Change of Liver Function in Hypertrophying Lobe of Rabbit Liver after Portal Branch Ligation

Urayama, Masahiro; Ishiyama, Shuichi; Kuzumaki, Takejiro; Ishikawa, Kiichi; Fuse, Akira; Kuzu, Hiroshi; Igarashi, Yukio; Suto, Koichi; Tsukamoto, Masaru

doi:10.1006/jsre.1999.5687

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…Therefore, 99m Tc-GSA scintigraphy provides information about both liver function and the volume of active liver, and should be useful in selecting the most appropriate hepatectomy. In patients undergoing PVE, the functions of the atrophic liver and hypertrophic liver may be markedly different, reflecting the morphological changes (17).…”

mentioning

confidence: 99%

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

et al. 2006

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To clarify the relationship between morphological measurements of hepatic volume by computed tomography (CT-vol) and functional volume (RI-vol) by technetium-99m galactosyl human serum albumin (99mTc-GSA) scintigraphy, and its clinical significance, we examined 16 patients with a background liver status of either normal liver function (n=4), chronic hepatitis or cirrhosis (n=7), or obstructive jaundice (n=5). In five patients who underwent preoperative portal vein embolization (PVE), volumetric measurement was performed 2 weeks after PVE. The mean values of CT-vol and RI-vol of the right lobe were 692+/-147 cm3 (66.1+/-10.7%) and 668+/-159 cm3 (67.8+/-13.2%), respectively, and those of the left lobe were 329+/-138 cm3 (33.9+/-10.6%) and 328+/- 170 cm3 (32.2+/-13.2%), respectively. There were no significant differences in the volume measurements between the two volumetric techniques. Correlations between CT-vol and RI-vol in the right and left lobes were positive and significant (r=0.912 and 0.903, respectively; both P's<0.001). The mean values of post-PVE CT-vol and RI-vol of the right lobe in five patients were significantly different (628+/-149 and 456+/-211 cm3, respectively; P=0.033). However, the mean values of post-PVE CT-vol and RI-vol of the left lobe were not different (496+/-124 and 483+/-129 cm3, respectively). We propose that volumetric measurement by 99mTc-GSA scintigraphy is useful for detecting changes in functional volume of individual lobes of the liver and is a more dynamic method compared with detection of morphological changes by CT scan.

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mentioning

confidence: 99%

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

et al. 2006

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“…Although this delayed recovery in liver function is supported by other in vivo animal experiments as well [73,74], some clinical trials are contradicting this observation. Uesaka et al [75] selectively measured the biliary indocyanine green excretion of the nonoccluded lobes after PVO in patients with multiple percutaneous transhepatic biliary drainage and concluded that the increase in function of the regenerating lobes is more pronounced than suggested by the degree of hypertrophy.…”

Section: Functional Regeneration - Other Than Volume Shiftingmentioning

confidence: 68%

Triggered Liver Regeneration: From Experimental Model to Clinical Implications

Szíjártó

Fülöp

2015

Eur Surg Res

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Background: Major liver resection is the only therapeutic option for patients with malignant liver tumors. However, extended hepatectomy often leads to postoperative liver failure, mainly due to insufficient amounts of the remnant liver. Recently, selective portal vein occlusion (PVO) has been introduced to increase the remnant liver volume. This novel surgical technique initiated a progressive development in liver surgery, resulting in a significant increment in potential candidates for curative liver resection. Summary: The theoretical basis for this great advancement is formed by an understanding of the mechanisms of PVO-induced liver regeneration, mainly obtained from animal studies. The aim of this review is to give a comprehensive overview of the relevant animal models of PVO and to discuss the main characteristics of triggered liver regeneration, including the induced hemodynamic, morphological and functional alterations as well as the underlying molecular mechanisms, which might be of interest in both the laboratory and the clinic. Key Messages: Although basic research revealed the main characteristics of PVO-triggered liver regeneration within the last decades, several important issues regarding the regenerative process remain uncertain. To answer these open questions, additional well-designed animal experiments are needed in the future, which allow further refinement of this surgical technique.

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“…In some studies, the ratio of liver or lobes to live weight was also used (Urayama et al, 1999;Aller et al, 2009b). Therefore, these ratios were calculated for rabbits in the study.…”

Section: Discussionmentioning

confidence: 99%

Rabbit Liver Lobes: An Anatomical Study of Experimental Surgical Approaches

Kilimci

2020

Erciyes Üniversitesi Veteriner Fakültesi Dergisi

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A number of animal models have been developed for experimental liver surgery protocols such as lobectomy, ischemia and reperfusion studies, organ injuries, and drug trials. Though, some morphometric studies describe the liver lobes in rats and mice, such anatomical information is not sufficiently available in rabbits. The aim of this study was to evaluate the anatomical approaches for experimental liver resection in the rabbit, and to examine the proportional distribution of each lobe conforming to the whole organ, and to schematize the macroanatomical properties of each lobe.For this purpose, the liver lobes were dissected according to anatomical references. The volumes and weights of the whole organ and the individual lobes were measured. The percentages of the liver lobes were calculated according to the weight and volume of the total liver.The interlobar notch, especially between the medial and lateral parts of the left lobe was more prominent than that between the quadrate and the right lobe. The proportion of the left lateral and medial lobe was 27%, and 24% relative to the total liver weight, similarly, the right lobe, quadrate lobe and the caudate lobe was 19%, 7% and 23%, respectively. The volumetric ratios of liver lobes were also found close to the mass ratios.In conclusion, anatomical information from this study can be used as a reference in performing various experimental surgical studies on the rabbit liver.

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Change of Liver Function in Hypertrophying Lobe of Rabbit Liver after Portal Branch Ligation

Cited by 9 publications

References 17 publications

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

Relationship Between CT Volumetry and Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization Before Major Hepatectomy: A Preliminary Study

Triggered Liver Regeneration: From Experimental Model to Clinical Implications

Rabbit Liver Lobes: An Anatomical Study of Experimental Surgical Approaches

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