Change in Plasma Immunoreactive N-Terminus, C-Terminus, and 4,000-Dalton Midportion of Atrial Natriuretic Factor Prohormone with Hemodialysis

Winters, Chris J.; Vesely, David L.

doi:10.1159/000186371

Cited by 29 publications

(19 citation statements)

References 21 publications

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“…Decreased renal parenchyma functions results with decreased degradation of ANP and BNP and higher circulating concentrations of these peptides than the other diseases associated with intravascular overload [14]. A significant increase in ANP and BNP levels after the treatment was observed in this study between both the same and the different courses of the chemotherapy, compared with the control group.…”

Section: Discussionsupporting

confidence: 44%

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Natriuretic Peptides’ Role in Determining the Chemotherapy-Induced Nephrotoxicity and Their Value in Follow-Up

Erkurt

2012

World J Nephrol Urol

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Section: Discussionsupporting

confidence: 44%

“…The disease state associated with the highest intravascular overload is renal failure because of the reduction of GFR. Plasma levels of ANP and BNP are almost always raised in end stage renal disease patients undergoing hemodialysis and in the late predialysis stage [5,7,14]. Fluid removal by hemofiltration lowers the plasma ANP levels [7].…”

Section: Discussionmentioning

confidence: 99%

Natriuretic Peptides’ Role in Determining the Chemotherapy-Induced Nephrotoxicity and Their Value in Follow-Up

Erkurt

2012

World J Nephrol Urol

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“…Subjects with a creatinine level Ͼ1.5 mg/dL were excluded because vessel dilator increases in the circulation of humans with renal failure. 7,8 Likewise, vessel dilator increases in the circulation of persons with ascites, 9,10 so these subjects were excluded from the present study. None of the patients' prescribed medications were taken the day of the study.…”

Section: Chf Volunteersmentioning

confidence: 99%

Vessel Dilator Enhances Sodium and Water Excretion and Has Beneficial Hemodynamic Effects in Persons With Congestive Heart Failure

et al. 1998

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Background-Vessel dilator, a 37-amino acid peptide hormone synthesized in the heart, enhances urine flow 4-to 12-fold and sodium excretion 3-to 6-fold in healthy humans. The present investigation was designed to determine whether vessel dilator might have similar beneficial effects in persons with congestive heart failure (CHF). Methods and Results-Vessel dilator (100 ng/kg body weight per minute) given intravenously for 60 minutes to NYHA class III CHF subjects increased urine flow 2-to 13-fold, which was still increased (PϽ0.001) 3 hours after its infusion was stopped. Vessel dilator enhanced sodium excretion 3-to 4-fold in CHF subjects (PϽ0.01), which was still significantly (PϽ0.01) elevated 3 hours after infusion. Vessel dilator decreased systemic vascular resistance 24%, pulmonary vascular resistance 25%, pulmonary capillary wedge pressure 33%, and central venous pressure 27% while increasing cardiac output 34%, cardiac index 35%, and stroke volume index 24% without significantly affecting heart rate or pulmonary artery pressure in the CHF subjects. The control CHF patients did not have any changes in the above parameters. Conclusions-These results indicate that vessel dilator has significant beneficial diuretic, natriuretic, and hemodynamic properties in humans with congestive heart failure. (Circulation. 1998;98:323-329.)

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“…Although one would also expect both the N-terminus and C-terminus to be released simultaneously -as has been shown previously with other stimuli such as central hypervolemia in healthy volunteers [18] and by rapid ventricular cardiac pacing [28] -it is possible that with less severe abnormalities in sodium retention, only in creased N-terminal concentrations are detected because it accumulates in the circulation and is not degraded as rapidly as ANF (C-terminus). This is what happens in chronic renal failure where the N-terminus with its lon ger half-life accumulates (increases) in the circulation to a disproportionately greater extent than the C-terminus [12,29]. This formulation may explain why the N-terminus but not the C-terminus of the ANF prohormone is increased in the basal state of the cirrhotic individuals studied, i.e., the N-terminus accumulates with mild salt and water abnormalities due to its longer half-life in the circulation.…”

Section: Discussionmentioning

confidence: 94%

Increased Release of the N-Terminal and C-Terminal Portions of the Atrial Natriuretic Factor Prohormone during Immersion-Induced Central Hypervolemia in Cirrhotic Humans

Vesely

Preston²,

Winters

et al. 1991

Am J Nephrol

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The role of peptides from the N-terminus and C-terminus of the 126 amino acid (a.a.) atrial natriuretic factors (ANF) prohormone in modulating renal sodium and water handling in cirrhotic patients has not been defined. Eight cirrhotic individuals were evaluated; their mean basal circulating concentration of the C-terminus (a.a. 99–126; i.e., ANF) was 25 ± 2 fmol/ml, not different from the 22 ± 1 fmol/ml value found in 54 normal volunteers. On the other hand, the basal circulating concentrations of the whole N-terminus (a.a. 1–98) and the midportion of the N-terminus (namely a.a. 31–67; pro ANF 31–67) of the ANF prohormone in these cirrhotic subjects of 704 ± 52 and 654 ± 83 fmol/ml were significantly elevated (p < 0.05; ANOVA) in comparison to control values (531 ± 25, 317 ± 22 fmol/ml, respectively). Following equilibration on a 10 mmol/day sodium diet, the responsiveness of the N-terminus and C-terminus of ANF prohormone to 3 h of water immersion, which induces marked acute central volume expansion, was evaluated in these 8 seated cirrhotic patients. There was a prompt increase in the circulating concentrations of immunoreactive (ir) pro ANF 1–98 (whole N-terminus), ir pro ANF 31–67, and ir ANF (C-terminus) within 15 min of immersion (p < 0.05; ANOVA) compared to their preimmersion values. The response of circulating ir pro ANF 1–98, pro ANF 31–67, and ANF concentrations in these 8 cirrhotic subjects to immersion was significantly greater (p < 0.05; ANOVA) than that of 7 healthy volunteers undergoing an identical 3-hour immersion study. With cessation of immersion, the C-terminus decreased within 30 min to a concentration not significantly different from preimmersion values, whereas the N-terminus and pro ANF 31–67 remained significantly elevated after 1 h.

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Change in Plasma Immunoreactive N-Terminus, C-Terminus, and 4,000-Dalton Midportion of Atrial Natriuretic Factor Prohormone with Hemodialysis

Cited by 29 publications

References 21 publications

Natriuretic Peptides’ Role in Determining the Chemotherapy-Induced Nephrotoxicity and Their Value in Follow-Up

Natriuretic Peptides’ Role in Determining the Chemotherapy-Induced Nephrotoxicity and Their Value in Follow-Up

Vessel Dilator Enhances Sodium and Water Excretion and Has Beneficial Hemodynamic Effects in Persons With Congestive Heart Failure

Increased Release of the N-Terminal and C-Terminal Portions of the Atrial Natriuretic Factor Prohormone during Immersion-Induced Central Hypervolemia in Cirrhotic Humans

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