigger Points

Muscular Pain Mechanisms: Brief Review with Special Consideration of Delayed-Onset Muscle Soreness

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