Change In TXB2, MDA And AMP Levels During Artificial Pancreas Treatment On Diabetic Patients

Abstract

A study carried out on 9 insulin-dependent diabetic patients undergoing continuous blood glucose control by means of ex-vivo insulin injection (artificial pancreas - Biostator) has revealed : a relationship between the synthetic capacity of TXA2 (proaggregating molecule) by the platelet and the blood glucose level prior to feed back control. Concurrently, an identical relationship is observed in the case of platelet AMPc levels.After 24 hours of artificial pancreas treatment, it is noted that the greater the effectiveness of the treatment, the greater the increase in the synthetic capacity of TXA2. This observation is confirmed after 48 hours of treatment.Further, the relationship between MDA and Thromboxane B2 synthetized from the same precursory molecules is reversed during treatment.On the basis of these results we may assume that there is a disturbance in the regulation mechanisms of platelet synthesis during diabetes, but that these mechanisms are parthy reversible after artificial pancreas treatment.