Change in the activity of cortical neurons under the influence of biogenic amines

Abstract

Under the conditions of extracellular recording of action potentials, the influence of proposed neuromediators on the structure of background impulse activity of neurons of various regions of the cerebral cortex was studied. Computer analysis of the statistical parameters of impulse flows revealed the presence of a fundamental difference between the effects of neuromediators of cortical and subcortical origin. It was demonstrated that prolonged application of serotonin and noradrenalin evokes a change in structure of cortical neuron impulse activity more complex than the simple inhibition and excitation characteristic of acetylcholine or GABA. Different types were found of the reaction of neurons to the same monoaminergic stimulus, types whose characteristic feature is the dependence of the end result of the influence on the initial level of excitation in the neuron examined. The fundamental difference between the effects of preparations studied in the visual and sensorimotor regions of the cortex was not discovered. The data obtained are considered from the point of view of the modulating role of the biogenic amines in the regulation of the level of excitation of cerebral cortical neurons.

Précis of Neural organization: Structure, function, and dynamics

“…With NR, it tends to some intermediate excitation level, regardless of its initial level. These conclusions have been verified in experiments (Mamedov 1987;Zhadin 1987; involving a long-term increase in concentration of serotonin or norepinephrine in the intercellular medium with direct application of these monoamines to the neocortex. These patterns in neuronal activity occurred: serotonin induced the patterns typical of PR and norepinephrine of NR.…”

Cognitive incrementalism: The big issue

“…Olds used rather high intensity stimulation, hence they had no reliable way to localize nuclei as small as the raphe nuclei and locus coeruleus. These conclusions have been verified in experiments (Mamedov 1987;Zhadin 1987; involving a long-term increase in concentration of serotonin or norepinephrine in the intercellular medium with direct application of these monoamines to the neocortex. It was shown that under these conditions the neurons must manifest typical and well-distinguishable patterns of their activity.…”

Subchronic Amitriptyline Influences Open-field Behaviours and Spontaneous Working-memory in Healthy Mice

“…Amitriptyline prevents the uptake of norepinephrine and serotonin in adrenergic and serotonergic neuron by inhibiting the membrane pump mechanism responsible for amine uptake. This may result in the potentiation of neuronal response; largely because reuptake of these biogenic amines is crucial in the termination of neuronal impulses [7] Amitriptyline has also been reported to potentiate dopamine-induced hyperlocomotion [8], via its effects on dopamine receptors (D 2 /D 3 ) [8,9]. The interference with the reuptake of norepinephrine and/or serotonin is believed to underlie the antidepressant activity of amitriptyline.…”