Change in the stability of tendon collagen during ageing in the reptile, Calotes versicolor. A brief note

Panigrahy, G.K.; Patnaik, B.K.

doi:10.1016/0047-6374(76)90042-7

Cited by 10 publications

(5 citation statements)

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“…A similar trend has been reported in the case of tendon of rat (. Schaub, 1964b) and Calotes (Panigraphy and Patnaik, 1976). The present results strengthen the suggestion of Hamlin and Kohn (1972) that an increase in the resistance of collagen to collagenase digestion with advance in age could be a parameter to determine the biological age of an animal.…”

Section: Resultssupporting

confidence: 77%

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Age-Related Changes in Rat Muscle Collagen

Mohan

Radha²

1980

Gerontology

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Age-related studies of collagen in slow, fast and cardiac muscle of the rat indicate that different fractions of collagen as well as total collagen content vary with age and type of muscle. The total collagen level increases by 30% in slow, 40% in fast and 50% in cardiac muscle as age advances from 5 to 25 months. Collagen of the muscles of old animals is less susceptible to the collagen-degrading enzyme when compared to the young, and the activity of the enzyme decreases significantly with age. The decrease in (1) the solubility of collagen; (2) the amount of hydroxyproline released at 65°C, and (3) the increase in the resistance of collagen to the degrading enzyme seen with aging, indicates that the stability of collagen increases in these muscles with aging. Results of the study of age-related changes of different fractions of collagen of slow, fast and cardiac muscle of the rat are presented in this paper.

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Section: Resultssupporting

confidence: 77%

“…3) and total ( fig. 4) 1962; Heikkinen and Kulonen, 1968;Tsurufuji and Ohuchi, 1968), rabbit (Nageotte and Guyon, 1934;Nimni et al, 1965), tendon of rat ( Verzar, 1960;Everitt et al, 1970) and lizard (Panigraphy and Patnaik, 1976). Figure 5 shows the age-related decrease in the amount of free hydroxy proline released at collagen level.…”

Section: Resultsmentioning

confidence: 99%

Age-Related Changes in Rat Muscle Collagen

Mohan

Radha²

1980

Gerontology

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“…In various tissues of garden liz ards, the solubilities of collagen in salt, acid and Ringer media revealed a decline during embryonic growth [92], postnatal growth and ageing [9,37,[93][94][95] (table 10). Aged collagen from tendon is less susceptile to collagenase digestion [96]. All these findings confirm that, as in mammals, the intra-and intermolecular cross-links of collagen increase with age in various tissues of garden lizards, thereby pro viding support to the cross-linking theory of ageing [90] and the concept of commonality of a basic mechanism of ageing processes in vertebrates.…”

Section: Characteristics O F Certain Proteinssupporting

confidence: 72%

Ageing in Reptiles

Patnaik¹

1994

Gerontology

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Like in fishes, the reptiles appear to show three types of senescence. The African skink, Mabuya buettneri, shows rapid senescence similar to death at mating observed in Salmon and marsupial mouse. Most of the lizards and snakes undergo gradual senescence comparable to the pattern exhibited by a majority of vertebrates. On the other hand, turtles, tortoises and crocodiles continue to grow throughout life and are thus credited with slow or negligible senescence. Evidences and mechanisms of rapid or negligible senescence in reptiles are still fragmentary and unclear. Findings in a few species of lizards (Calotes versicolor) and snakes (Natrix natrix) showing gradual senescence support the concept of commonalities in ageing phenomena in vertebrates. An age-related increase in the stability of collagen and accumulation of altered enzyme molecules, a decrease in metabolism and response to stress-enhanced anti-oxidative defence mechanisms and the nature of responses to hormones, restricted diet and lower environmental temperature corroborate the concept. On the other hand neither the increase in mortality rate and accumulation of lipofuscin nor the reproductive senility have been shown conclusively in ageing reptile populations. It is likely that there are multiple mechanisms of senescence in reptiles. Further studies on selected species from among the 6,000 living species are necessary to unravel the phenomena.

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“…But the fact that alloxan diabetes accelerates the ageing of collagen by inducing an increased number of cross-links needed support from tests other than the acid solubility test. Assessment of the rates of digestion of purified insoluble collagen by collagenase appears to be a suitable method which has earlier been used successfully to determine the chronological age of human subjects Kohn, 1971, 1972], es timate the stability of aged collagen [Panigrahy and Patnaik, 1976] and assess the sta bility of collagen in postmortem samples [Hall and Reed, 1973], In the present study, the same parameter is used to test the degree of stability of collagen from different tissues of alloxan-diabetic mice. …”

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confidence: 99%