Change in tropism upon immune escape by human immunodeficiency virus

McKnight, Áine; Weiss, Robin A.; Shotton, C; Takeuchi, Yasuhiro; Hoshino, Hiroo; Clapham, Paul R.

doi:10.1128/jvi.69.5.3167-3170.1995

Cited by 82 publications

(29 citation statements)

References 41 publications

(44 reference statements)

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“…Viral escape by point mutation of the V3 region also occurs to some degree, but the consistent number of residues that comprise HIV-1 V3 probably reflects functional constraints that are related to the role of V3 in co-receptor binding 39 . This is consistent with a report showing that changes in V3-directed neutralization sensitivity are associated with changes in co-receptor usage 40 . of relevance to this Review, similar alterations in neutralization sensitivity may occur for influenza variants that use alternative sialic acid linkages for entry.…”

Section: Fab Fragmentsupporting

confidence: 93%

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

et al. 2008

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The ability to elicit broadly neutralizing antibody responses against HIV-1 is a crucial goal for a prophylactic HIV-1 vaccine. Here, we discuss the difficulties of achieving broad HIV-1 neutralization in the context of both the effective annual human influenza virus vaccine and the need to develop a pandemic influenza vaccine. Immunogen-design strategies are underway to target functionally conserved regions of the HIV-1 envelope glycoproteins, and similar strategies might be applicable to pandemic influenza virus vaccine development. Efforts to develop broadly neutralizing vaccines against either HIV-1 or influenza virus might establish a paradigm for future vaccines against highly variable pathogens.

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Section: Fab Fragmentsupporting

confidence: 93%

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

et al. 2008

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“…Previous investigations demonstrated the presence of neutralizing antibodies in Ch-No but as with HIV-1 infection in humans [Bradney et al, 1999], this response gradually loses its speci®city towards the newly emerging SIVcpz-ant variants . Escape from the host neutralization response was not associated with alterations in the amino acid sequence of the V3 region in contrast to the situation described for HIV-1 in humans [Javaherian et al, 1986;Shioda et al, 1994;McKnight et al, 1995;Michael et al, 1996]. Rather, the neutralization speci®cities of the different isolates correlated with amino acid changes in the V1, V2, C3, and the V4 regions [Nyambi et al, 1997].…”

Section: Introductioncontrasting

confidence: 54%

Genetic variability of the V1 and V2 env domains of SIVcpz‐ant and neutralization pattern of plasma viruses in a chimpanzee infected naturally

Ondoa¹,

Davis²,

Willems³

et al. 2001

Journal of Medical Virology

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Specific neutralizing epitope changes have been observed in a chimpanzee infected naturally with SIVcpz, which differ from HIV-1 infecting humans. To characterize further these changes, a longitudinal study of env genomic sequence variation of SIVcpz-ant isolates was undertaken in this animal. The V1 and V2 regions of the env were determined to arise from specific recombination events. To determine whether recombination of the V1 and V2 domains was possibly associated with the emergence of neutralization escape viruses, envelope sequences and gene length polymorphisms from PBMC and plasma viral variants were studied over a 7-year period. PBMCs and plasma-associated infectious virus titers as well as plasma RNA viral loads were monitored longitudinally. The first 5 viruses isolated from the plasma were found to be neutralization escape variants. Sequence analysis of their V1 and the V2 regions indicated that a 20 amino acid stretch of the V1 region had undergone recombination and was also associated with the emergence of isolates eliciting strong neutralization responses. These findings support the hypothesis that recombination of the V1 and V2 regions of the envelope play a role in neutralization escape of SIVcpz in chimpanzees infected naturally. Furthermore, the data confirm that the neutralizing antibody response plays an important role in the decline of plasma infectious virus titers in HIV-1 related SIVcpz nonpathogenic infection.

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“…It has recently been shown that sequences inside the V3 loop known to influence tropism (17,21,44,56,61,75,80,85,87) and post-CD4 binding events (7,40,45,64) also influence coreceptor usage (22,33,67), formation of the CD4-CCR-5-gp120 ternary complex (81,88), and sensitivity to ␤-chemokine-mediated inhibition of entry (27,46). The V3 loop is therefore a candidate region for interaction with CCR-5 but is probably not the only Env region involved.…”

Section: Discussionmentioning

confidence: 99%

“…All the HIV-1 isolates used in this study have been described previously. LAI (82) is a TCLA strain, and GUN-1 (80) is also TCLA but dual tropic, as it can also infect macrophages (56,77). 89.6, a gift from R. Collman (University of Pennsylvania, Philadelphia), is a primary HIV-1 strain that infects macrophages and certain CD4 ϩ T-cell lines and is therefore also dual tropic (28).…”

Section: Cells and Viruses Ccc-cd4 Cells Are Cat Kidney Cells Stablymentioning

confidence: 99%

Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion

Picard

Simmons

Power

et al. 1997

J Virol

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117

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Human immunodeficiency virus type 1 (HIV-1) entry is governed by the interaction of the viral envelope glycoprotein (Env) with its receptor. The HIV-1 receptor is composed of two molecules, the CD4 binding receptor and a coreceptor. The seven-membrane-spanning chemokine receptor CCR-5 is one of the coreceptors used by primary isolates of HIV-1. We demonstrate that the mouse homolog of CCR-5 (mCCR-5) does not function as an HIV-1 coreceptor. A set of chimeras of human CCR-5 and mCCR-5 was studied for Env-induced cell fusion and HIV-1 infection. Using the HIV-1 ADA envelope glycoprotein in a syncytium formation assay, we show that replacement of any fragment containing extracellular domains of mCCR-5 by its human counterparts is sufficient to allow Env-induced fusion. Conversely, replacement of any fragment containing human extracellular domains by its murine counterpart did not lead to coreceptor function loss. These results show that several domains of CCR-5 participate in coreceptor function. In addition, using a panel of primary nonsyncytium-inducing and syncytium-inducing isolates that use CCR-5 or both CXCR-4 and CCR-5 as coreceptors, we show that the latter dual-tropic isolates are less tolerant to changes in CCR-5 than strains with a more restricted coreceptor use. Thus, different strains are likely to have different ways of interacting with the CCR-5 coreceptor.

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Change in tropism upon immune escape by human immunodeficiency virus

Cited by 82 publications

References 41 publications

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus

Genetic variability of the V1 and V2 env domains of SIVcpz‐ant and neutralization pattern of plasma viruses in a chimpanzee infected naturally

Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion

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