Change in sexual activity after a cardiac event: the role of medications, comorbidity, and psychosocial factors

Steinke, Elaine E.; Mosack, Victoria; Hill, Twyla J.

doi:10.1016/j.apnr.2015.04.011

Cited by 25 publications

(15 citation statements)

References 19 publications

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“…We investigated the possible role of cardiac medication, but the only significant relationships were between erectile dysfunction and prescription of diuretics and statins. The association with diuretics has been observed in previous studies, 15 24 but the statin effect has not. Since we tested several aspects of sexual behaviour and many different medications, the two significant associations may be chance effects.…”

Section: Discussionmentioning

confidence: 58%

Sexual activity and concerns in people with coronary heart disease from a population-based study

Steptoe

Jackson

Wardle

2016

Heart

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Objective Sexual activity is a central component of intimate relationships, but sexual function may be impaired by coronary heart disease (CHD). There have been few representative population-based comparisons of sexual behaviour and concerns in people with and without CHD. We therefore investigated these issues in a large nationally representative sample of older people. Methods We analysed cross-sectional data from 2979 men and 3711 women aged 50 and older from the English Longitudinal Study of Ageing. Sexual behaviour and concerns were assessed by validated self-completion questionnaire and analyses were weighted for non-response. Covariates included age, partnerships status and comorbidities. Results There were 376 men and 279 women with CHD. Men with CHD were less likely to be sexually active (68.7% vs 80.0%, adjusted OR 0.62, 95% CI 0.47 to 0.81), thought less about sex (74.7% vs 81.9%, OR 0.72, CI 0.54 to 0.95), and reported more erectile difficulties (47.4% vs 38.1%, OR 1.46, CI 1.10 to 1.93) than men without CHD. Effects were more pronounced among those diagnosed within the past 4 years. Women diagnosed <4 years ago were also less likely to be sexually active (35.4% vs 55.6%, OR 0.44, CI 0.23 to 0.84). There were few differences in concerns about sexual activity. Cardiovascular medication showed weak associations with erectile dysfunction. Conclusions There is an association between CHD and sexual activity, particularly among men, but the impact of CHD is limited. More effective advice after diagnosis might reverse the reduction in sexual activity, leading to improved quality of life.

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Section: Discussionmentioning

confidence: 58%

Sexual activity and concerns in people with coronary heart disease from a population-based study

Steptoe

Jackson

Wardle

2016

Heart

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“…Furthermore, it was acknowledged in a systematic review [69] and the Third National Survey of Sexual Attitudes and Lifestyles [70] that hypertensive women exhibited higher prevalence of SD than normotensive women. A number of papers have identified that first and thirdgeneration beta-blockers as well as a whole host of antihypertensive drug classes are associated with decline in sexual function; however, it is not clear if SD precedes the antihypertensive treatment or occurs after [69,71,72]. Iatrogenic drugs are discussed in more detail below.…”

Section: Sd and Comorbiditiesmentioning

confidence: 99%

“…In women, the overarching question is whether SD precedes or results from antihypertensive therapy. A study of 211 hypertensive women found that SD was likely to be iatrogenic to antihypertensive medication [71]. The 2016 SPRINT trial showed that, while SD had a high prevalence among the sexually active participants, no particular class of antihypertensives had special impact on sexual function [161], and these findings were mirrored in a 2019 systematic review, where the authors found no difference between treatment with alpha-blockers, first and third-generation beta-blockers, calcium-channel blockers (CCBs), angiotensin-converting-enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or diuretics in increasing the risk of SD in women [69].…”

Section: Iatrogenic Sdmentioning

confidence: 99%

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

Chou

Kiebalo

Jagiello

et al. 2021

Life

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Patient survival continues to increase with the growing quality of dialysis and management of chronic kidney disease (CKD). As such, chronic therapy must include considerations of quality of life (QOL), and this includes the disproportionate prevalence of sexual dysfunction (SD) in this patient population. This review aims to describe the pathophysiological and the psychosocial causes of SD with regard to renal replacement therapy, particularly hemo- and peritoneal dialysis. The differences in its manifestation in men and women are compared, including hormonal imbalances—and therefore fertility, libido, and sexual satisfaction—the experience of depression and anxiety, and QOL. The impact of comorbidities and the iatrogenic causes of SD are described. This review also presents validated scales for screening and diagnosis of SD in CKD patients and outlines novel therapies and strategies for the effective management of SD. Increased prevalence of CKD invariably increases the number of patients with SD, and it is crucial for health care professional teams to become familiar with the clinical tools used to manage this sensitive and under-quantified field. As a known predictor of QOL, sexual function should become a point of focus in the pursuit of patient-centered care, particularly as we seek to achieve as “normal” a life as possible for individuals who receive dialysis.

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“…Diuretik loop ditemukan secara signifikan berkontribusi pada perubahan aktivitas seksual dan saat ini dilaporkan bahwa lebih banyak pasien yang menggunakan diuretik loop dibandingkan dengan tiazid dan diuretik hemat kalium. 17 Hasil penelitian Sarma AV tahun 2019 pada 692 pasien yang berusia 19-50 tahun, 451 laki-laki (69%) dilaporkan menikah, 21% pria melaporkan merokok sedangkan 46% melaporkan minum alkohol setidaknya sekali per minggu. Lebih dari 60% pasien kelebihan berat badan atau obesitas pada awal dengan median BMI berukuran 25,9 kg / m2 dan median DCCT / EDIC HbA1c adalah 7,9% (kisaran 4,4-13,9).…”

Section: Diuretikunclassified

Pengaruh Obat Antihipertensi terhadap Disfungsi Ereksi

Amrin

Tendean

Turalaki

2021

eBM

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Erectile dysfunction (ED) is a condition where intercourse is not interrupted due to the inability of the penis to achieve a penile erection. Drugs that can affect erectile dysfunction are drugs for hypertension therapy, namely diuretics and β-blockers, except for nebivolol and clonidine. The purpose of this study was to determine the effect of antihypertensive drugs on erectile dysfunction. This study was in the form of a literature review by searching data using three databases namely ScienceDirect, Pubmed and Google Scholar. The keywords used were antihypertensive drugs AND erectile dysfunction. After being selected based on inclusion and exclusion criteria, there were 12 literature consisting of 4 randomized controlled trials, 3 cross-sectional studies, 2 cohort studies and 1 case control study. The research shows that 3 out of 5 literature states that there is an effect of diuretic antihypertensive drugs on the occurrence of erectile dysfunction, while 6 out of 9 literature states that there is no effect of β-blocker antihypertensive drugs on the occurrence of erectile dysfunction. In conclusion, diuretic and β-blocker as antihypertensive drugs have an effect on erectile dysfunction. Diuretic antihypertensive drugs have more impact on erectile dysfunction compared to β-blocker antihypertensive drugs.Keywords: Antihypertensive drugs, erectile dysfunction Abstrak: Disfungsi ereksi (DE) adalah keadaan dimana hubungan seksual terganggu akibat ketidakmampuan penis dalam mencapai ereksi penis. Obat yang dapat mempengaruhi disfungsi ereksi yaitu obat untuk terapi hipertensi yaitu golongan diuretik dan golongan β-blocker kecuali nebivolol dan klonidin. Tujuan penelitian ini adalah untuk mengetahui pengaruh obat antihipertensi terhadap disfungsi ereksi. Penelitian ini dalam bentuk literature review dengan pencarian data menggunakan tiga database yaitu ScienceDirect, Pubmed dan Google Cendekia. Kata kunci yang digunakan yaitu obat antihipertensi DAN disfungsi ereksi. Setelah diseleksi berdasarkan kriteria inklusi dan eksklusi didapatkan 12 literatur yang terdiri dari 4 randomized controlled trial, 3 cross-sectional study, 2 cohort study dan 1 case control study. Dari penelitian menunjukan bahwa 3 dari 5 literatur menyebutkan terdapat pengaruh obat antihipertensi golongan diuretik terhadap terjadinya disfungsi ereksi, sedangkan 6 dari 9 literatur menyebutkan tidak terdapat pengaruh obat antihipertensi golongan β-blocker terhadap terjadinya disfungsi ereksi. Sebagai simpulan, obat antihipertensi golongan diuretik dan β-blocker memiliki pengaruh terhadap disfungsi ereksi. Obat antihipertensi golongan diuretik lebih berpengaruh terhadap disfungsi ereksi dibandingkan dengan obat antihipertensi golongan β-blocker.Kata Kunci: Obat antihipertensi, disfungsi ereksi

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Change in sexual activity after a cardiac event: the role of medications, comorbidity, and psychosocial factors

Cited by 25 publications

References 19 publications

Sexual activity and concerns in people with coronary heart disease from a population-based study

Sexual activity and concerns in people with coronary heart disease from a population-based study

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

Pengaruh Obat Antihipertensi terhadap Disfungsi Ereksi

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