Change of parameters in prooxidant-antioxidant bile system in patients with the obstruction of bile-excreting ducts

Abstract

The paper found that among the patients with choledocholithiasis and malignant neoplasms of biliopancreatoduodenalis area in the development of cholangitis it is observed a significant reduction in the capacity of the antioxidant system at the local level (in bile) by 78.3% and 72.9%, respectively. The paper showed that for the evaluation of the degree of decompensation in antiradical protection in biliary obstruction and inflammatory complications it is necessary to determine as additional indicators in bile the state level of the enzymes in the antioxidant system: the activity of catalase and superoxidedismutase that could improve the diagnosis in these pathological conditions and in addition would allow to appoint timely corrective actions and monitor the effectiveness of the therapy. The study showed that the catalase activity increased in the bile in patients with choledocholithiasis as compared to control values by 1.7 times in the absence of inflammatory complications and by 5.1 times-under cholangitis; in patients with malignant neoplasms of biliopancreatoduodenalis area its activity decreased by 49.4% while decreasing the area of maximum chemoluminescence by 42.2% and 72.5% respectively, whereas in the development of cholangitis the catalase activity increased by 4.5 times. In this case the increase in superoxidedismutase activity in all study groups was even more significant, indicating the adaptive changes, as well as the emerging imbalance in the enzymes of the 1st and 2nd line of the antioxidant system (mainly due to dismutase activity), which might be accompanied by a decrease in local nonspecific resistance, especially in inflammatory complications in patients with the studied nosologies.

Active Dynamics of the Enzymes of the Antiradical Protection and the General Antioxidative Activity by the Development of the Experimental Ischemic Reperfusion of Liver

“…The imbalance between the tissue necessity in oxygen and its delivery as well as the rapid increase of its partial pressure in the liver tissue after the circulative restoration provides favorable conditions for the formation of free radicals (superoxide anion, hydrogen peroxide, and hydroxyl radical). In its turn that leads to the activation of processes concerning the peroxide oxidation of lipids which causes the alteration of cellular and subcellular membrane structures of hepatocytes [3][4][5][6][7]. The idea of processes accompanying the ischemic reperfusion of liver may become the basis for developing new scientifically justified methods, which allow improve quality of transplant and other general operations on the organs of the hepatobiliary system and also lowering the risk of postoperative complications.…”

“…Дисбаланс между тканевой потребностью в кислороде и доставкой, а также резкое возрастание его парциального давления в ткани печени после восстановления кровотока создают благоприятные условия для образования свободных радикалов (супероксиданиона, перекиси водорода, гидроксильного радикала). Это в свою очередь приводит к активации процессов перекисного окисления липидов, которое ведет к альтерации клеточных и субклеточных мембранных структур гепатоцитов [3][4][5][6][7]. Представление о механизмах процессов, сопровождающих синдром ишемии-реперфузии печени, может стать основой для разработки новых научно обоснованных методик, позволяющих улучшить качество трансплантационных и других обширных операций на органах гепатобили-арной системы, а также снизить риск развития послеоперационных осложнений.…”

The Functioning Features of Prooxidant-Antioxidant System and Immune Protection During Dental Caries Treatment in Children With Neuropsychiatric Disorders

“…Известно, что нарушение функционирования прооксидантно-антиоксидантной системы [7,8,9], связанное нередко с дисбалансом в работе ее ферментного звена [10,11], сопровождается при ряде соматических заболеваний повышением интенсивности процессов свободнорадикального окисления (СРО) и приводит к развитию окислительного стресса [12][13][14][15], являющегося частой причиной формирования различных осложнений. В связи с тем, что слюна представляет собой сложную жидкость, которая влияет на здоровье полости рта с помощью специфических и неспецифических физико-химических свойств, для оценки состояния неспецифических защитных систем у пациентов со стоматологическими заболевани-ями и коморбидной патологией внутренних органов при диагностике и мониторинге лечебных мероприятий, направленных на повышение адаптационных возможностей организма на местном уровне, все большее внимание в последние годы уделяется поиску новых неинвазивных критериев лабораторного обследования именно с использованием РЖ [16][17][18][19].…”

Changes in rabbits’ liver morphological parameters in simulation of hypoxia corrected by the use of the modified isotopic D/H composition in the water

“…It is known that there is a multi-level antioxidant system and a complex of peroxidation regulatory processes in an organism [21]. At the same time in a hypoxia the concentration of oxygenates increases significantly and takes precedence of a norm by several times: components of peroxidative modification of biomolecules are collected, and their local increase is also regular and correlates with an intensity of a pathologic process causing changes in the cell morphology and internal organs tissues [22,23].…”