Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study

Lee, Yong Seop; Tae, Kyung; Lee, Seung Hwan; Cho, Seok Hyun; Jeong, Jin Hyeok; Min, Hyun Jung; Ji, Yong Bae

doi:10.1007/s12094-011-0727-5

Cited by 2 publications

(3 citation statements)

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“…Similar results have also been reported by Fabricius and Koscielny et al 29,39 So far, only one study has answered whether telomerase can serve as an indicator of disease status in follow up. 26 The study evaluated telomerase activity in peripheral whole blood from HNSCC patients as a biomarker for diagnosis or detection of recurrence during follow-up. Among 41 HNSCC patients who showed positive telomerase activity before surgery, 32 (78.1%) showed a conversion of telomerase activity to negative after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…27,40 Two mechanisms have been hypothesized to explain this finding. 26 First, PBMC could be activated by soluble factors, secreted either by cancer or by the tumor microenvironment. Mean serum vascular endothelial growth factor levels have, indeed, been significantly linked with telomerase activity in PBMCs in HNSCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, the only study that has investigated the significance of TERT mRNA plasma levels in HNSCC patients reported that the values were indeed significantly elevated before surgery and that they decreased significantly two days after surgery. 26 Telomerase activity alone has also been studied in the past, but majority of the studies were done on populations different from those found in India. The etiology of the disease in India is completely different from other countries.…”

Section: Introductionmentioning

confidence: 99%

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Change of telomerase activity in peripheral blood of patients with head and neck squamous cell carcinoma pre and post curative treatment

Ganesh

Narayanan

Kumar

2020

Reports of Practical Oncology & Radiotherapy

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Background: There is no clinically applicable tumor marker for head and neck cancers. Telomerase is detected in approximately 90% of all malignant tumors, it may predict poor or favorable outcomes, thus being both a highly attractive biomarker and a target for the development of molecular-based cancer diagnostics, prognostics, and therapeutics Aim: Primary aim was to detect a change of telomerase activity before and after curative treatment.Materials and Methods: Patients with biopsy proven head and neck squamous cell carcinoma, stage I-IVB treated with a curative intent, performance status 0-2 and malignancy at one primary site were included in the study. Telomerase levels were tested in tissue biopsy.Plasma telomerase levels were tested at baseline, 5 days and at 3 months after treatment using ELISA.Results: Raised plasma telomerase activity was seen in all the patients with cancer at baseline. The mean plasma telomerase level at baseline was 861.4522 ng/ml, at 5 days after completion of curative treatment was 928.92 ng/ml and at 3 months of follow up was 898.87 ng/ml. The mean tissue biopsy telomerase level was 19768.53 ng/mg. There was a significant increase in baseline telomerase levels in cancer patients compared to normals (volunteers) (t = −3.52, p = 0.001).There was a significant increase in plasma levels of telomerase at 3 months compared to baseline values (z = −1.98, p = 0.04). The increase in telomerase level did not correlate with the response of the treatment. Conclusion:In patients with head and neck squamous cell carcinomas treated with a curative intent, the change in levels of telomerase correlates neither with the disease status nor with prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Change of telomerase activity in peripheral blood of patients with head and neck squamous cell carcinoma pre and post curative treatment

Ganesh

Narayanan

Kumar

2020

Reports of Practical Oncology & Radiotherapy

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Urine Telomerase for Diagnosis and Surveillance of Bladder Cancer

Lamarca

Barriuso²

2012

Advances in Urology

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Bladder cancer has increased incidence during last decades. For those patients with nonmuscle involved tumors, noninvasive diagnosis test and surveillance methods must be designed to avoid current cystoscopies that nowadays are done regularly in a lot of patients. Novel urine biomarkers have been developed during last years. Telomerase is important in cancer biology, improving the division capacity of cancer cells. Even urinary telomerase could be a potentially useful urinary tumor marker; its use for diagnosis of asymptomatic and symptomatic patients or its impact during surveillance is still unknown. Moreover, there will need to be uniformity and standardization in the assays before it can become useful in clinical practice. It does not seem to exist a real difference between the most classical assays for the detection of urine telomerase (TRAP and hTERT). However, the new detection methods with modified TeloTAGGG telomerase or with gold nanoparticles must also be taken into consideration for the correct development of this diagnosis method. Maybe the target population would be the high-risk groups within screening programs. To date there is no enough evidence to use it alone and to eliminate cystoscopies from the diagnosis and surveillance of these patients. The combination with cytology or FISH is still preferred.

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Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study

Cited by 2 publications

References 24 publications

Change of telomerase activity in peripheral blood of patients with head and neck squamous cell carcinoma pre and post curative treatment

Change of telomerase activity in peripheral blood of patients with head and neck squamous cell carcinoma pre and post curative treatment

Urine Telomerase for Diagnosis and Surveillance of Bladder Cancer

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