Change of Choroidal Volume in Untreated Central Serous Chorioretinopathy

Pertl, Laura; Haas, Anton; Hausberger, Silke; Pichler, Tamara; Rabensteiner, Dieter Franz; Seidel, Gerald; Malle, Eva Maria; Weger, Martin

doi:10.1097/iae.0000000000001408

Cited by 13 publications

(6 citation statements)

References 20 publications

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“…Moreover, eyes with higher baseline choroidal volume also responded better with more reduction in SRF. 43 …”

Section: Imaging Parametersmentioning

confidence: 99%

“…[36][37][38][39][40][41][42] Choroidal volume. Pertl and colleagues 43 showed that in eyes with treatment-naïve CSCR, changes in CT and volume correlated with changes in subretinal fluid (SRF). Moreover, eyes with higher baseline choroidal volume also responded better with more reduction in SRF.…”

Section: Octmentioning

confidence: 99%

“…Moreover, eyes with higher baseline choroidal volume also responded better with more reduction in SRF. 43 Large and medium choroidal vessel layer thickness. Large choroidal vessels comprise a significant portion (up to 70%) of overall CT. 44 CSCR forms one of the disease entities in pachychoroid spectrum disorders and is characterized by thickened choroid and enlarged large choroidal vessels with compressed inner choroidal layers.…”

Section: Octmentioning

confidence: 99%

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Biomarkers for central serous chorioretinopathy

et al. 2020

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Central serous chorioretinopathy (CSCR) is a common chorioretinal disease characterized by serous retinal detachment that most commonly involves the macular region. Although the natural history of the acute form shows a self-limiting course, a significant number of patients suffer from recurrent episodes leading to chronic disease, often leaving patients with residual visual impairment. Visual morbidity is often worsened by a delay in the diagnosis due to the incorrect understanding of the particular biomarkers of the disease. The aim of this review is to provide clinical understanding of the biomarkers of CSCR with an emphasis on the most recent findings in patient demographics, risk factors, clinical imaging findings, and management options. Patients with these biomarkers, age 30–44 years, male gender, increased stress levels, hypercortisolism (endogenous and exogenous exposures), sleep disturbance, pregnancy, and genetic predisposition have increased susceptibility to CSCR. Also, biomarkers on optical coherence tomography (OCT) such as choroidal thickness (CT) and choroidal vascularity index (CVI) showed good diagnostic and prognostic significance in the management of CSCR. There are nonspecific features of CSCR on OCT and OCT angiography such as choroidal neovascularization, photoreceptor alteration/cone density loss, and flat irregular pigment epithelium detachment. We described rare complications of CSCR such as cystoid macular edema (CME) and cystoid macular degeneration (CMD). Patients with CME recovered some vision when treated with anti-vascular endothelial growth factors (anti-VEGFs). Patients with CMD had irreversible macular damage even after treatment with anti-VEGFs.

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“…Moreover, eyes with higher baseline choroidal volume also responded better with more reduction in SRF. 43 …”

Section: Imaging Parametersmentioning

confidence: 99%

Section: Octmentioning

confidence: 99%

Section: Octmentioning

confidence: 99%

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Biomarkers for central serous chorioretinopathy

et al. 2020

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Section: Introductionmentioning

confidence: 99%

“…Recently, SDOCT and OCT Angiography (OCTA) are allowing for new insights in the investigation of vascular and circulatory conditions in different chorioretinal disorders, including CSC [ 9 , 17 , 18 , 19 ]. In particular, OCTA is a dye-free technique that is able to analyze separately the different retinal vascular layers, the CC, and possible associated neovascular lesions [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Choroidal Structure after Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Alovisi

Piccolino²,

Nassisi

et al. 2020

JCM

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The study aims to analyze the changes produced by half-dose photodynamic therapy (HD-PDT) in the choroid of eyes with chronic central serous chorioretinopathy (CSC) applying the binarization method to spectral domain optical coherence tomography (SDOCT) and OCT Angiography (OCTA) images. SDOCT and OCTA were performed before, one hour, one week, and one month after HD-PDT. Binarization with a modified Niblack method and analysis by ImageJ were applied. An average ratio between luminal part and total structure was calculated. Twenty-two eyes of 21 patients (20 male and 1 female; mean age 54.8 years) were enrolled. A statistically significant reduction of the central choroidal thickness was observed one week (from 407 µm to 362 µm, p = 0.034) and one month (from 407 µm to 341.5 µm, p = 0.0004) after HD-PDT. The baseline average ratio between luminal part and total structure was 33.4% in SDOCT, and 61.1% in OCTA. These values were 35.3% and 61% one hour, 33.9% and 60.4% one week, and 34.5% and 60.6% one month after HD-PDT, respectively. Overall, PDT seems to produce short-term changes on the luminal component of both choriocapillaris and choroid, which return to baseline status after one month from treatment. However, choroid stays significantly thinner after one month, with both luminal and interstitial components significantly reduced.

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