Background: Systems to track fatal and non-fatal overdoses rely on medical services to provide information about overdoses, which only capture overdoses in which medical care is provided. In the state of Missouri, the Overdose Field Report (ODFR) is a community-based reporting system which allows medical and lay responders to report overdoses they have witnessed and/or responded to. By broadening the pool of overdose events which can be captured, it is possible to better describe the overdose crisis landscape and evaluate the effectiveness of overdose interventions.Objectives: To describe the characteristics of fatal and non-fatal overdoses reported to Missouri’s Overdose Field Report. Methods: This study used a descriptive epidemiological approach to examine the demographics and circumstances of overdoses reported to the ODFR. We also used a logistic regression to evaluate factors associated with overdose survival, and a Poisson regression to evaluate factors associated with the number of naloxone doses used during an overdose.Results: Between 2018 and 2022, 12,224 overdoses were reported through the ODFR, with a survival rate of 96% (n = 11,316). Our sample is 67% male (n = 8,161) and 78% were White (n = 9,308). Most events were reported by emergency response personnel (34%) and friends of the individuals who had overdosed (33%) and most overdoses came from the St. Louis Metro Area (71%). Fewer than 50% of responses indicated the individual who overdosed was transported to the hospital. Survival was associated with age, drug type, presence of fentanyl, type of naloxone being used, and the responder. The average number of doses of naloxone used was 1.75 and remained consistent over time. The number of doses was associated with the belief fentanyl was involved in the overdose was associated with more doses being used. Conclusion: Our study found that a centralized overdose reporting mechanism can provide useful information about non-fatal overdoses which may not be reported through existing syndromic surveillance systems. Our reporting form allowed us to develop a more comprehensive picture of the events surrounding non-fatal overdoses, including who responds, how much naloxone was used, and what drugs the respondent believed to be involved. Improved understanding of the overdose crisis requires more complete data collection methods and better engagement with a population that may be distrustful of researchers and medical personnel.