Change in prevalence of atopic dermatitis between 1986 and 2001 among children

Stensen, Lise; Thomsen, Simon F.; Backer, Vibeke

doi:10.2500/aap.2008.29.3139

Cited by 44 publications

(23 citation statements)

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“…The 12-month prevalence of itchy flexural eczema in Seoul was significantly higher in 2008 than in 1995 and 2000, demonstrating that the prevalence of AD continues to increase [10,11]. This upward trend is more pronounced in industrialized countries [4,5,6,7,8]. Seoul underwent rapid industrialization in the 1960s, and children in the city have subsequently been exposed to an increasing array of environmental factors.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, AD is often the first symptom of allergic disease. The prevalence of AD has increased significantly over the last three decades, particularly in developed countries, and the disease currently affects around 20–30% of children [4,5,6,7,8]. Two Nationwide Studies of Asthma and Allergies in Korean Children have been conducted, the first in 1995 and the second in 2000.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Lee¹,

Seo²,

Kwon

et al. 2011

Int Arch Allergy Immunol

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“…Likewise, atopic dermatitis (AD) is a common disorder with a lifetime prevalence of 15-20% (1,2). Recent studies show increasing prevalence of asthma and AD in Western countries including Denmark (3)(4)(5). Hence, among Danish children, the self-reported number of children with asthma rose from 5.3% in 1986 to 11.7% in 2001 (6) and from 17.3% to 27.3% for AD during the same period (5).…”

mentioning

confidence: 99%

Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children – a prospective cohort study

Larsen¹,

Schlünssen²,

Christensen³

et al. 2014

Scand J Work Environ Health

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Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children -a prospective cohort study by Larsen AD, Schlünssen V, Christensen BH, Bonde JP, Obel C, Thulstrup AM, Hannerz H, Hougaard KS Literature suggests a relationship between maternal stress exposure and risk of asthma and atopic dermatitis (AD) among children; so far no studies have focused on maternal job strain. Based on the prospective Danish National Birth Cohort, results show: maternal exposure to high strain jobs was associated with AD, whereas active jobs were associated with asthma among 7-year old children. Affiliation 639Original article Scand J Work Environ Health. 2014;40(6):639-648. doi:10.5271/sjweh.3452 Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children -a prospective cohort study Objectives Few epidemiological studies have studied maternal stress exposure during pregnancy and odds of asthma and atopic dermatitis (AD) among offspring, and none have extended the focus to psychosocial job strain. The aim of this study was to assess the association between maternal job strain during pregnancy and asthma as well as AD among 7-year-old children. MethodsThe study is based on the Danish National Birth Cohort and includes prospective data from 32 104 pregnancies. Job strain was assessed early in pregnancy by use of two questions on demands and control. We categorized participants into four job strain categories: low strain (low demands, high control), active (high demands, high control), passive (low demands, low control), and high strain (high demands, low control). Information on asthma and AD until age seven was collected using maternal self-report. Multinomial logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (95% CI) adjusted for several covariates.Results Maternal exposure to self-reported high strain during pregnancy was associated with 15% higher odds of atopic dermatitis among 7-year-old children (OR adj 1.15, 95% CI 1.02-1.31). Furthermore, an association between the active jobs and asthma among 7-year-old children was found (OR adj 1.13, 95% CI 1.03-1.24). ConclusionMaternal exposure to high strain and active jobs during pregnancy was associated with asthma and atopic dermatitis among 7-year-old children.

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“…O ressecamento da pele está presente em muitas doenças cutâneas pruriginosas, como a xerose e a dermatite atópica (DA), a qual é, atualmente, a característica mais prevalente das condições que envolvem a pele seca e o prurido [6]. A DA é a condição inflamatória da pele de maior ocorrência durante a infância [7], e nas duas últi-mas décadas, a sua prevalência aumentou entre 18 % e 25 % em alguns países desenvolvidos [8]. A DA não é contagiosa e caracteriza-se , na sua fase aguda, por prurido intenso, exantema eritematoso, vesículas e edema, e liquenificação na fase crônica [7,9,10].…”

Section: Animalsunclassified

“…Skin dryness is present in many pruritic cutaneous diseases, such as xerosis and atopic dermatitis (AD), which is actually the most prevalent hallmark of these conditions involving dry skin and pruritus [6]. AD is the most common higher occurrence inflammatory skin condition during infancy and childhood [7] so that in the last two decades, its prevalence has increased between 18% and 25 % in some developed countries [8]. AD is noncontagious and characterized in acute phases by intense itching, erythematous rash, vesicles and oedema, and lichenification in chronic stages [7,9,10].…”

Section: Introductionmentioning

confidence: 99%

Atopic dermatitis-like disease in a rat model

Barcelos

Mello-Sampayo

Antoniazzi

et al. 2013

BBR

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217 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Atopic dermatitis-like disease in a rat model Modelo tipo de dermatite atópica em rato AbstractThe Atopic dermatitis (AD) is a most important topic in clinical dermatology. In fact, the pathogenesis of this chronic inflammatory skin disease, primarily characterized by pruritus and dry skin, is still far from being fully understood. To look further into this complex disease, male adult Wistar rats (n = 10) were used as a model where acetone (AA) acted as the active challenger in a 3-day treatment setting, and compared with water (AW). On day 3, one hour after the last treatment, the AA area exhibited higher transepidermal water loss (TEWL), capillary blood flow, and reduced hydration when compared to AW. The scratching behavior was markedly higher in the AA treated group (n = 5) than in the AW group (n = 5). These interesting results justify the application of this model as a clinical experimental tool for AD research.Keywords: atopic dermatitis; pathophysiology; animal model; inflammation, pruritus ResumoA dermatite atópica (DA) é um tema importante na dermatologia clínica. Na verdade, a patogénese dessa doença inflamatória crónica da pele, caracterizada principalmente por pele seca e prurido, ainda está longe de ser totalmente compreendida. A fim de saber mais acerca desta complexa doença, ratos Wistar machos e adultos (n = 10) foram utilizados como modelo animal, nos quais o tratamento com acetona (AA) foi comparado com o tratamento com água por 3 dias (AW). No dia 3, uma hora após o último tratamento, a AA mostrou maior perda transepidérmica de água (TEWL), fluxo sanguíneo capilar e reduzida hidratação quando comparada com AW. A análise comportamental mostrou que a acção de coçar foi marcadamente mais frequente no grupo AA (n = 5) quando comparado ao grupo AW (n = 5). Estes resultados justificam a implementação deste modelo animal como uma ferramenta experimental para investigação da AD.Palavras-chave: dermatite atópica, fisiopatologia, modelo animal, inflamação, prurido

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Change in prevalence of atopic dermatitis between 1986 and 2001 among children

Cited by 44 publications

References 0 publications

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Exposure to Gene-Environment Interactions before 1 Year of Age May Favor the Development of Atopic Dermatitis

Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children – a prospective cohort study

Atopic dermatitis-like disease in a rat model

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