Change of sign in the Casimir interaction of peptide films deposited on a dielectric substrate

Velichko, Elena; Baranov, Maksim; Mostepanenko, V. M.

doi:10.1142/s0217732320400209

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…As already noted, the stability of molecular films has a critical effect on their applicability for the purposes of biomolecular electronics [ 29 , 70 , 74 , 75 ]. Since the current general trend towards the miniaturization of electronic components has led to the creation of thinner molecular films, the problem of their stability has become more urgent [ 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since the current general trend towards the miniaturization of electronic components has led to the creation of thinner molecular films, the problem of their stability has become more urgent [ 76 , 77 ]. In previous work, the authors showed that as film thickness decreases, its stability is influenced by fluctuation forces [ 29 , 70 , 75 ]. The possibility of such an influence was predicted on the basis of previous studies [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

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Aggregation Properties of Albumin in Interacting with Magnetic Fluids

Velichko

Nepomnyashchaya

Baranov

et al. 2021

IJMS

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In this study, interactions of Fe3O4 magnetic nanoparticles with serum albumin biomolecules in aqueous solutions were considered. The studies were conducted with the laser correlation spectroscopy and optical analysis of dehydrated films. It was shown that the addition of magnetite to an albumin solution at low concentrations of up to 10−6 g/L led to the formation of aggregates with sizes of up to 300 nm in the liquid phase and an increase in the number of spiral structures in the dehydrated films, which indicated an increase in their stability. With a further increase in the magnetite concentration in the solution (from 10−4 g/L), the magnetic particles stuck together and to albumin, thus forming aggregates with sizes larger than 1000 nm. At the same time, the formation of morphological structures in molecular films was disturbed, and a characteristic decrease in their stability occurred. Most stable films were formed at low concentrations of magnetic nanoparticles (less than 10−4 g/L) when small albumin–magnetic nanoparticle aggregates were formed. These results are important for characterizing the interaction processes of biomolecules with magnetic nanoparticles and can be useful for predicting the stability of biomolecular films with the inclusion of magnetite particles.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aggregation Properties of Albumin in Interacting with Magnetic Fluids

Velichko

Nepomnyashchaya

Baranov

et al. 2021

IJMS

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“…Non-covalent dispersion van der Waals interactions are also thought to play an important role in protein folding [ 16 ] since they make a substantial contribution to protein–protein as well as protein–water interactions [ 17 ]. Additionally, in applications tied to organic optical and electronic devices as well as biotechnology, the contribution of van der Waals interactions to the stability of proteinaceous films deposited on a dielectric substrate has been recently noted [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Even though the dielectric properties of various metals, semiconductors, and insulators, organic as well as inorganic, have been critically assessed in great detail [ 14 ], the dielectric spectrum data for proteins and polypeptides mostly lack the relevant details regarding the optical properties in a wide frequency range from zero frequency to the far ultraviolet [ 18 ]. In the absence of relevant experimental data, the calculated ultraviolet frequency region dielectric spectra for the cyclic tripeptide RGD-4C (1FUV) [ 20 ], based on an ab initio quantum mechanical (QM) computational scheme, were successfully used to calculate the oscillator strengths, oscillator frequencies, and the relaxation parameters that enter the calculations of the van der Waals interactions in proteinaceous systems [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

First-Principles Simulation of Dielectric Function in Biomolecules

et al. 2021

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The dielectric spectra of complex biomolecules reflect the molecular heterogeneity of the proteins and are particularly important for the calculations of electrostatic (Coulomb) and electrodynamic (van der Waals) interactions in protein physics. The dielectric response of the proteins can be decomposed into different components depending on the size, structure, composition, locality, and environment of the protein in general. We present a new robust simulation method anchored in rigorous ab initio quantum mechanical calculations of explicit atomistic models, without any indeterminate parameters to compute and gain insight into the dielectric spectra of small proteins under different conditions. We implement this methodology to a polypeptide RGD-4C (1FUV) in different environments, and the SD1 domain in the spike protein of SARS-COV-2. Two peaks at 5.2–5.7 eV and 14.4–15.2 eV in the dielectric absorption spectra are observed for 1FUV and SD1 in vacuum as well as in their solvated and salted models.

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“…Obviously, changes in the control parameter will result in biomolecular thin films of various types and properties. These properties (electrical, optical, mechanical) can be predicted by studying the structures formed as a result of self-organization processes [14][15][16]. Thus, it is necessary to determine the characterization parameters and select methods for studying the resulting dissipative structures.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Fractal Structures in Dehydrated Films of Protein Solutions

2021

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The article deals with dendritic structures resulting from self-organization processes in aqueous solutions of albumin proteins. The methods for obtaining the structures and experimental results are presented. It is shown that dendrites are fractal structures that are symmetric under certain conditions of their formation and can have different characteristics depending on the isothermal dehydration of liquid samples. The fractal dimension of the structures in films of the albumin protein solution has been calculated. Dependences of the fractal dimension on the concentrations of salts and protein in the initial solutions and also on the dehydration temperature have been revealed. It has been shown that as the protein concentration in the solution grows, the salt concentration for the initiation of the dendritic structure formation increases. It has been found that the temperature dependences of the fractal dimension of the structures become smoother with increasing protein concentration in solutions. The relationship between geometric characteristics of dendrites and self-organization parameters during drying is discussed.

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Change of sign in the Casimir interaction of peptide films deposited on a dielectric substrate

Cited by 13 publications

References 35 publications

Aggregation Properties of Albumin in Interacting with Magnetic Fluids

Aggregation Properties of Albumin in Interacting with Magnetic Fluids

First-Principles Simulation of Dielectric Function in Biomolecules

Analysis of Fractal Structures in Dehydrated Films of Protein Solutions

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