Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity

Molnár, Ágnes; Szentpéteri, Anita; Lőrincz, Hajnalka; Serés, I.; Harangi, Mariann; Balogh, Zoltán; Kempler, Péter; Paragh, György; Sztanek, Ferenc

doi:10.31083/j.rcm2305160

Cited by 4 publications

(3 citation statements)

References 45 publications

(58 reference statements)

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“…Interventional studies showed that physical activity significantly improves circulating FGF21. For instance, in obese type 2 diabetic patients with peripheral neuropathy (BMI: 31.6 ± 3.9 kg/m 2 ), 6 weeks of moderately intensive physical activity increased serum FGF21 [ 135 ]. In this study, the change in FGF21 negatively correlated with changes in BMI, improvement of current perception threshold value and TNFα levels, while there was a positive correlation between change of FGF21 and adiponectin.…”

Section: Role Of Novel Hepatokines and Gastrointestinal Hormones In N...mentioning

confidence: 99%

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

et al. 2023

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Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia. Formerly, several physiological roles of organokines, including adipokines, hepatokines, myokines and gut hormones have been described in obesity, especially in the regulation of glucose and lipid metabolism, insulin sensitivity, oxidative stress, and low-grade inflammation. The canonical effect of these biologically active peptides and proteins may serve as an intermediate regulatory level that connects the central nervous system and the endocrine, autocrine, and paracrine actions of organs responsible for metabolic and inflammatory processes. Better understanding of the function of this delicately tuned network may provide an explanation for the wide range of obesity phenotypes with remarkable inter-individual differences regarding comorbidities and therapeutic responses. The aim of this review is to demonstrate the role of organokines in the lipid and glucose metabolism focusing on the obese non-diabetic subgroup. We also discuss the latest findings about sarcopenic obesity, which has recently become one of the most relevant metabolic disturbances in the aging population.

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Section: Role Of Novel Hepatokines and Gastrointestinal Hormones In N...mentioning

confidence: 99%

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

et al. 2023

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“…Two studies found that irisin levels increased with 12 weeks of moderate-intensity exercise 3 times a week and 3 weeks of moderate- or high-intensity exercise once a week [25, 33]. One found an increase in FGF21 levels at low to moderate intensity 3 times per week for 6 weeks [30].…”

Section: Resultsmentioning

confidence: 99%

“…One found an increase in FGF21 levels at low to moderate intensity 3 times per week for 6 weeks [30]. RE benefits the expression of some myokines, such as BDNF, irisin, IGF-1, and CATB.…”

Section: Effectivenessmentioning

confidence: 99%

Exercise Regulates Myokines in Aging-Related Diseases through Muscle-Brain Crosstalk

Wang,

Liang,

et al. 2023

Gerontology

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Background: The related functions of skeletal muscle and brain decrease significantly with age, and muscle-brain-related diseases are primarily associated with each other. Exercise can promote the secretion of myokines in skeletal muscle, showing a beneficial effect on the function of both, reflecting muscle-brain crosstalk. However, the key mechanism of action of exercise-regulated myokines in muscle-brain diseases remains unclear. Summary: This review is intended to sort out and explore the key mechanism of the effect of exercise regulatory myokines on muscle-brain diseases through summarizing the relevant literature on the level of motor regulatory myokines in recent years and pay special attention to the impact of exercise type, intensity, and duration on myokine expression levels. Key Messages: The mechanism by which exercise regulates myokine levels in muscle-brain diseases is explained, and an effective exercise prescription for myokine expression that is more suitable for the elderly based on relevant literature is proposed. This work may hold certain value for subsequent exercise treatment of chronic diseases in the elderly and for further research on muscle-brain crosstalk.

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Apoptotic and Proinflammatory Processes Estimation in Patients With Diabetic Neuropathy

Obraztsova,

Popov,

Verevkin

et al. 2024

Problems Bio Med Pharm Chem

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Relevance. In many countries plants have long been used in folk medicine as a source of medicines, as they are well tolerated, gradual development of therapeutic effect and a mild effect on the body. Due to these features such medicines are being safely used in the treatment and prevention of exacerbations of chronic diseases: of cardiovascular system, respiratory system, digestive system, pathologies of the urinary tract, etc., and also as a rehabilitation therapy after past diseases. The purpose of the study is to systematize and generalize the data of world literature concerning the general health-improving and tonic properties study of plants growing in the Republic of Buryatia. Material and methods. In this work used publication materials from the PubMed and е-library databases, search.rsl. The keyword search: restorative, tonic effect, herbal medicines, medicinal plants of Buryatia, biologically active substances, Astragalus membranaceus, Saposhnikovia divaricatа, Scutellaria baicalensis, Sedum roseum, Crataegus sangunea. The survey comprises the data of foreign and national articles, published on the topic during last 20 years. Conclusions. All the plants listed in this review are used for thousands of years in the Tibetan medicine. Based on the analysis of the presented literature data, their range of medicinal use is much wider, then the applications in modern clinical practice. The information reported in this review may be the basis for the development of new herbal medicines, including officinal mixture, with specified pharmacological properties.

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Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity

Cited by 4 publications

References 45 publications

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

Exercise Regulates Myokines in Aging-Related Diseases through Muscle-Brain Crosstalk

Apoptotic and Proinflammatory Processes Estimation in Patients With Diabetic Neuropathy

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