Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study

Jensen, Britt W.; Bjerregaard, Lise G.; Ängquist, Lars; Gögenur, Ismail; Renehan, Andrew G.; Osler, Merete; Sørensen, Thorkild I A; Baker, Jennifer L.

doi:10.1038/s41366-018-0109-y

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…Other studies reported absence of a significant association between childhood BMI and colon cancer, but these studies were not adequately powered to detect such an association (10,11,19), or may have been hampered by the use of self-reported childhood body size (20,21). Very recently, a follow-up of the Danish study reported that overweight at age 7 or 13 was associated with increased risk of adult colon cancer if the overweight status was maintained until young adulthood, but not if the overweight status was normalized in adulthood (8). Adjusted HRs for colon cancer in relation to childhood overweight stratified by the median of pubertal BMI change.…”

Section: Discussionmentioning

confidence: 99%

“…Modifiable risk factors for colorectal cancer include physical inactivity, a high calorie/low fiber diet, high body mass index (BMI), excessive alcohol consumption, and smoking (3). A high BMI at different time points from young adult age to old age has been reported to increase the risk of colorectal cancer (4)(5)(6)(7)(8). Evidence of an association between high BMI in childhood and increased risk of colon but not rectal cancer was recently presented in a well-powered Danish study (9), but other reports have been unable to detect such an association (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Childhood Body Mass Index Is Associated with Risk of Adult Colon Cancer in Men: An Association Modulated by Pubertal Change in Body Mass Index

Célind

Ohlsson

Bygdell

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The relative contribution of childhood and pubertal body mass index (BMI) for the risk of adult colorectal cancer is not known. The aim of this study was to evaluate the independent associations for childhood BMI and pubertal BMI change with risk of colorectal cancer in men.Methods: We included 37,663 men born in 1946 to 1961 who had weight and height measured at 8 (childhood) and 20 (young adult age) years of age available from the BMI Epidemiology Study. Information on colorectal cancer was retrieved from the Swedish National Patient Register (257 cases of colon cancer and 159 cases of rectal cancer).Results: Childhood BMI at 8 years of age [HR, 1.19 per SD increase; 95% confidence interval (CI), 1.06-1.33], but not pubertal BMI change (HR, 1.02; 95% CI, 0.90-1.15), was associated with increased risk of colon cancer. Due to a significant interaction between childhood BMI and pubertal BMI change (P < 0.001), we stratified the analyses according to the median of pubertal BMI change. Childhood BMI was associated with risk of colon cancer in individuals with a pubertal BMI change above, but not below, the median (above: HR ¼ 1.48, 95% CI, 1.26-1.74; below: HR ¼ 0.95, 95% CI, 0.80-1.12). Neither childhood BMI nor pubertal BMI change was associated with rectal cancer.Conclusions: High childhood BMI was associated with increased risk of colon cancer only if it was followed by a pubertal BMI increase above the median.Impact: Further studies should evaluate prepubertal childhood BMI in relation to pubertal BMI change and BMI in middle age for the risk of colon cancer. NOTE: HRs for rectal cancer (n ¼ 159) according to anthropometric variables were calculated using Cox proportional hazards regression. Childhood refers to 8 years of age. Young adult BMI refers to 20 years of age. Pubertal BMI change is the change in BMI between 8 and 20 years of age. Adult height refers to the last recorded height after 17.5 years of age. The model is adjusted for birth year and country of birth. Total cohort N ¼ 37,663. Conception and design: J. C elind, C. Ohlsson, M. Bygdell, J.M. Kindblom Development of methodology: J. C elind, C. Ohlsson, M. Bygdell, J.M. Kindblom Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): J. C elind, M. Bygdell, J.M. Kindblom Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): J. C elind, C. Ohlsson, M. Nethander, J.M. Kindblom Writing, review, and/or revision of the manuscript: J. C elind, C. Ohlsson, M. Bygdell, M. Nethander, J.M. Kindblom C elind et al.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Childhood Body Mass Index Is Associated with Risk of Adult Colon Cancer in Men: An Association Modulated by Pubertal Change in Body Mass Index

Célind

Ohlsson

Bygdell

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Especially the increase in the CRC incidence is considered a consequence of the modern life-style and is associated with calorically excessive high-fat/low-fiber diet, consumption of refined products, lack of physical activity, and obesity [3,4]. This association seems to be stronger when childhood overweight persists into early adulthood than when the overweight disappears before early adulthood or develop after childhood [5].…”

Section: Introductionmentioning

confidence: 99%

The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development

Campisciano

Manzini

Delbue³

et al. 2020

Microorganisms

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An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation.

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“…Once considered an issue of resource rich nations, it is estimated that 1.9 billion adults globally are overweight of which nearly 30% are considered obese [2]. A complex metabolic disorder, obesity is associated with a multitude of comorbidities such as hypertension, cardiovascular disease, obstructive sleep apnea, certain malignancies, and an increase in all-cause mortality [3][4][5][6][7]. Indeed, the US national medical expenditure devoted to treating obesity and the aforementioned comorbidities have increased nearly 29% from 2001 to 2015 [8].…”

Section: Introductionmentioning

confidence: 99%

Endoscopic therapeutic interventions for management of postoperative bariatric surgery complications

Westerveld

Sharaiha

2020

Techniques and Innovations in Gastrointestinal Endoscopy

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Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study

Abstract: Childhood overweight that persists into early adulthood is associated with an increased risk of colon cancer, whereas overweight that disappears before early adulthood or developed after childhood is not.

Cited by 17 publications

References 25 publications

Childhood Body Mass Index Is Associated with Risk of Adult Colon Cancer in Men: An Association Modulated by Pubertal Change in Body Mass Index

Childhood Body Mass Index Is Associated with Risk of Adult Colon Cancer in Men: An Association Modulated by Pubertal Change in Body Mass Index

The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development

Endoscopic therapeutic interventions for management of postoperative bariatric surgery complications

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