Change of Kidney Function Is Associated With All‐Cause Mortality and Cardiovascular Diseases: Results From the Kailuan Study

Guo, Yifan; Ye, Pengpeng; Li, Junjuan; Wu, Shouling; Luo, Yang

doi:10.1161/jaha.118.010596

Cited by 40 publications

(31 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our population, mtDNAcn decreased with age, according to previous evidence examining mtDNAcn in blood cells (Mengel-From et al, 2014). In addition, we found a correlation between mtDNAcn, hypertension and GFR, which are established risk factors for CVD (Flint et al, 2019; Manjunath et al, 2003; Yidan et al, 2018). In particular, mtDNAcn was decreased in hypertensive subjects.…”

Section: Discussionmentioning

confidence: 64%

Mitochondrial DNA copy number and trimethylamine levels in the blood: new insights on cardiovascular disease biomarkers

Bordoni

Petracci

Pelikant‐Małecka

et al. 2021

Preprint

View full text Add to dashboard Cite

Among cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO and mtDNAcn in a population of 389 coronary artery disease (CAD) patients and 151 healthy controls, in association with established risk factors for CVD (gender, age, hypertension, smoking, diabetes, glomerular filtration rate (GFR)). MtDNAcn was significantly lower in CAD patients and in hypertensive subjects; it correlates with GFR and TMA, but not with TMAO. A biomarker including mtDNAcn, gender, and hypertension (but neither TMA nor TMAO) emerged as a good predictor of CAD. Our findings support the usage of mtDNAcn as a plastic biomarker to monitor the exposure to risk factors and the efficacy of preventive interventions for a personalized CAD risk reduction.Highlights-mtDNAcn measured in whole blood is associated to the cardiovascular health status in humans;-mtDNAcn is reduced in CAD and hypertension, and inversely correlates with GFR;-mtDNA, gender and hypertension together represent a good predictive biomarker for CAD;-TMA metabolism is different in healthy and CAD subjects;-TMA and TMAO are not good predictors of CAD.

show abstract

Section: Discussionmentioning

confidence: 64%

Mitochondrial DNA copy number and trimethylamine levels in the blood: new insights on cardiovascular disease biomarkers

Bordoni

Petracci

Pelikant‐Małecka

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Some studies reported that fast eGFR decliners are at high risk for CV disease [14][15][16] . In the present study, there was no association between fast eGFR decliners and CV end-points, except for the renal end-point.…”

Section: Discussionmentioning

confidence: 99%

One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients

Meguro

Inaishi

Sato

et al. 2020

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction As estimated glomerular filtration rate (eGFR) progression might correlate with cardiovascular prognosis, the correlation between 1‐year decline in eGFR and cardiovascular incidences and renal outcome was investigated. Materials and Methods The 1‐year percentage decline in eGFR at the first observation year was calculated in a cohort of the standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) trial participants. The primary end‐point was the composite cardiovascular end‐point including the renal end‐point. The associations between the incidence of each end‐point and clinical markers were analyzed using the Cox proportional hazards regression model. Results A total of 4,461 patients were analyzed. The mean observation period was 765.3 ± 363.1 days. The best cut‐off value of 1‐year eGFR decline was 0.099 in the first year for renal end‐point prediction by receiver operating characteristic curve analysis. The area under the curve of the model including the 1‐year eGFR decline of the first year was significantly larger than the model without it (0.943, 95% confidence interval 0.915–0.971 to 0.967, 95% confidence interval 0.950–0.983, P = 0.019). Primary end‐point incidences and the renal end‐point were much higher in rapid eGFR decliners compared with non‐decliners (P < 0.0001). The cardiovascular end‐point incidence, except for the renal end‐point, was not different between the groups. According to Cox regression analysis, 1‐year eGFR decline during the first year was a significant risk factor for the end‐points, including the renal end‐point, independent of albuminuria and eGFR at baseline. Conclusions The 1‐year eGFR decline rate provided useful information for cardiovascular end‐point predictions, including the renal end‐point, in addition to the conventional risk factors.

show abstract

“…Reductions in eGFR even measured once has been shown to be predictive of adverse events. 36 Recently, the International Society of Nephrology Working group accepted that a single GFR<60 mL/min/1.73 m 2 may be used to evaluate the risks of developing CKD in epidemiological studies, because the costs of repeating creatinine measurements are often too high to be practical. 37 As a sensitivity analysis, we also evaluated the risk of SES factors on incident CKD in which GFR<60 mL/min/1.73 m 2 was confirmed by a repeat measurement 5 years later.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of socioeconomic status on the incidence of decreased glomerular filtration rate in a Southeast Asian cohort

Kitiyakara

Saranburut²,

Thongmung

et al. 2020

J Epidemiol Community Health

View full text Add to dashboard Cite

BackgroundThere is limited information on the role of low socioeconomic status (SES) in the development of new chronic kidney disease (CKD) in the general population, especially from developing countries. This study will test the hypothesis that low SES increases the risk of incidence of decreased glomerular filtration rate (GFR, used as an estimate for CKD) in a Thai worker cohort.MethodIn this prospective, longitudinal observational study, we evaluated the association of income and educational attainment on incident decreased GFR (iGFR <60 mL/min/1.73 m2) over a 27-year period in employees of Electricity Generating Authority of Thailand. In 1985, subjects participated in a health survey and were re-examined in 1997, 2002, 2007 and 2012. Education was classified into three categories: low, 0–8th grade; medium, 9–12th grade; and high, >12th grade. Income was categorised as follows: low <10 000 Thai Baht (THB)/month; medium, 10 000–20 000 THB/month; and high, >20 000 THB/month. HRs of iGFR<60 mL/min/1.73 m2 were estimated using Cox interval-censored models with high income or education as the reference groups after adjustments for clinical risk factors.ResultsParticipants (n=3334) were followed for 23 (15, 27) years. When evaluated separately, both education and income were risk factors for iGFR<60 mL/min/1.73 m2 (adjusted HR education: medium—1.26 (95% CI 1.13 to1.42) and low—1.57 (95% CI 1.36 to 1.81) and adjusted HR income: medium—1.21 (95% CI 0.97 to 1.50) and low—1.47 (95% CI 1.18 to 1.82)). When both income and education were included together, low and medium education remained independently associated with iGFR<60 mL/min/1.73 m2.ConclusionsLow education was independently associated with increased risk of decreased GFR in a Thai worker population. Strategies to identify risk factors among low SES may be useful to prevent early CKD.

show abstract

Change of Kidney Function Is Associated With All‐Cause Mortality and Cardiovascular Diseases: Results From the Kailuan Study

Cited by 40 publications

References 29 publications

Mitochondrial DNA copy number and trimethylamine levels in the blood: new insights on cardiovascular disease biomarkers

Mitochondrial DNA copy number and trimethylamine levels in the blood: new insights on cardiovascular disease biomarkers

One‐year estimated glomerular filtration rate decline as a risk factor of cardiovascular and renal end‐points in high‐risk Japanese patients

Long-term effects of socioeconomic status on the incidence of decreased glomerular filtration rate in a Southeast Asian cohort

Contact Info

Product

Resources

About