Change in the emission saturation and kinetics of upconversion nanoparticles under different light irradiations

Bagheri, Niusha; Liu, Qingyun; Bergstrand, Jan; Pu, Rui; Zhan, Qiuqiang; Ara, M.H. Majles; Ågren, Hans; Liu, Haichun; Widengren, Jerker

doi:10.1016/j.optmat.2019.109389

Cited by 4 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventional UCNPs are mostly composed of an inorganic crystalline NaYF 4 matrix doped by two types of lanthanide ions, one acting as an activator and another acting as a sensitizer (Auzel, 2004). Due to a large absorption cross-section, Yb 3+ is typically used as a sensitizer responsible for the accumulation of excitation light energy and its transfer to the activator ion via non-radiative energy transfer (Bagheri et al, 2019). Yb 3+ matches several activator ions, such as Tm 3+ , Er 3+ , or Ho 3+ , and in combination with them generates upconversion luminescence after absorption of NIR light at 980 nm (Zhou et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

et al. 2020

View full text Add to dashboard Cite

4 :Nd 3+-PEG-RGDS nanoparticles on both Hep-G2 and HeLa cells was determined, confirming no adverse effect on their survival and proliferation. The interaction of the nanoparticles with Hep-G2 cells was monitored by confocal microscopy at both 808 and 980 nm excitation. The NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-RGDS nanoparticles were localized on the cell membranes due to specific binding of the RGDS peptide to integrins, in contrast to the NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-Alk particles, which were not engulfed by the cells. The NaYF 4 :Yb 3+ /Er 3+ @NaYF 4 :Nd 3+-PEG-RGDS nanoparticles thus appear to be promising as a new non-invasive probe for specific bioimaging of cells and tissues. This development makes the nanoparticles useful for diagnostic and/or, after immobilization of a bioactive compound, even theranostic applications in the treatment of various fatal diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Discriminating the wavelength of the incident light is very important for a multiband photodetector. From our previous studies, we realized that each UCNC constitutes a kinetic optical system formed by many coupled optical centers (lanthanide ions) that can have fingerprint responses to certain optical stimuli, e.g., excitation wavelength, excitation intensity, and excitation modulation 28 , 29 , 49 . Considering that the CSS UCNCs have different response speeds at different excitation wavelengths, rooted in differences of the photon upconversion pathways, we exploited the possibility of distinguishing excitation wavelengths using the UCNC’s response to the excitation modulation frequency, a Fourier transformation to time.…”

Section: Resultsmentioning

confidence: 99%

“…We designed and synthesized multi-wavelength responsive core-shell-shell (CSS)-structured UCNCs that emit visible light under excitation at 808, 980, or 1540 nm and constructed NIR PDs on top. Realizing that each UCNC constitutes an information-rich kinetic system exhibiting characteristic responses to optical signals in the temporal and frequency domains of different excitation wavelengths 28 , 29 , we exploited the possibility of separating the channels of multi-wavelength photodetection to implement selective detection. We proved that the modulation frequency response can be used to distinguish the detected wavelengths well.…”

Section: Introductionmentioning

confidence: 99%

Huge upconversion luminescence enhancement by a cascade optical field modulation strategy facilitating selective multispectral narrow-band near-infrared photodetection

Ding

et al. 2020

Light Sci Appl

Self Cite

View full text Add to dashboard Cite

Since selective detection of multiple narrow spectral bands in the near-infrared (NIR) region still poses a fundamental challenge, we have, in this work, developed NIR photodetectors (PDs) using photon upconversion nanocrystals (UCNCs) combined with perovskite films. To conquer the relatively high pumping threshold of UCNCs, we designed a novel cascade optical field modulation strategy to boost upconversion luminescence (UCL) by cascading the superlensing effect of dielectric microlens arrays and the plasmonic effect of gold nanorods, which readily leads to a UCL enhancement by more than four orders of magnitude under weak light irradiation. By accommodating multiple optically active lanthanide ions in a core-shell-shell hierarchical architecture, developed PDs on top of this structure can detect three well-separated narrow bands in the NIR region, i.e., those centered at 808, 980, and 1540 nm. Due to the large UCL enhancement, the obtained PDs demonstrate extremely high responsivities of 30.73, 23.15, and 12.20 A W−1 and detectivities of 5.36, 3.45, and 1.91 × 1011 Jones for 808, 980, and 1540 nm light detection, respectively, together with short response times in the range of 80–120 ms. Moreover, we demonstrate for the first time that the response to the excitation modulation frequency of a PD can be employed to discriminate the incident light wavelength. We believe that our work provides novel insight for developing NIR PDs and that it can spur the development of other applications using upconversion nanotechnology.

show abstract

“…[ 123 ] Other researchers have found that various factors may affect emission properties, including sample concentration, temperature, surface modification, excitation power, and the types of lanthanides and their compositional ratios. [ 61,124,125 ]…”

Section: Basic Concepts Of Upconversion Nanoparticlesmentioning

confidence: 99%

“…[31] However, the key difference between PET/SPECT and other imaging modalities previously discussed is PET/SPECT requires the attachment of a radioactive tracer to visualize the uptake of molecules of interest into a tissue, which may take additional preparation, but enables more accurate quantification of nanoparticles, especially in organs located deep inside the body. [231] For example, Kostiv et al published two papers on multimodal imaging with 125 I-labeled NaGdF 4 core nanoparticles and used a neridronate linker to attach 125 I to the UCNPs. These PEG-labeled UCNPs enabled unmodified trimodal imaging of CT, SPECT, and MRI and monitoring of UCNP biodistribution for up to 14 days following injection in mice.…”

Section: Applications Of Ucnps In Multimodal Bioimagingmentioning

confidence: 99%

Bioimaging with Upconversion Nanoparticles

Mettenbrink

Yang

Wilhelm

2022

Advanced Photonics Research

View full text Add to dashboard Cite

Bioimaging enables the spatiotemporal visualization of biological processes at various scales empowered by a range of different imaging modalities and contrast agents. Upconversion nanoparticles (UCNPs) represent a distinct type of such contrast agents with the potential to transform bioimaging due to their unique optical properties and functional design flexibilities. This review explores and discusses the opportunities, challenges, and limitations that UCNPs exhibit as bioimaging probes and highlights applications with spatial dimensions ranging from the single nanoparticle level to cellular, tissue, and whole animal imaging. Recent advancements in bioimaging applications enabled by UCNPs, including super‐resolution techniques and multimodal imaging methods are summarized, and a perspective on the future potential of UCNP‐based technologies in bioimaging research and clinical translation is provided. This review may provide a valuable resource for researchers interested in exploring and applying UCNP‐based bioimaging technologies.

show abstract

Change in the emission saturation and kinetics of upconversion nanoparticles under different light irradiations

Cited by 4 publications

References 53 publications

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

Monodisperse Core-Shell NaYF4:Yb3+/Er3+@NaYF4:Nd3+-PEG-GGGRGDSGGGY-NH2 Nanoparticles Excitable at 808 and 980 nm: Design, Surface Engineering, and Application in Life Sciences

Huge upconversion luminescence enhancement by a cascade optical field modulation strategy facilitating selective multispectral narrow-band near-infrared photodetection

Bioimaging with Upconversion Nanoparticles

Contact Info

Product

Resources

About