Change of the initiation time of blood coagulation in pregnancy from 10-months to postpartum

Abstract

We measured the time of initiation of blood coagulation (Ti) from pregnancy 10-months (36∼40 weeks) till 1-month after delivery, paying particular attention to the very early postpartum period, using a damped oscillation rheometer that is approximately 160 times more sensitive than the Thromboelastogram ® to evaluate the risk of thrombus formation. Blood samples were obtained from healthy volunteers at pregnancy 10-month, 1-hour, 3-hours, 4-days, 7-days, 3-weeks and 1-month after delivery. Ti values at pregnancy 10-month, 1-hour, 3-hours, 4-days, 7-days, 3-weeks, 1-month after delivery and in non-pregnant females were 20.4 ± 2.2, 11.7 ± 1.6, 13.2 ± 3.1, 17.2 ± 2.0, 20.2 ± 1.6, 21.4 ± 4.0, 24.6 ± 3.6, and (25.0 ± 3.4) minutes, respectively. Ti was significantly shorter at pregnancy 10-month, 1-hour, 3-ours, 4-days, 7-days and 3-weeks after delivery than in non-pregnant females. These data show that the blood of pregnant females is more hypercoagulable than nonpregnant females from pregnancy 10-month until 3-weeks post delivery, suggesting that they are at high risk of VTE after discharge from hospital.

Integrated Proteotranscriptomics of Human Myometrium in Labor Landscape Reveals the Increased Molecular Associated With Inflammation Under Hypoxia Stress

“…Other important pathways enriched in the IL myometrium included those involved in hemostasis and extracellular matrix organization. Procoagulant factor-dependent activation increases immediately after placenta delivery to prevent excessive blood loss, while excessive coagulation increases the risk of venous thromboembolism in puerperal women ( 39 ). The results of our analysis indicate that the activity regulation of the coagulation system starts as early as labor.…”

The effects of medium cut-off and high-flux membranes on activated clotting time of patients on hemodialysis

“…Firstly, this physical characteristic of that membrane leads to a higher ultrafiltration rate and, consequently, to hemoconcentration inside the dialyzer ( 21 ). It is well known that the initial blood coagulation reaction could be accelerated under a hemoconcentration state ( 22 ). Interestingly, patients undergoing post-dilution hemodiafiltration that favors hemoconcentration within the dialyzer may need to increase the heparin dose ( 23 ).…”

Perioperative management of patients with hemostatic system disorders. Methodological recommendations of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists” and the National Association of Specialists in Thrombosis, Clinical Hemostasiology and Hemorheology

“…Определенный вклад в геморрагии вносит анемия: после гемотрансфузии уменьшается время кровотечения и геморрагический синдром. Эритроциты являются важнейшим звеном функционирования системы гемостаза: они модулируют ответ активированных тромбоцитов, активируют ЦОГ тромбоцитов, усиливают выработку тромбоксана А 2 и являются донаторами АДФ; кроме того, они вытес няют тромбоциты ближе к стенке сосуда с увеличением их концентрации в данной «целевой зоне» до семикрат ной по отношению к значению, определяемому гемато логическим анализатором [9][10][11].…”