Change of visfatin, C-reactive protein concentrations, and insulin sensitivity in patients with hyperthyroidism

Chu, Chih-Hsun; Lee, Jenn-Kuen; Wang, Mei-Chun; Lu, Chien Chen; Sun, Chun-Chin; Chuang, Ming-Ju; Lam, Hing‐Chung

doi:10.1016/j.metabol.2008.05.006

Cited by 26 publications

(26 citation statements)

References 27 publications

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“…Possible explanation for these results may be the differences in the study population, as well as the sample size. Our results also confirm the previous data that CRP levels are not different from controls in hyperthyroidic patients [60, 61]. …”

Section: Discussionsupporting

confidence: 93%

Role of Surrogate Markers of Atherosclerosis in Clinical and Subclinical Thyroidism

Gündüz

Kırçelli³

et al. 2012

International Journal of Endocrinology

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Background. Data on the relationship between homocysteine, plasminogen activator inhibitor 1, hs-CRP, fibrinogen, and carotid intima media thickness (CA-IMT) is plenty but contradicting and the majority of the studies investigated this issue in only specific thyroidism groups. The aim of this paper was to investigate these relations in patients with subclinical and clinical hypo- and hyperthyroidism. Methods. In this cross-sectional study, 16 patients from each thyroidism group and 20 healthy cases were enrolled. Fibrinogen levels and plasminogen activator inhibitor 1 (PAI-1) activity were assessed. CA-IMT was determined by gray-scale high-resolution color Doppler ultrasound. Results. Serum homocysteine levels were higher in hypothyroidic patients compared to the control (P = 0.003). Fibrinogen levels were higher in patients with subclinical hypothyroidism compared to other groups (P < 0.05). There was no difference between groups regarding PAI-1. Whereas total cholesterol, homocysteine, and LDL were correlated with CAIMT, hs-CRP, PAI-1, and fibrinogen were not. In the clinical hypothyroidism group, the correlation of homocysteine with CA-IMT was derived from the correlation between CA-IMT and homocysteine. Conclusions. Homocysteine and fibrinogen levels are higher in patients with clinical and subclinical hypothyroidism, respectively. Homocysteine level is associated with CA-IMTonly in patients with clinical hypothyroidism.

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Section: Discussionsupporting

confidence: 93%

Role of Surrogate Markers of Atherosclerosis in Clinical and Subclinical Thyroidism

Gündüz

Kırçelli³

et al. 2012

International Journal of Endocrinology

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“…Only two studies have evaluated visfatin levels in hyperthyroidism so far. The first study showed increased plasma visfatin concentration in hyperthyroid patients and a decrease after treatment; however, these levels were not associated with indices of insulin resistance (148). These findings contrast with the results of the second study in hyperthyroid patients that found low visfatin levels that were increased after antithyroid therapy (149).…”

Section: F Visfatinmentioning

confidence: 73%

Insulin Action in Hyperthyroidism: A Focus on Muscle and Adipose Tissue

2010

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Hyperthyroidism leads to an enhanced demand for glucose, which is primarily provided by increased rates of hepatic glucose production due to increased gluconeogenesis (in the fasting state) and increased Cori cycle activity (in the late postprandial and fasting state). Adipose tissue lipolysis is increased in the fasting state, resulting in increased production of glycerol and nonesterified fatty acids. Under these conditions, increased glycerol generated by lipolysis and increased amino acids generated by proteolysis are used as substrates for gluconeogenesis. Increased nonesterified fatty acid levels are necessary to stimulate gluconeogenesis and provide substrate for oxidation in other tissues (such as muscle). In the postprandial period, insulin-stimulated glucose uptake by the skeletal muscle has been found to be normal or increased, mainly due to increased blood flow. Under hyperthyroid conditions, insulin-stimulated rates of glycogen synthesis in skeletal muscle are decreased, whereas there is a preferential increase in the rates of lactate formation vs. glucose oxidation leading to increased Cori cycle activity. In hyperthyroidism, the Cori cycle could be considered as a large substrate cycle; by maintaining a high flux through it, a dynamic buffer of glucose and lactate is provided, which can be used by other tissues as required. Moreover, lipolysis is rapidly suppressed to normal after the meal to facilitate the disposal of glucose by the insulin-resistant muscle. This ensures the preferential use of glucose when available and helps to preserve fat stores.

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“…The study enrolled 19 patients with hyperthyroidism due to Graves' disease (14 women and 5 men) and 19 age- and sex-matched euthyroid controls (17 women and 2 men) as previous study mentioned [12]. All hyperthyroid patients were treated with antithyroid drugs, either propylthiouracil (procil, Nysco Co., Ltd., Taiwan) or carbimazole (neo-thyreostat, Dr. Herbrand Co., Ltd., Germany).…”

Section: Methodsmentioning

confidence: 99%

Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels

Chu

Lam

Lee

et al. 2011

Journal of Thyroid Research

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To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls. All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized. Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group. The adiponectin levels remained unchanged after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) in hyperthyroid group was higher before treatment than after treatment. There was no significant difference in serum glucose and insulin levels between hyperthyroid and control groups and in the hyperthyroid group before and after treatment. BMI-adjusted adiponectin levels were not different among three groups. On the other hand, BMI-adjusted insulin levels and HOMA-IR values were significantly decreased after management of hyperthyroidism. Pearson's correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels. However, adiponectin did not correlate with T3, FT4, insulin, HOMA-IR and thyrotropin receptor autoantibody (TRAb) levels. In conclusion, insulin resistance associated with hyperthyroidism is not mediated by the levels of plasma adiponectin.

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Change of visfatin, C-reactive protein concentrations, and insulin sensitivity in patients with hyperthyroidism

Cited by 26 publications

References 27 publications

Role of Surrogate Markers of Atherosclerosis in Clinical and Subclinical Thyroidism

Role of Surrogate Markers of Atherosclerosis in Clinical and Subclinical Thyroidism

Insulin Action in Hyperthyroidism: A Focus on Muscle and Adipose Tissue

Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels

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